The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

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The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells. / Wu, Wei; Hickson, Ian David; Liu, Ying.

In: Genome Instability & Disease, Vol. 1, No. 3, 2020, p. 114–128.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Wu, W, Hickson, ID & Liu, Y 2020, 'The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells', Genome Instability & Disease, vol. 1, no. 3, pp. 114–128. https://doi.org/10.1007/s42764-020-00012-z

APA

Wu, W., Hickson, I. D., & Liu, Y. (2020). The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells. Genome Instability & Disease, 1(3), 114–128. https://doi.org/10.1007/s42764-020-00012-z

Vancouver

Wu W, Hickson ID, Liu Y. The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells. Genome Instability & Disease. 2020;1(3):114–128. https://doi.org/10.1007/s42764-020-00012-z

Author

Wu, Wei ; Hickson, Ian David ; Liu, Ying. / The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells. In: Genome Instability & Disease. 2020 ; Vol. 1, No. 3. pp. 114–128.

Bibtex

@article{8d21795002dc472491170362082ea6ab,
title = "The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells",
abstract = "DNA fulfills two critical roles in a cell by being the template for both DNA replication and RNA transcription. During evolution, eukaryotic cells have adopted multiple strategies to coordinate these two processes to prevent or minimize conflicts that might arise between them. Here, we review the strategies employed by cells to simultaneously accommodate the machineries carrying out DNA replication and transcription, and the mechanisms that are brought into play for resolving conflicts when they do arise. We focus on a group of the so-called {\textquoteleft}difficult-to-replicate{\textquoteright} loci in the human genome, which include chromosome fragile sites, the ribosomal DNA, and telomeres. A failure to resolve conflicts arising between replication and transcription can lead to genome instability, as well as to the initiation of cancer and other age-associated diseases. Understanding the mechanisms required for the resolution of these conflicts could, therefore, open up new therapeutic avenues.",
author = "Wei Wu and Hickson, {Ian David} and Ying Liu",
year = "2020",
doi = "10.1007/s42764-020-00012-z",
language = "English",
volume = "1",
pages = "114–128",
journal = "Genome Instability & Disease",
issn = "2524-7662",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

AU - Wu, Wei

AU - Hickson, Ian David

AU - Liu, Ying

PY - 2020

Y1 - 2020

N2 - DNA fulfills two critical roles in a cell by being the template for both DNA replication and RNA transcription. During evolution, eukaryotic cells have adopted multiple strategies to coordinate these two processes to prevent or minimize conflicts that might arise between them. Here, we review the strategies employed by cells to simultaneously accommodate the machineries carrying out DNA replication and transcription, and the mechanisms that are brought into play for resolving conflicts when they do arise. We focus on a group of the so-called ‘difficult-to-replicate’ loci in the human genome, which include chromosome fragile sites, the ribosomal DNA, and telomeres. A failure to resolve conflicts arising between replication and transcription can lead to genome instability, as well as to the initiation of cancer and other age-associated diseases. Understanding the mechanisms required for the resolution of these conflicts could, therefore, open up new therapeutic avenues.

AB - DNA fulfills two critical roles in a cell by being the template for both DNA replication and RNA transcription. During evolution, eukaryotic cells have adopted multiple strategies to coordinate these two processes to prevent or minimize conflicts that might arise between them. Here, we review the strategies employed by cells to simultaneously accommodate the machineries carrying out DNA replication and transcription, and the mechanisms that are brought into play for resolving conflicts when they do arise. We focus on a group of the so-called ‘difficult-to-replicate’ loci in the human genome, which include chromosome fragile sites, the ribosomal DNA, and telomeres. A failure to resolve conflicts arising between replication and transcription can lead to genome instability, as well as to the initiation of cancer and other age-associated diseases. Understanding the mechanisms required for the resolution of these conflicts could, therefore, open up new therapeutic avenues.

U2 - 10.1007/s42764-020-00012-z

DO - 10.1007/s42764-020-00012-z

M3 - Review

VL - 1

SP - 114

EP - 128

JO - Genome Instability & Disease

JF - Genome Instability & Disease

SN - 2524-7662

IS - 3

ER -

ID: 241416738