Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
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Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.
In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
AU - Cheng, Chang
AU - Edin, Nina F Jeppesen
AU - Lauritzen, Knut H
AU - Aspmodal, Ida
AU - Christoffersen, Stine
AU - Jian, Liu
AU - Rasmussen, Lene Juel
AU - Pettersen, Erik O
AU - Xiaoqun, Gao
AU - Bergersen, Linda H
PY - 2012/6
Y1 - 2012/6
N2 - Tumour cells are characterized by aerobic glycolysis, which provides biomass for tumour proliferation and leads to extracellular acidification through efflux of lactate via monocarboxylate transporters (MCTs). Deficient and spasm-prone tumour vasculature causes variable hypoxia, which favours tumour cell survival and metastases. Brain metastases frequently occur in patients with advanced breast cancer.Effective treatment strategies are therefore needed against brain metastasis from breast carcinoma.
AB - Tumour cells are characterized by aerobic glycolysis, which provides biomass for tumour proliferation and leads to extracellular acidification through efflux of lactate via monocarboxylate transporters (MCTs). Deficient and spasm-prone tumour vasculature causes variable hypoxia, which favours tumour cell survival and metastases. Brain metastases frequently occur in patients with advanced breast cancer.Effective treatment strategies are therefore needed against brain metastasis from breast carcinoma.
U2 - 10.1007/s13402-012-0081-9
DO - 10.1007/s13402-012-0081-9
M3 - Journal article
C2 - 22700320
VL - 35
SP - 217
EP - 227
JO - Cellular oncology (Dordrecht)
JF - Cellular oncology (Dordrecht)
SN - 2211-3428
IS - 3
ER -
ID: 40802359