Ian David Hickson
Professor
- 2024
- Published
PICH deficiency limits the progression of MYC-induced B-cell lymphoma
Castejón-Griñán, M., Albers, E., Simón-Carrasco, L., Aguilera, P., Sbroggio, M., Pladevall Morera, David, Ingham, Andreas, Lim, Ernest Wee Kiat, Guillen-Benitez, A., Pietrini, E., Lisby, Michael, Hickson, Ian David & Lopez-Contreras, Andres, 2024, In: Blood Cancer Journal. 14, 1, 15 p., 16.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Completing genome replication outside of S phase
Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2023, In: Molecular Cell. 83, 20, p. 3596-3607 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
Danino, Y. M., Molitor, L., Rosenbaum-Cohen, T., Kaiser, Sebastian, Cohen, Y., Porat, Z., Marmor-Kollet, H., Katina, C., Savidor, A., Rotkopf, R., Ben-Isaac, E., Golani, O., Levin, Y., Monchaud, D., Hickson, Ian David & Hornstein, E., 2023, In: Nucleic Acids Research. 51, 17, p. 9369-9384 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclin E overexpression in the Drosophila accessory gland induces tissue dysplasia
Molano-Fernández, M., Hickson, Ian David & Herranz, Hector, 2023, In: Frontiers in Cell and Developmental Biology. 10, 992253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viscoelastic Capillary Flow Cytometry
Serhatlioglu, M., Jensen, E. A., Niora, M., Hansen, A. T., Nielsen, Christian Friberg, Jansman, M. M. T., Hosta-rigau, L., Dziegiel, Morten Hanefeld, Berg-sørensen, K., Hickson, Ian David & Kristensen, A., 2023, In: Advanced NanoBiomed Research. 3, 2, 2200137.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
Bakx, J. A. M., Biebricher, A. S., King, G. A., Christodoulis, P., Sarlós, K., Bizard, A. H., Hickson, Ian David, Wuite, G. J. L. & Peterman, E. J. G., 2022, In: Nature Communications. 13, 1, 584.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RAD51 protects human cells from transcription-replication conflicts
Bhowmick, Rahul, Lerdrup, Mads, Gadi, Sampath Amitash, Rossetti, G. G., Singh, Manika Indrajit, Liu, Ying, Halazonetis, T. D. & Hickson, Ian David, 2022, In: Molecular Cell. 82, 18, p. 3366-3381.e9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response
Geng, X., Zhang, C., Li, M., Wang, J., Ji, F., Feng, H., Xing, M., Li, F., Zhang, L., Li, W., Chen, Z., Hickson, Ian David, Shen, H. & Ying, S., 2022, In: Advanced Science. 9, 7, 2103837.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nonlinear mechanics of human mitotic chromosomes
Meijering, A. E. C., Sarlós, K., Nielsen, Christian Friberg, Witt, H., Harju, J., Kerklingh, E., Haasnoot, G. H., Bizard, A. H., Heller, I., Broedersz, C. P., Liu, Ying, Peterman, E. J. G., Hickson, Ian David & Wuite, G. J. L., 2022, In: Nature. p. 545–550Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a fiber-based microfluidic flow cytometry platform using viscoelastic fluids for polydisperse particle suspensions
Serhatlioglu, M., Jensen, E. A., Niora, M., Hansen, A. T., Nielsen, Christian Friberg, Theresia Jansman, M. M., Hosta-Rigau, L., Dziegiel, Morten Hanefeld, Berg-Sørensen, K., Hickson, Ian David & Kristensen, A., 2022, In: Proceedings of SPIE - The International Society for Optical Engineering. 12198, 9 p., 1219802.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
PICH acts as a force-dependent nucleosome remodeler
Spakman, D., Clement, T. V. M., Biebricher, A. S., King, G. A., Singh, Manika Indrajit, Hickson, Ian David, Peterman, E. J. G. & Wuite, G. J. L., 2022, In: Nature Communications. 13, 7277.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation
Vajen, B., Bhowmick, Rahul, Greiwe, L., Schäffer, V., Eilers, M., Reinkens, T., Stalke, A., Schmidt, G., Fiedler, J., Thum, T., Deluca, D. S., Hickson, Ian David, Schlegelberger, B., Illig, T. & Skawran, B., 2022, In: International Journal of Molecular Sciences. 23, 9, 5131.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
