Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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- Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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Venegas et al. employ an auxin-inducible degron system for different subunits of the SMC5/6 complex to interrogate the short- and long-term effects of SMC5/6 impairment in human cells. Degradation of SMC5/6’s subunits at different cell cycle stages places the essential role of the complex during S phase.
Original language | English |
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Article number | 107533 |
Journal | Cell Reports |
Volume | 31 |
Issue number | 3 |
Number of pages | 20 |
ISSN | 2211-1247 |
DOIs | |
Publication status | Published - 2020 |
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