Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. / Xing, Meichun; Zhang, Fengjiao; Liao, Hongwei; Chen, Sisi; Che, Luanqing; Wang, Xiaohui; Bao, Zhengqiang; Ji, Fang; Chen, Gaoying; Zhang, Huihui; Li, Wen; Chen, Zhihua; Liu, Ying; Hickson, Ian D.; Shen, Huahao; Ying, Songmin.

In: Molecular Cell, Vol. 78, No. 4, 2020, p. 714-724.e5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xing, M, Zhang, F, Liao, H, Chen, S, Che, L, Wang, X, Bao, Z, Ji, F, Chen, G, Zhang, H, Li, W, Chen, Z, Liu, Y, Hickson, ID, Shen, H & Ying, S 2020, 'Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes', Molecular Cell, vol. 78, no. 4, pp. 714-724.e5. https://doi.org/10.1016/j.molcel.2020.04.005

APA

Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Y., Hickson, I. D., Shen, H., & Ying, S. (2020). Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. Molecular Cell, 78(4), 714-724.e5. https://doi.org/10.1016/j.molcel.2020.04.005

Vancouver

Xing M, Zhang F, Liao H, Chen S, Che L, Wang X et al. Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. Molecular Cell. 2020;78(4):714-724.e5. https://doi.org/10.1016/j.molcel.2020.04.005

Author

Xing, Meichun ; Zhang, Fengjiao ; Liao, Hongwei ; Chen, Sisi ; Che, Luanqing ; Wang, Xiaohui ; Bao, Zhengqiang ; Ji, Fang ; Chen, Gaoying ; Zhang, Huihui ; Li, Wen ; Chen, Zhihua ; Liu, Ying ; Hickson, Ian D. ; Shen, Huahao ; Ying, Songmin. / Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. In: Molecular Cell. 2020 ; Vol. 78, No. 4. pp. 714-724.e5.

Bibtex

@article{31549fe83a134430aa5f8fa57917023d,
title = "Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes",
abstract = "Nonrandom DNA segregation (NDS) is a mitotic event in which sister chromatids carrying the oldest DNA strands are inherited exclusively by one of the two daughter cells. Although this phenomenon has been observed across various organisms, the mechanism and physiological relevance of this event remain poorly defined. Here, we demonstrate that DNA replication stress can trigger NDS in human cells. This biased inheritance of old template DNA is associated with the asymmetric DNA damage response (DDR), which derives at least in part from telomeric DNA. Mechanistically, we reveal that the ATR/CHK1 signaling pathway plays an essential role in mediating NDS. We show that this biased segregation process leads to cell-cycle arrest and cell death in damaged daughter cells inheriting newly replicated DNA. These data therefore identify a key role for NDS in the maintenance of genomic integrity within cancer cell populations undergoing replication stress due to oncogene activation.",
keywords = "asymmetric DNA damage response, ATR/CHK1, biased inheritance, nonrandom DNA segregation, replication stress",
author = "Meichun Xing and Fengjiao Zhang and Hongwei Liao and Sisi Chen and Luanqing Che and Xiaohui Wang and Zhengqiang Bao and Fang Ji and Gaoying Chen and Huihui Zhang and Wen Li and Zhihua Chen and Ying Liu and Hickson, {Ian D.} and Huahao Shen and Songmin Ying",
year = "2020",
doi = "10.1016/j.molcel.2020.04.005",
language = "English",
volume = "78",
pages = "714--724.e5",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

AU - Xing, Meichun

AU - Zhang, Fengjiao

AU - Liao, Hongwei

AU - Chen, Sisi

AU - Che, Luanqing

AU - Wang, Xiaohui

AU - Bao, Zhengqiang

AU - Ji, Fang

AU - Chen, Gaoying

AU - Zhang, Huihui

AU - Li, Wen

AU - Chen, Zhihua

AU - Liu, Ying

AU - Hickson, Ian D.

AU - Shen, Huahao

AU - Ying, Songmin

PY - 2020

Y1 - 2020

N2 - Nonrandom DNA segregation (NDS) is a mitotic event in which sister chromatids carrying the oldest DNA strands are inherited exclusively by one of the two daughter cells. Although this phenomenon has been observed across various organisms, the mechanism and physiological relevance of this event remain poorly defined. Here, we demonstrate that DNA replication stress can trigger NDS in human cells. This biased inheritance of old template DNA is associated with the asymmetric DNA damage response (DDR), which derives at least in part from telomeric DNA. Mechanistically, we reveal that the ATR/CHK1 signaling pathway plays an essential role in mediating NDS. We show that this biased segregation process leads to cell-cycle arrest and cell death in damaged daughter cells inheriting newly replicated DNA. These data therefore identify a key role for NDS in the maintenance of genomic integrity within cancer cell populations undergoing replication stress due to oncogene activation.

AB - Nonrandom DNA segregation (NDS) is a mitotic event in which sister chromatids carrying the oldest DNA strands are inherited exclusively by one of the two daughter cells. Although this phenomenon has been observed across various organisms, the mechanism and physiological relevance of this event remain poorly defined. Here, we demonstrate that DNA replication stress can trigger NDS in human cells. This biased inheritance of old template DNA is associated with the asymmetric DNA damage response (DDR), which derives at least in part from telomeric DNA. Mechanistically, we reveal that the ATR/CHK1 signaling pathway plays an essential role in mediating NDS. We show that this biased segregation process leads to cell-cycle arrest and cell death in damaged daughter cells inheriting newly replicated DNA. These data therefore identify a key role for NDS in the maintenance of genomic integrity within cancer cell populations undergoing replication stress due to oncogene activation.

KW - asymmetric DNA damage response

KW - ATR/CHK1

KW - biased inheritance

KW - nonrandom DNA segregation

KW - replication stress

U2 - 10.1016/j.molcel.2020.04.005

DO - 10.1016/j.molcel.2020.04.005

M3 - Journal article

C2 - 32353258

AN - SCOPUS:85084637323

VL - 78

SP - 714-724.e5

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 4

ER -

ID: 242779905