The many lives of type IA topoisomerases
Bizard, A. H. & Hickson, Ian David, 2020, In: Journal of Biological Chemistry. 295, 20, p. 7138-7153 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Bagge, Keerthana Stine Viswalingam, Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumour predisposition and cancer syndromes as models to study gene–environment interactions
Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, , 2020, In: Nature Reviews Cancer. 20, p. 533–549Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Simvastatin improves mitochondrial respiration in peripheral blood cells
Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells
Garribba, L., Bjerregaard, Victoria Alexandra, Gonçalves Dinis, M. M., Özer, Ö., Wu, Wei, Sakellariou, D., Pena-Diaz, J., Hickson, Ian David & Liu, Ying, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 28, p. 16527-16536 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing
Macheret, M., Bhowmick, Rahul, Sobkowiak, K., Padayachy, L., Mailler, J., Hickson, Ian David & Halazonetis, T. D., 2020, In: Cell Research. 30, p. 997–1008Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
Venegas, A. B., Natsume, T., Kanemaki, M. & Hickson, Ian David, 2020, In: Cell Reports. 31, 3, 20 p., 107533.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome
Wu, Wei, Bhowmick, Rahul, Vogel, Ivan, Özer, Ö., Ghisays, F., Thakur, R. S., Sanchez de Leon, E., Richter, P. H., Ren, L., Petrini, J. H., Hickson, Ian David & Liu, Ying, 2020, In: Nature Structural & Molecular Biology. 27, 5, p. 424-437 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells
Wu, Wei, Hickson, Ian David & Liu, Ying, 2020, In: Genome Instability & Disease. 1, 3, p. 114–128 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Ying, Hickson, Ian David, Shen, H. & Ying, S., 2020, In: Molecular Cell. 78, 4, p. 714-724.e5Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The RIF1-PP1 Axis Controls Abscission Timing in Human Cells
Bhowmick, Rahul, Thakur, R. S., Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In: Current Biology. 29, 7, p. 1232-1242.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICH and TOP3A cooperate to induce positive DNA supercoiling
Bizard, A. H., Allemand, J. F., Hassenkam, Tue, Paramasivam, M., Sarlós, K., Singh, Manika Indrajit & Hickson, Ian David, 2019, In: Nature Structural and Molecular Biology. 26, 4, p. 267-274 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Esc2 promotes telomere stability in response to DNA replication stress
Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
Sonneville, R., Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian David & Labib, K., 2019, In: eLife. 8, 19 p., e48686.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosome instability syndromes
Taylor, A. M. R., Rothblum-Oviatt, C., Ellis, N. A., Hickson, Ian David, Meyer, S., Crawford, T. O., Smogorzewska, A., Pietrucha, B., Weemaes, C. & Stewart, G. S., 2019, In: Nature Reviews. Disease Primers. 5, 20 p., 64.Research output: Contribution to journal › Review › Research › peer-review
- Published
DNA replication stress and its impact on chromosome segregation and tumorigenesis
Zhang, B. N., Bueno Venegas, A., Hickson, Ian David & Chu, W. K., 2019, In: Seminars in Cancer Biology. 55, p. 61-69Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
Albers, E., Sbroggiò, M., Pladevall Morera, David, Bizard, A. H., Avram, Alexandra Ioana, Gonzalez, P., Martin Gonzalez, Javier, Hickson, Ian David & Lopez-Contreras, Andres, 2018, In: Cell Reports. 24, 12, p. 3274-3284 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anaphase: a fortune-teller of genomic instability
Bizard, A. H. & Hickson, Ian David, Jun 2018, In: Current Opinion in Cell Biology. 52, p. 112-119 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Detection of Ultrafine Anaphase Bridges
