Ian David Hickson
Professor
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Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.Research output: Contribution to journal › Journal article › Research › peer-review
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A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Ahuja, A. K., Jodkowska, K., Teloni, F., Bizard, A. H., Zellweger, R., Herrador, R., Ortega, S., Hickson, Ian David, Altmeyer, M., Mendez, J. & Lopes, M., Feb 2016, In: Nature Communications. 7, 11 p., 10660.Research output: Contribution to journal › Journal article › Research › peer-review
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Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair
Akbari, M., Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Desler, Claus, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In: DNA Repair. 16, p. 44-53 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
Albers, E., Sbroggiò, M., Pladevall Morera, David, Bizard, A. H., Avram, Alexandra Ioana, Gonzalez, P., Martin Gonzalez, Javier, Hickson, Ian David & Lopez-Contreras, Andres, 2018, In: Cell Reports. 24, 12, p. 3274-3284 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Yeast as a model system to study RecQ helicase function
Ashton, T. M. & Hickson, Ian David, 2010, In: DNA Repair. 9, 3, p. 303-14 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae
Ashton, T. M., Mankouri, H. W., Heidenblut, A., McHugh, P. J. & Hickson, Ian David, 1 May 2011, In: Molecular and Cellular Biology. 31, 9, p. 1921-33 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
Bakx, J. A. M., Biebricher, A. S., King, G. A., Christodoulis, P., Sarlós, K., Bizard, A. H., Hickson, Ian David, Wuite, G. J. L. & Peterman, E. J. G., 2022, In: Nature Communications. 13, 1, 584.Research output: Contribution to journal › Journal article › Research › peer-review
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RAD51 protects human cells from transcription-replication conflicts
Bhowmick, Rahul, Lerdrup, Mads, Gadi, Sampath Amitash, Rossetti, G. G., Singh, Manika Indrajit, Liu, Ying, Halazonetis, T. D. & Hickson, Ian David, 2022, In: Molecular Cell. 82, 18, p. 3366-3381.e9Research output: Contribution to journal › Journal article › Research › peer-review
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The "enemies within": regions of the genome that are inherently difficult to replicate
Bhowmick, Rahul & Hickson, Ian David, 2017, In: F1000Research. 6, 7 p., 666.Research output: Contribution to journal › Review › Research › peer-review
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Completing genome replication outside of S phase
Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2023, In: Molecular Cell. 83, 20, p. 3596-3607 12 p.Research output: Contribution to journal › Review › Research › peer-review
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RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress
Bhowmick, Rahul, Minocherhomji, S. & Hickson, Ian David, 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1117-1126 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The RIF1-PP1 Axis Controls Abscission Timing in Human Cells
Bhowmick, Rahul, Thakur, R. S., Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In: Current Biology. 29, 7, p. 1232-1242.e5Research output: Contribution to journal › Journal article › Research › peer-review
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PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA
Biebricher, A., Hirano, S., Enzlin, J., Wiechens, N., Streicher, W., Huttner, D., Wang, L., Nigg, E., Owen-Hughes, T., Liu, Ying, Peterman, E., Wuite, G. & Hickson, Ian David, 12 Sep 2013, In: Molecular Cell. 51, 5, p. 691-701 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Detection of Ultrafine Anaphase Bridges
Bizard, A. H., Nielsen, Christian Friberg & Hickson, Ian David, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 495-508 14 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Anaphase: a fortune-teller of genomic instability
Bizard, A. H. & Hickson, Ian David, Jun 2018, In: Current Opinion in Cell Biology. 52, p. 112-119 8 p.Research output: Contribution to journal › Review › Research › peer-review
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The Dissolution of Double Holliday Junctions
Bizard, A. H. & Hickson, Ian David, 1 Jul 2014, In: Cold Spring Harbor perspectives in biology. 6, p. 1-16 16 p., a016477.Research output: Contribution to journal › Review › Research › peer-review
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The many lives of type IA topoisomerases
Bizard, A. H. & Hickson, Ian David, 2020, In: Journal of Biological Chemistry. 295, 20, p. 7138-7153 16 p.Research output: Contribution to journal › Review › Research › peer-review
