Exonuclease 1 and its versatile roles in DNA repair
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Exonuclease 1 and its versatile roles in DNA repair. / Keijzers, Guido; Liu, Dekang; Rasmussen, Lene Juel.
In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 51, No. 6, 05.08.2016, p. 440–451.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Exonuclease 1 and its versatile roles in DNA repair
AU - Keijzers, Guido
AU - Liu, Dekang
AU - Rasmussen, Lene Juel
PY - 2016/8/5
Y1 - 2016/8/5
N2 - Exonuclease 1 (EXO1) is a multifunctional 5' → 3' exonuclease and a DNA structure-specific DNA endonuclease. EXO1 plays roles in DNA replication, DNA mismatch repair (MMR) and DNA double-stranded break repair (DSBR) in lower and higher eukaryotes and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining in higher eukaryotes. In human cells, EXO1 is also thought to play a role in telomere maintenance. Mutations in the human EXO1 gene correlate with increased susceptibility to some cancers. This review summarizes recent studies on the enzymatic functions and biological roles of EXO1, its possible protective role against cancer and aging, and regulation of EXO1 by posttranslational modification.
AB - Exonuclease 1 (EXO1) is a multifunctional 5' → 3' exonuclease and a DNA structure-specific DNA endonuclease. EXO1 plays roles in DNA replication, DNA mismatch repair (MMR) and DNA double-stranded break repair (DSBR) in lower and higher eukaryotes and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining in higher eukaryotes. In human cells, EXO1 is also thought to play a role in telomere maintenance. Mutations in the human EXO1 gene correlate with increased susceptibility to some cancers. This review summarizes recent studies on the enzymatic functions and biological roles of EXO1, its possible protective role against cancer and aging, and regulation of EXO1 by posttranslational modification.
U2 - 10.1080/10409238.2016.1215407
DO - 10.1080/10409238.2016.1215407
M3 - Review
C2 - 27494243
VL - 51
SP - 440
EP - 451
JO - Critical Reviews in Biochemistry and Molecular Biology
JF - Critical Reviews in Biochemistry and Molecular Biology
SN - 1040-9238
IS - 6
ER -
ID: 169440757