Bizard, A. H., Nielsen, Christian Friberg & Hickson, Ian David, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 495-508 14 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Folate deficiency drives mitotic missegregation of the human FRAXA locus
Bjerregaard, Victoria Alexandra, Garribba, L., McMurray, C. T., Hickson, Ian David & Liu, Ying, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 13003-13008 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Detection and Analysis of Chromosome Fragile Sites
Bjerregaard, Victoria Alexandra, Özer, Ö., Hickson, Ian David & Liu, Ying, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 471-482 12 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci
Garribba, L., Wu, Wei, Özer, Ö., Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2018, Methods in Enzymology: Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Spies, M. & Malkova, A. (eds.). Elsevier, Vol. 601. p. 45-58 14 p. (Methods in Enzymology; No. 601).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation
Larsen, N. B., Hickson, Ian David & Mankouri, H. W., 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 295-309 15 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder
GOSgene, G., 2018, In: American Journal of Human Genetics. 103, 2, p. 221-231 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reconstitution of anaphase DNA bridge recognition and disjunction
Sarlós, K., Biebricher, A. S., Bizard, A. H., Bakx, J. A. M., Ferreté-Bonastre, A. G., Modesti, M., Paramasivam, M., Yao, Q., Peterman, E. J. G., Wuite, G. J. L. & Hickson, Ian David, 2018, In: Nature Structural and Molecular Biology. 25, 9, p. 868-876 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
Özer, Ö., Bhowmick, Rahul, Liu, Ying & Hickson, Ian David, 2018, In: OncoTarget. 9, 22, p. 15836-15846 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pathways for maintenance of telomeres and common fragile sites during DNA replication stress
Özer, Ö. & Hickson, Ian David, 2018, In: Open Biology. 8, 4, 11 p., 180018.Research output: Contribution to journal › Review › Research › peer-review
- 2017
- Published
The "enemies within": regions of the genome that are inherently difficult to replicate
Bhowmick, Rahul & Hickson, Ian David, 2017, In: F1000Research. 6, 7 p., 666.Research output: Contribution to journal › Review › Research › peer-review
- Published
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, Rahul, Marini, V., Ferrari, S., Hickson, Ian David, Krejci, L. & Janscak, P., 1 Jun 2017, In: Molecular Cell. 66, 5, p. 658-671.e8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells
Kessler, B. M., Bursomanno, S., McGouran, J. F., Hickson, Ian David & Liu, Ying, 2017, Activity-Based Proteomics: Methods and Protocols. Overkleeft, H. S. & Florea, B. I. (eds.). Humana Press, Vol. 1491. p. 131-144 14 p. (Methods in Molecular Biology, Vol. 1491).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Stalled replication forks generate a distinct mutational signature in yeast
Larsen, N. B., Liberti, S. E., Vogel, Ivan, Jorgensen, S. W., Hickson, Ian David & Mankouri, H. W., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. 9665-9670Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis
Natsume, T., Nishimura, K., Minocherhomji, S., Bhowmick, Rahul, Hickson, Ian David & Kanemaki, M. T., 2017, In: Genes & Development. 31, 8, p. 816-829 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel TPR-BEN domain interaction mediates PICH-BEND3 association
Pitchai, G. P., Kaulich, M., Bizard, A. H., Mesa, Pablo, Yao, Q., Sarlos, K., Streicher, W. W., Nigg, E. A., Montoya, Guillermo & Hickson, Ian David, 2017, In: Nucleic Acids Research. 19, 2, p. 11413–11424Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potential biomarkers of DNA replication stress in cancer
