Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
Research output: Contribution to journal › Journal article › Research › peer-review
Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In the current study, we aimed to develop small molecule inhibitors of APE1 for cancer therapy.
| Original language | English |
|---|---|
| Journal | British Journal of Cancer Management |
| Volume | 104 |
| Issue number | 4 |
| Pages (from-to) | 653-63 |
| Number of pages | 11 |
| ISSN | 1744-3865 |
| DOIs | |
| Publication status | Published - 15 Feb 2011 |
- Brain Neoplasms, Cell Line, Tumor, DNA-(Apurinic or Apyrimidinic Site) Lyase, Drug Discovery, Drug Evaluation, Preclinical, Enzyme Inhibitors, Glioma, Hela Cells, High-Throughput Screening Assays, Humans, Inhibitory Concentration 50, Melanoma, Models, Biological, Models, Molecular, Structure-Activity Relationship
Research areas
ID: 33489785