New insights into the formation and resolution of ultra-fine anaphase bridges
Research output: Contribution to journal › Review › Research › peer-review
Standard
New insights into the formation and resolution of ultra-fine anaphase bridges. / Chan, Kok Lung; Hickson, Ian D.
In: Seminars in Cell and Developmental Biology, Vol. 22, No. 8, 10.2011, p. 906-12.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - New insights into the formation and resolution of ultra-fine anaphase bridges
AU - Chan, Kok Lung
AU - Hickson, Ian D
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011/10
Y1 - 2011/10
N2 - Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.
AB - Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.
KW - Anaphase
KW - Humans
KW - Models, Genetic
U2 - 10.1016/j.semcdb.2011.07.001
DO - 10.1016/j.semcdb.2011.07.001
M3 - Review
C2 - 21782962
VL - 22
SP - 906
EP - 912
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 8
ER -
ID: 38333236