Ren, L., Chen, L., Wu, Wei, Garribba, L., Tian, H., Liu, Z., Vogel, Ivan, Li, C., Hickson, Ian David & Liu, Ying, 2017, In: OncoTarget. 8, 23, p. 36996-37008 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
Sarlós, K., Biebricher, A., Petermann, E. J. G., Wuite, G. J. L. & Hickson, Ian David, 2017, In: Cold Spring Harbor Laboratory. Symposia on Quantitative Biology. 82, p. 187-195Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Ahuja, A. K., Jodkowska, K., Teloni, F., Bizard, A. H., Zellweger, R., Herrador, R., Ortega, S., Hickson, Ian David, Altmeyer, M., Mendez, J. & Lopes, M., Feb 2016, In: Nature Communications. 7, 11 p., 10660.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress
Bhowmick, Rahul, Minocherhomji, S. & Hickson, Ian David, 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1117-1126 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Christensen, Christa Lykke, Helge, Jørn Wulff, Krasnik, Allan, Kriegbaum, Margit, Rasmussen, Lene Juel, Hickson, Ian David, Liisberg, Kasper Bering, Oxlund, Bjarke, Bruun, B., Lau, Sofie Rosenlund, Olsen, M. N. A., Andersen, John Sahl, Heltberg, Andreas Søndergaard, Kuhlman, A. C. B., Morville, T. H., Dohlmann, T. L., Larsen, Steen & Dela, Flemming, 2016, In: Scandinavian Journal of Public Health. 44, 5, p. 534-539 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation
Ghamrasni, S. E., Cardoso, R., Li, L., Guturi, K. K. N., Bjerregaard, Victoria Alexandra, Liu, Ying, Venkatesan, S., Hande, M. P., Henderson, J. T., Sanchez, O., Hickson, Ian David, Hakem, A. & Hakem, R., 15 Sep 2016, In: Oncogene. 35, 37, p. 4836-4845 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction
Nielsen, Christian Friberg & Hickson, Ian David, 17 Oct 2016, In: Cell Cycle. 15, 20, p. 2704-2711 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex
Pitchai, G. P., Hickson, Ian David, Streicher, W., Montoya, Guillermo & Mesa, Pablo, Aug 2016, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 72, 8, p. 646-651 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of SUMO2 Target Proteins by the Proteasome in Human Cells Exposed to Replication Stress
Bursomanno, S., McGouran, J. F., Kessler, B. M., Hickson, Ian David & Liu, Ying, 2015, In: Journal of Proteome Research. 14, 4, p. 1687-99 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
Chu, W. K., Payne, M. J., Beli, P., Hanada, K., Choudhary, C. & Hickson, Ian David, 2015, In: Nature Communications. 6, 7 p., 5931.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FBH1 Catalyzes Regression of Stalled Replication Forks
Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
Kliszczak, M., Sedlackova, H., Pitchai, G. P., Streicher, W. W., Krejci, L. & Hickson, Ian David, 1 Dec 2015, In: OncoTarget. 6, 38, p. 40464-79 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replication stress activates DNA repair synthesis in mitosis
Minocherhomji, S., Ying, S., Bjerregaard, Victoria Alexandra, Bursomanno, S., Aleliunaite, A., Wu, Wei, Mankouri, H. W., Shen, H., Liu, Ying & Hickson, Ian David, 10 Dec 2015, In: Nature. 528, 7581, p. 286-90 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
Newman, J. A., Savitsky, P., Allerston, C. K., Bizard, A. H., Özer, Ö., Sarlós, K., Liu, Ying, Pardon, E., Steyaert, J., Hickson, Ian David & Gileadi, O., 2015, In: Nucleic Acids Research. 43, 10, p. 5221-35 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis
Nielsen, Christian Friberg, Huttner, D., Bizard, A. H., Hirano, S., Li, T., Palmai-Pallag, T., Bjerregaard, Victoria Alexandra, Liu, Ying, Nigg, E. A., Wang, L. H. & Hickson, Ian David, 2015, In: Nature Communications. 6, 15 p., 8962.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response
Xing, M., Wang, X., Palmai-Pallag, T., Shen, H., Helleday, T., Hickson, Ian David & Ying, S., 2015, In: OncoTarget. 6, 35, p. 37638-37646 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair