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PICH and TOP3A cooperate to induce positive DNA supercoiling
Bizard, A. H., Allemand, J. F., Hassenkam, Tue, Paramasivam, M., Sarlós, K., Singh, Manika Indrajit & Hickson, Ian David, 2019, In: Nature Structural and Molecular Biology. 26, 4, p. 267-274 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Folate deficiency drives mitotic missegregation of the human FRAXA locus
Bjerregaard, Victoria Alexandra, Garribba, L., McMurray, C. T., Hickson, Ian David & Liu, Ying, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 13003-13008 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Detection and Analysis of Chromosome Fragile Sites
Bjerregaard, Victoria Alexandra, Özer, Ö., Hickson, Ian David & Liu, Ying, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 471-482 12 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1
Bocquet, N., Bizard, A. H., Abdulrahman, W., Larsen, N. B., Faty, M., Cavadini, S., Bunker, R. D., Kowalczykowski, S. C., Cejka, P., Hickson, Ian David & Thomä, N. H., Mar 2014, In: Nature Structural and Molecular Biology. 21, 3, p. 261-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Bagge, Keerthana Stine Viswalingam, Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of SUMO2 Target Proteins by the Proteasome in Human Cells Exposed to Replication Stress
Bursomanno, S., McGouran, J. F., Kessler, B. M., Hickson, Ian David & Liu, Ying, 2015, In: Journal of Proteome Research. 14, 4, p. 1687-99 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumour predisposition and cancer syndromes as models to study gene–environment interactions
Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, , 2020, In: Nature Reviews Cancer. 20, p. 533–549Research output: Contribution to journal › Journal article › Research › peer-review
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PICH deficiency limits the progression of MYC-induced B-cell lymphoma
Castejón-Griñán, M., Albers, E., Simón-Carrasco, L., Aguilera, P., Sbroggio, M., Pladevall Morera, David, Ingham, Andreas, Lim, Ernest Wee Kiat, Guillen-Benitez, A., Pietrini, E., Lisby, Michael, Hickson, Ian David & Lopez-Contreras, Andres, 2024, In: Blood Cancer Journal. 14, 1, 15 p., 16.Research output: Contribution to journal › Journal article › Research › peer-review
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Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3
Cejka, P., Plank, J. L., Bachrati, C. Z., Hickson, Ian David & Kowalczykowski, S. C., 1 Nov 2010, In: Nature Structural & Molecular Biology. 17, 11, p. 1377-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New insights into the formation and resolution of ultra-fine anaphase bridges
Chan, K. L. & Hickson, Ian David, Oct 2011, In: Seminars in Cell and Developmental Biology. 22, 8, p. 906-12 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures
Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, Ian David, Gileadi, O. & Rothenberg, E., 24 Nov 2014, In: Nature Communications. 5, p. 1-12 12 p., 5556.Research output: Contribution to journal › Journal article › Research › peer-review
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Christensen, Christa Lykke, Helge, Jørn Wulff, Krasnik, Allan, Kriegbaum, Margit, Rasmussen, Lene Juel, Hickson, Ian David, Liisberg, Kasper Bering, Oxlund, Bjarke, Bruun, B., Lau, Sofie Rosenlund, Olsen, M. N. A., Andersen, John Sahl, Heltberg, Andreas Søndergaard, Kuhlman, A. C. B., Morville, T. H., Dohlmann, T. L., Larsen, Steen & Dela, Flemming, 2016, In: Scandinavian Journal of Public Health. 44, 5, p. 534-539 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells
Chu, W. K., Hanada, K., Kanaar, R. & Hickson, Ian David, 19 Aug 2010, In: Oncogene. 29, 33, p. 4705-14 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RecQ helicases: multifunctional genome caretakers
Chu, W. K. & Hickson, Ian David, 2009, In: Nature Reviews. Cancer. 9, p. 644-654 11 p.Research output: Contribution to journal › Review › Research › peer-review
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FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
Chu, W. K., Payne, M. J., Beli, P., Hanada, K., Choudhary, C. & Hickson, Ian David, 2015, In: Nature Communications. 6, 7 p., 5931.Research output: Contribution to journal › Journal article › Research › peer-review
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BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
Danino, Y. M., Molitor, L., Rosenbaum-Cohen, T., Kaiser, Sebastian, Cohen, Y., Porat, Z., Marmor-Kollet, H., Katina, C., Savidor, A., Rotkopf, R., Ben-Isaac, E., Golani, O., Levin, Y., Monchaud, D., Hickson, Ian David & Hornstein, E., 2023, In: Nucleic Acids Research. 51, 17, p. 9369-9384 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, Rahul, Marini, V., Ferrari, S., Hickson, Ian David, Krejci, L. & Janscak, P., 1 Jun 2017, In: Molecular Cell. 66, 5, p. 658-671.e8Research output: Contribution to journal › Journal article › Research › peer-review
