Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals
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Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. / da Cunha-Bang, Sophie; Stenbæk, Dea Siggaard; Holst, Klaus; Licht, Cecilie Löe; Jensen, Peter Steen; Frokjaer, Vibe Gedsø; Mortensen, Erik Lykke; Knudsen, Gitte Moos.
In: Psychiatry Research, Vol. 212, No. 2, 2013, p. 125-131.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals
AU - da Cunha-Bang, Sophie
AU - Stenbæk, Dea Siggaard
AU - Holst, Klaus
AU - Licht, Cecilie Löe
AU - Jensen, Peter Steen
AU - Frokjaer, Vibe Gedsø
AU - Mortensen, Erik Lykke
AU - Knudsen, Gitte Moos
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013
Y1 - 2013
N2 - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [(18)F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.
AB - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [(18)F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.
KW - Aggression
KW - Impulsivity
KW - Positron Emission Tomography (PET)
KW - Serotonin
U2 - 10.1016/j.pscychresns.2012.09.007
DO - 10.1016/j.pscychresns.2012.09.007
M3 - Journal article
C2 - 23137806
VL - 212
SP - 125
EP - 131
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 2
ER -
ID: 118042826