The origins and processing of ultra fine anaphase DNA bridges
Research output: Contribution to journal › Review › Research › peer-review
Standard
The origins and processing of ultra fine anaphase DNA bridges. / Liu, Ying; Nielsen, Christian Friberg; Yao, Qi; Hickson, Ian D.
In: Current Opinion in Genetics & Development, Vol. 26C, 30.04.2014, p. 1-5.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The origins and processing of ultra fine anaphase DNA bridges
AU - Liu, Ying
AU - Nielsen, Christian Friberg
AU - Yao, Qi
AU - Hickson, Ian D
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/4/30
Y1 - 2014/4/30
N2 - Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.
AB - Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using DAPI). Their existence can currently only be revealed by immuno-fluorescent staining for proteins that bind to them, including PICH and BLM. UFBs become visible in the anaphase of mitosis, and can persist into telophase in rare cases. There are at least three different types of UFBs that can be distinguished according to the chromosomal loci from which they originate. However, it remains largely unknown how these UFBs are generated or resolved in the cell. In this article, we will review our current understanding of different types of UFBs and the potential functional role of the proteins that have been shown to be associated with them.
U2 - 10.1016/j.gde.2014.03.003
DO - 10.1016/j.gde.2014.03.003
M3 - Review
C2 - 24795279
VL - 26C
SP - 1
EP - 5
JO - Current Opinion in Genetics & Development
JF - Current Opinion in Genetics & Development
SN - 0959-437X
ER -
ID: 112891517