How unfinished business from S-phase affects mitosis and beyond

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

How unfinished business from S-phase affects mitosis and beyond. / Mankouri, H.W.; Huttner, D.; Hickson, I.D.

In: EMBO Journal, Vol. 32, No. 20, 16.10.2013, p. 2661-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mankouri, HW, Huttner, D & Hickson, ID 2013, 'How unfinished business from S-phase affects mitosis and beyond', EMBO Journal, vol. 32, no. 20, pp. 2661-71. https://doi.org/10.1038/emboj.2013.211

APA

Mankouri, H. W., Huttner, D., & Hickson, I. D. (2013). How unfinished business from S-phase affects mitosis and beyond. EMBO Journal, 32(20), 2661-71. https://doi.org/10.1038/emboj.2013.211

Vancouver

Mankouri HW, Huttner D, Hickson ID. How unfinished business from S-phase affects mitosis and beyond. EMBO Journal. 2013 Oct 16;32(20):2661-71. https://doi.org/10.1038/emboj.2013.211

Author

Mankouri, H.W. ; Huttner, D. ; Hickson, I.D. / How unfinished business from S-phase affects mitosis and beyond. In: EMBO Journal. 2013 ; Vol. 32, No. 20. pp. 2661-71.

Bibtex

@article{671c96ec6c7c411eaab5a5d460e9f097,
title = "How unfinished business from S-phase affects mitosis and beyond",
abstract = "The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely replicated, or unresolved, chromosomes from S-phase can persist into mitosis, where they present a potential threat to the faithful segregation of sister chromatids. In this review, we provide an overview of the different classes of loci where this 'unfinished S-phase business' can lead to a variety of cytogenetically distinct DNA structures throughout the various steps of mitosis. Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability.",
keywords = "Animals, Cell Cycle Proteins, Chromatids, Chromosomes, DNA Replication, Genomic Instability, Humans, Mitosis, Models, Biological, S Phase",
author = "H.W. Mankouri and D. Huttner and I.D. Hickson",
year = "2013",
month = oct,
day = "16",
doi = "10.1038/emboj.2013.211",
language = "English",
volume = "32",
pages = "2661--71",
journal = "E M B O Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "20",

}

RIS

TY - JOUR

T1 - How unfinished business from S-phase affects mitosis and beyond

AU - Mankouri, H.W.

AU - Huttner, D.

AU - Hickson, I.D.

PY - 2013/10/16

Y1 - 2013/10/16

N2 - The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely replicated, or unresolved, chromosomes from S-phase can persist into mitosis, where they present a potential threat to the faithful segregation of sister chromatids. In this review, we provide an overview of the different classes of loci where this 'unfinished S-phase business' can lead to a variety of cytogenetically distinct DNA structures throughout the various steps of mitosis. Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability.

AB - The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely replicated, or unresolved, chromosomes from S-phase can persist into mitosis, where they present a potential threat to the faithful segregation of sister chromatids. In this review, we provide an overview of the different classes of loci where this 'unfinished S-phase business' can lead to a variety of cytogenetically distinct DNA structures throughout the various steps of mitosis. Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability.

KW - Animals

KW - Cell Cycle Proteins

KW - Chromatids

KW - Chromosomes

KW - DNA Replication

KW - Genomic Instability

KW - Humans

KW - Mitosis

KW - Models, Biological

KW - S Phase

UR - http://www.scopus.com/inward/record.url?scp=84885843614&partnerID=8YFLogxK

U2 - 10.1038/emboj.2013.211

DO - 10.1038/emboj.2013.211

M3 - Journal article

C2 - 24065128

AN - SCOPUS:84885843614

VL - 32

SP - 2661

EP - 2671

JO - E M B O Journal

JF - E M B O Journal

SN - 0261-4189

IS - 20

ER -

ID: 88655564