Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis

Research output: Contribution to journal › Review › Research › peer-review

Standard

Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis. / Ying, Songmin; Hickson, Ian D.

In: U H O D, Vol. 93, No. 4, 01.04.2011, p. 440-5.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ying, S & Hickson, ID 2011, 'Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis', U H O D, vol. 93, no. 4, pp. 440-5. https://doi.org/10.1007/s12185-011-0818-7

APA

Ying, S., & Hickson, I. D. (2011). Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis. U H O D, 93(4), 440-5. https://doi.org/10.1007/s12185-011-0818-7

Vancouver

Ying S, Hickson ID. Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis. U H O D. 2011 Apr 1;93(4):440-5. https://doi.org/10.1007/s12185-011-0818-7

Author

Ying, Songmin ; Hickson, Ian D. / Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis. In: U H O D. 2011 ; Vol. 93, No. 4. pp. 440-5.

Bibtex

@article{8ed71aa3574240189941c35a0dd42955,
title = "Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis",
abstract = "The maintenance of genome stability is critical for the suppression of cancer and premature ageing. The maintenance of the human genome requires hundreds of proteins involved in DNA repair, DNA replication, chromosome segregation and cell cycle checkpoint responses. A number of genetic disorders exist in man where a breakdown in genome maintenance is associated with cancer predisposition. Amongst these are Bloom's syndrome (BS) and Fanconi anaemia (FA). The BS and FA gene products co-operate in the repair of damaged DNA. In this review, we focus on interactions between BS and FA proteins that specifically occur during chromosome segregation in mitosis. The BS protein, BLM, was shown recently to define a novel class of anaphase DNA bridge structures that, in some cases, also contain FA proteins. We will discuss the possible source of these bridges and the role that FA proteins and BLM might play in their removal.",
author = "Songmin Ying and Hickson, {Ian D}",
year = "2011",
month = apr,
day = "1",
doi = "10.1007/s12185-011-0818-7",
language = "English",
volume = "93",
pages = "440--5",
journal = "UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi",
issn = "1306-133X",
publisher = "Akademi Doktorlar Yayinevi",
number = "4",

}

RIS

TY - JOUR

T1 - Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis

AU - Ying, Songmin

AU - Hickson, Ian D

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The maintenance of genome stability is critical for the suppression of cancer and premature ageing. The maintenance of the human genome requires hundreds of proteins involved in DNA repair, DNA replication, chromosome segregation and cell cycle checkpoint responses. A number of genetic disorders exist in man where a breakdown in genome maintenance is associated with cancer predisposition. Amongst these are Bloom's syndrome (BS) and Fanconi anaemia (FA). The BS and FA gene products co-operate in the repair of damaged DNA. In this review, we focus on interactions between BS and FA proteins that specifically occur during chromosome segregation in mitosis. The BS protein, BLM, was shown recently to define a novel class of anaphase DNA bridge structures that, in some cases, also contain FA proteins. We will discuss the possible source of these bridges and the role that FA proteins and BLM might play in their removal.

AB - The maintenance of genome stability is critical for the suppression of cancer and premature ageing. The maintenance of the human genome requires hundreds of proteins involved in DNA repair, DNA replication, chromosome segregation and cell cycle checkpoint responses. A number of genetic disorders exist in man where a breakdown in genome maintenance is associated with cancer predisposition. Amongst these are Bloom's syndrome (BS) and Fanconi anaemia (FA). The BS and FA gene products co-operate in the repair of damaged DNA. In this review, we focus on interactions between BS and FA proteins that specifically occur during chromosome segregation in mitosis. The BS protein, BLM, was shown recently to define a novel class of anaphase DNA bridge structures that, in some cases, also contain FA proteins. We will discuss the possible source of these bridges and the role that FA proteins and BLM might play in their removal.

U2 - 10.1007/s12185-011-0818-7

DO - 10.1007/s12185-011-0818-7

M3 - Review

C2 - 21472397

VL - 93

SP - 440

EP - 445

JO - UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi

JF - UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi

SN - 1306-133X

IS - 4

ER -

ID: 33489732