The role of RecQ helicases in non-homologous end-joining

Research output: Contribution to journal › Review › Research › peer-review

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The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Keijzers, G, Maynard, S, Shamanna, RA, Rasmussen, LJ, Croteau, DL & Bohr, VA 2014, 'The role of RecQ helicases in non-homologous end-joining', Critical Reviews in Biochemistry and Molecular Biology, vol. 49, no. 6, pp. 463-472. https://doi.org/10.3109/10409238.2014.942450

APA

Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, L. J., Croteau, D. L., & Bohr, V. A. (2014). The role of RecQ helicases in non-homologous end-joining. Critical Reviews in Biochemistry and Molecular Biology, 49(6), 463-472. https://doi.org/10.3109/10409238.2014.942450

Vancouver

Keijzers G, Maynard S, Shamanna RA, Rasmussen LJ, Croteau DL, Bohr VA. The role of RecQ helicases in non-homologous end-joining. Critical Reviews in Biochemistry and Molecular Biology. 2014 Nov;49(6):463-472. https://doi.org/10.3109/10409238.2014.942450

Author

Keijzers, Guido ; Maynard, Scott ; Shamanna, Raghavendra A ; Rasmussen, Lene Juel ; Croteau, Deborah L ; Bohr, Vilhelm A. / The role of RecQ helicases in non-homologous end-joining. In: Critical Reviews in Biochemistry and Molecular Biology. 2014 ; Vol. 49, No. 6. pp. 463-472.

Bibtex

@article{ab9448657cba41b6b7e6f33ab89a37e4,
title = "The role of RecQ helicases in non-homologous end-joining",
abstract = "Abstract DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.",
author = "Guido Keijzers and Scott Maynard and Shamanna, {Raghavendra A} and Rasmussen, {Lene Juel} and Croteau, {Deborah L} and Bohr, {Vilhelm A}",
year = "2014",
month = nov,
doi = "10.3109/10409238.2014.942450",
language = "English",
volume = "49",
pages = "463--472",
journal = "Critical Reviews in Biochemistry and Molecular Biology",
issn = "1040-9238",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - The role of RecQ helicases in non-homologous end-joining

AU - Keijzers, Guido

AU - Maynard, Scott

AU - Shamanna, Raghavendra A

AU - Rasmussen, Lene Juel

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

PY - 2014/11

Y1 - 2014/11

N2 - Abstract DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

AB - Abstract DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

U2 - 10.3109/10409238.2014.942450

DO - 10.3109/10409238.2014.942450

M3 - Review

C2 - 25048400

VL - 49

SP - 463

EP - 472

JO - Critical Reviews in Biochemistry and Molecular Biology

JF - Critical Reviews in Biochemistry and Molecular Biology

SN - 1040-9238

IS - 6

ER -

ID: 119407677