Akbari, M., Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Desler, Claus, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In: DNA Repair. 16, p. 44-53 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Dissolution of Double Holliday Junctions
Bizard, A. H. & Hickson, Ian David, 1 Jul 2014, In: Cold Spring Harbor perspectives in biology. 6, p. 1-16 16 p., a016477.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1
Bocquet, N., Bizard, A. H., Abdulrahman, W., Larsen, N. B., Faty, M., Cavadini, S., Bunker, R. D., Kowalczykowski, S. C., Cejka, P., Hickson, Ian David & Thomä, N. H., Mar 2014, In: Nature Structural and Molecular Biology. 21, 3, p. 261-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures
Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, Ian David, Gileadi, O. & Rothenberg, E., 24 Nov 2014, In: Nature Communications. 5, p. 1-12 12 p., 5556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast
Larsen, N. B., Sass, E., Suski, C., Mankouri, H. W. & Hickson, Ian David, 2014, In: Nature Communications. 5, p. 1-10 10 p., 3574.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes
Larsen, N. B., Hickson, Ian David & Mankouri, H. W., 1 Oct 2014, In: Cell Cycle. 13, 19, p. 2994-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The origins and processing of ultra fine anaphase DNA bridges
Liu, Ying, Nielsen, Christian Friberg, Yao, Q. & Hickson, Ian David, 30 Apr 2014, In: Current Opinion in Genetics & Development. 26C, p. 1-5 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structure-specific endonucleases: guardians of fragile site stability
Minocherhomji, S. & Hickson, Ian David, May 2014, In: Trends in Cell Biology. 24, 5, p. 321-327 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs
Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Gray, L. T., Welsh, J. A., Schetter, A. J., Kumamoto, K., Wang, X. W., Hickson, Ian David, Maizels, N., Monnat, R. J. & Harris, C. C., 8 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9905-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA
Biebricher, A., Hirano, S., Enzlin, J., Wiechens, N., Streicher, W., Huttner, D., Wang, L., Nigg, E., Owen-Hughes, T., Liu, Ying, Peterman, E., Wuite, G. & Hickson, Ian David, 12 Sep 2013, In: Molecular Cell. 51, 5, p. 691-701 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress
Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining.
Grabarz, A., Guirouilh-Barbat, J., Barascu, A., Pennarun, G., Genet, D., Rass, E., Germann, S. M., Bertrand, P., Hickson, Ian David & Lopez, B. S., 17 Oct 2013, In: Cell Reports. 5, 1, p. 21-28 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RecQ Helicases: Conserved Guardians of Genomic Integrity
Larsen, N. B. & Hickson, Ian David, 2013, In: Advances in Experimental Medicine and Biology. 767, p. 161-84 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How unfinished business from S-phase affects mitosis and beyond
Mankouri, H. W., Huttner, D. & Hickson, Ian David, 16 Oct 2013, In: EMBO Journal. 32, 20, p. 2661-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In: Chemistry & Biology. 20, 1, p. 55-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase
Rosenthal, A. S., Dexheimer, T. S., Gileadi, O., Nguyen, G. H., Chu, W. K., Hickson, Ian David, Jadhav, A., Simeonov, A. & Maloney, D. J., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 20, p. 5660-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells
Simandlova, J., Zagelbaum, J., Payne, M. J., Chu, W. K., Shevelev, I., Hanada, K., Chatterjee, S., Reid, D. A., Liu, Ying, Janscak, P., Rothenberg, E. & Hickson, Ian David, 22 Nov 2013, In: The Journal of Biological Chemistry. 288, 47, p. 34168-80 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MUS81 promotes common fragile site expression
Ying, S., Minocherhomji, S., Chan, K. L., Palmai-Pallag, T., Chu, W. K., Wass, T. A., Mankouri, H. W., Liu, Ying & Hickson, Ian David, Aug 2013, In: Nature Cell Biology. 15, 8, p. 1001-1007 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
