Yeast as a model system to study RecQ helicase function

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Yeast as a model system to study RecQ helicase function. / Ashton, Thomas M; Hickson, Ian David.

In: DNA Repair, Vol. 9, No. 3, 2010, p. 303-14.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ashton, TM & Hickson, ID 2010, 'Yeast as a model system to study RecQ helicase function', DNA Repair, vol. 9, no. 3, pp. 303-14. https://doi.org/10.1016/j.dnarep.2009.12.007

APA

Ashton, T. M., & Hickson, I. D. (2010). Yeast as a model system to study RecQ helicase function. DNA Repair, 9(3), 303-14. https://doi.org/10.1016/j.dnarep.2009.12.007

Vancouver

Ashton TM, Hickson ID. Yeast as a model system to study RecQ helicase function. DNA Repair. 2010;9(3):303-14. https://doi.org/10.1016/j.dnarep.2009.12.007

Author

Ashton, Thomas M ; Hickson, Ian David. / Yeast as a model system to study RecQ helicase function. In: DNA Repair. 2010 ; Vol. 9, No. 3. pp. 303-14.

Bibtex

@article{e9cc5a70958f11df928f000ea68e967b,
title = "Yeast as a model system to study RecQ helicase function",
abstract = "Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1(+), respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.",
author = "Ashton, {Thomas M} and Hickson, {Ian David}",
note = "Keywords: Animals; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA, Fungal; Humans; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins",
year = "2010",
doi = "10.1016/j.dnarep.2009.12.007",
language = "English",
volume = "9",
pages = "303--14",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Yeast as a model system to study RecQ helicase function

AU - Ashton, Thomas M

AU - Hickson, Ian David

N1 - Keywords: Animals; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; DNA, Fungal; Humans; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins

PY - 2010

Y1 - 2010

N2 - Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1(+), respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.

AB - Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1(+), respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.

U2 - 10.1016/j.dnarep.2009.12.007

DO - 10.1016/j.dnarep.2009.12.007

M3 - Review

C2 - 20071248

VL - 9

SP - 303

EP - 314

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 3

ER -

ID: 20971244