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Simvastatin improves mitochondrial respiration in peripheral blood cells
Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.Research output: Contribution to journal › Journal article › Research › peer-review
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The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination
Eppink, B., Tafel, A. A., Hanada, K., van Drunen, E., Hickson, Ian David, Essers, J. & Kanaar, R., Nov 2011, In: D N A Repair. 10, 11, p. 1095-105 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress
Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423Research output: Contribution to journal › Journal article › Research › peer-review
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FBH1 Catalyzes Regression of Stalled Replication Forks
Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.Research output: Contribution to journal › Journal article › Research › peer-review
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Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells
Garribba, L., Bjerregaard, Victoria Alexandra, Gonçalves Dinis, M. M., Özer, Ö., Wu, Wei, Sakellariou, D., Pena-Diaz, J., Hickson, Ian David & Liu, Ying, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 28, p. 16527-16536 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci
Garribba, L., Wu, Wei, Özer, Ö., Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2018, Methods in Enzymology: Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Spies, M. & Malkova, A. (eds.). Elsevier, Vol. 601. p. 45-58 14 p. (Methods in Enzymology; No. 601).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response
Geng, X., Zhang, C., Li, M., Wang, J., Ji, F., Feng, H., Xing, M., Li, F., Zhang, L., Li, W., Chen, Z., Hickson, Ian David, Shen, H. & Ying, S., 2022, In: Advanced Science. 9, 7, 2103837.Research output: Contribution to journal › Journal article › Research › peer-review
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Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation
Ghamrasni, S. E., Cardoso, R., Li, L., Guturi, K. K. N., Bjerregaard, Victoria Alexandra, Liu, Ying, Venkatesan, S., Hande, M. P., Henderson, J. T., Sanchez, O., Hickson, Ian David, Hakem, A. & Hakem, R., 15 Sep 2016, In: Oncogene. 35, 37, p. 4836-4845 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining.
Grabarz, A., Guirouilh-Barbat, J., Barascu, A., Pennarun, G., Genet, D., Rass, E., Germann, S. M., Bertrand, P., Hickson, Ian David & Lopez, B. S., 17 Oct 2013, In: Cell Reports. 5, 1, p. 21-28 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313Research output: Contribution to journal › Journal article › Research › peer-review
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Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes
Hickson, Ian David & Mankouri, H. W., Oct 2011, In: Cell Cycle. 10, 18, p. 3078-85 8 p.Research output: Contribution to journal › Review › Research › peer-review
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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown
Higgins, G. S., Prevo, R., Lee, Y., Helleday, T., Muschel, R. J., Taylor, S., Yoshimura, M., Hickson, Ian David, Bernhard, E. J. & McKenna, W. G., Apr 2010, In: Cancer Research. 70, 7, p. 2984-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Esc2 promotes telomere stability in response to DNA replication stress
Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells
Kessler, B. M., Bursomanno, S., McGouran, J. F., Hickson, Ian David & Liu, Ying, 2017, Activity-Based Proteomics: Methods and Protocols. Overkleeft, H. S. & Florea, B. I. (eds.). Humana Press, Vol. 1491. p. 131-144 14 p. (Methods in Molecular Biology, Vol. 1491).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
Kliszczak, M., Sedlackova, H., Pitchai, G. P., Streicher, W. W., Krejci, L. & Hickson, Ian David, 1 Dec 2015, In: OncoTarget. 6, 38, p. 40464-79 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 17446319
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Research output: Contribution to journal › Journal article › Research › peer-review
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A novel TPR-BEN domain interaction mediates PICH-BEND3 association
Research output: Contribution to journal › Journal article › Research › peer-review
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239
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Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase
Research output: Contribution to journal › Journal article › Research › peer-review
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