A novel antirecombinase gains PARIty
Mankouri, H. W., Chu, W. K. & Hickson, Ian David, Jan 2012, In: Molecular Cell. 45, 1, p. 6-7 2 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
BLM and RMI1 Alleviate RPA Inhibition of TopoIIIa Decatenase Activity
Yang, J., Bachrati, C. Z., Hickson, Ian David & Brown, G. W., Jul 2012, In: P L o S One. 7, 7, p. e41208Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae
Ashton, T. M., Mankouri, H. W., Heidenblut, A., McHugh, P. J. & Hickson, Ian David, 1 May 2011, In: Molecular and Cellular Biology. 31, 9, p. 1921-33 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights into the formation and resolution of ultra-fine anaphase bridges
Chan, K. L. & Hickson, Ian David, Oct 2011, In: Seminars in Cell and Developmental Biology. 22, 8, p. 906-12 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination
Eppink, B., Tafel, A. A., Hanada, K., van Drunen, E., Hickson, Ian David, Essers, J. & Kanaar, R., Nov 2011, In: D N A Repair. 10, 11, p. 1095-105 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes
Hickson, Ian David & Mankouri, H. W., Oct 2011, In: Cell Cycle. 10, 18, p. 3078-85 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage
Mankouri, H. W., Ashton, T. M. & Hickson, Ian David, 22 Mar 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 12, p. 4944-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
Mohammed, M. Z., Vyjayanti, V. N., Laughton, C. A., Dekker, L. V., Fischer, P. M., Wilson, D. M., Abbotts, R., Shah, S., Patel, P. M., Hickson, Ian David & Madhusudan, S., 15 Feb 2011, In: British Journal of Cancer Management. 104, 4, p. 653-63 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
Suhasini, A. N., Rawtani, N. A., Wu, Y., Sommers, J. A., Sharma, S., Mosedale, G., North, P. S., Cantor, S. B., Hickson, Ian David & Brosh, R. M., 16 Feb 2011, In: E M B O Journal. 30, 4, p. 692-705 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis
Ying, S. & Hickson, Ian David, 1 Apr 2011, In: U H O D. 93, 4, p. 440-5 6 p.Research output: Contribution to journal › Review › Research › peer-review
- 2010
- Published
Yeast as a model system to study RecQ helicase function
Ashton, T. M. & Hickson, Ian David, 2010, In: DNA Repair. 9, 3, p. 303-14 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3
Cejka, P., Plank, J. L., Bachrati, C. Z., Hickson, Ian David & Kowalczykowski, S. C., 1 Nov 2010, In: Nature Structural & Molecular Biology. 17, 11, p. 1377-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells
Chu, W. K., Hanada, K., Kanaar, R. & Hickson, Ian David, 19 Aug 2010, In: Oncogene. 29, 33, p. 4705-14 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown
Higgins, G. S., Prevo, R., Lee, Y., Helleday, T., Muschel, R. J., Taylor, S., Yoshimura, M., Hickson, Ian David, Bernhard, E. J. & McKenna, W. G., Apr 2010, In: Cancer Research. 70, 7, p. 2984-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha
Mönnich, M., Hess, I., Wiest, W., Bachrati, C., Hickson, Ian David, Schorpp, M. & Boehm, T., Sep 2010, In: European Journal of Immunology. 40, 9, p. 2379-84 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1
Yang, J., Bachrati, C. Z., Ou, J., Hickson, Ian David & Brown, G. W., 2010, In: Journal of Biological Chemistry. 285, 28, p. 21426-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
RecQ helicases: multifunctional genome caretakers
Chu, W. K. & Hickson, Ian David, 2009, In: Nature Reviews. Cancer. 9, p. 644-654 11 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 17446319
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
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A novel TPR-BEN domain interaction mediates PICH-BEND3 association
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Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
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