The Detection and Analysis of Chromosome Fragile Sites

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

The Detection and Analysis of Chromosome Fragile Sites. / Bjerregaard, Victoria A; Özer, Özgün; Hickson, Ian D; Liu, Ying.

Genome Instability: Methods and Protocols. Vol. 1672 Springer, 2018. p. 471-482 (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Bjerregaard, VA, Özer, Ö, Hickson, ID & Liu, Y 2018, The Detection and Analysis of Chromosome Fragile Sites. in Genome Instability: Methods and Protocols. vol. 1672, Springer, Methods in molecular biology (Clifton, N.J.), pp. 471-482. https://doi.org/10.1007/978-1-4939-7306-4_31

APA

Bjerregaard, V. A., Özer, Ö., Hickson, I. D., & Liu, Y. (2018). The Detection and Analysis of Chromosome Fragile Sites. In Genome Instability: Methods and Protocols (Vol. 1672, pp. 471-482). Springer. Methods in molecular biology (Clifton, N.J.) https://doi.org/10.1007/978-1-4939-7306-4_31

Vancouver

Bjerregaard VA, Özer Ö, Hickson ID, Liu Y. The Detection and Analysis of Chromosome Fragile Sites. In Genome Instability: Methods and Protocols. Vol. 1672. Springer. 2018. p. 471-482. (Methods in molecular biology (Clifton, N.J.)). https://doi.org/10.1007/978-1-4939-7306-4_31

Author

Bjerregaard, Victoria A ; Özer, Özgün ; Hickson, Ian D ; Liu, Ying. / The Detection and Analysis of Chromosome Fragile Sites. Genome Instability: Methods and Protocols. Vol. 1672 Springer, 2018. pp. 471-482 (Methods in molecular biology (Clifton, N.J.)).

Bibtex

@inbook{59a36d3a140643828b3fdb8ee0e494e2,
title = "The Detection and Analysis of Chromosome Fragile Sites",
abstract = "A fragile site is a chromosomal locus that is prone to form a gap or constriction visible within a condensed metaphase chromosome, particularly following exposure of cells to DNA replication stress. Based on their frequency, fragile sites are classified as either common (CFSs; present in all individuals) or rare (RFSs; present in only a few individuals). Interest in fragile sites has remained high since their discovery in 1965, because of their association with human disease. CFSs are recognized as drivers of oncogene activation and genome instability in cancer cells, while some RFSs are associated with neurodegenerative diseases. This review summaries our current understanding of the nature and causes of fragile site {"}expression{"}, including the recently characterized phenomenon of telomere fragility. In particular, we focus on a description of the methodologies and technologies for detection and analysis of chromosome fragile sites.",
author = "Bjerregaard, {Victoria A} and {\"O}zg{\"u}n {\"O}zer and Hickson, {Ian D} and Ying Liu",
year = "2018",
doi = "10.1007/978-1-4939-7306-4_31",
language = "English",
isbn = "978-1-4939-7305-7",
volume = "1672",
series = "Methods in molecular biology (Clifton, N.J.)",
publisher = "Springer",
pages = "471--482",
booktitle = "Genome Instability",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - The Detection and Analysis of Chromosome Fragile Sites

AU - Bjerregaard, Victoria A

AU - Özer, Özgün

AU - Hickson, Ian D

AU - Liu, Ying

PY - 2018

Y1 - 2018

N2 - A fragile site is a chromosomal locus that is prone to form a gap or constriction visible within a condensed metaphase chromosome, particularly following exposure of cells to DNA replication stress. Based on their frequency, fragile sites are classified as either common (CFSs; present in all individuals) or rare (RFSs; present in only a few individuals). Interest in fragile sites has remained high since their discovery in 1965, because of their association with human disease. CFSs are recognized as drivers of oncogene activation and genome instability in cancer cells, while some RFSs are associated with neurodegenerative diseases. This review summaries our current understanding of the nature and causes of fragile site "expression", including the recently characterized phenomenon of telomere fragility. In particular, we focus on a description of the methodologies and technologies for detection and analysis of chromosome fragile sites.

AB - A fragile site is a chromosomal locus that is prone to form a gap or constriction visible within a condensed metaphase chromosome, particularly following exposure of cells to DNA replication stress. Based on their frequency, fragile sites are classified as either common (CFSs; present in all individuals) or rare (RFSs; present in only a few individuals). Interest in fragile sites has remained high since their discovery in 1965, because of their association with human disease. CFSs are recognized as drivers of oncogene activation and genome instability in cancer cells, while some RFSs are associated with neurodegenerative diseases. This review summaries our current understanding of the nature and causes of fragile site "expression", including the recently characterized phenomenon of telomere fragility. In particular, we focus on a description of the methodologies and technologies for detection and analysis of chromosome fragile sites.

U2 - 10.1007/978-1-4939-7306-4_31

DO - 10.1007/978-1-4939-7306-4_31

M3 - Book chapter

C2 - 29043642

SN - 978-1-4939-7305-7

VL - 1672

T3 - Methods in molecular biology (Clifton, N.J.)

SP - 471

EP - 482

BT - Genome Instability

PB - Springer

ER -

ID: 190850028