White matter lactate - Publication List

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White matter lactate: Does it matter?

Research output: Contribution to journal › Review › Research › peer-review

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White matter lactate : Does it matter? / Rinholm, J E; Bergersen, Linda Hildegard.

In: Neuroscience, Vol. 276, 2014, p. 109-116.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rinholm, JE & Bergersen, LH 2014, 'White matter lactate: Does it matter?', Neuroscience, vol. 276, pp. 109-116. https://doi.org/10.1016/j.neuroscience.2013.10.002

APA

Rinholm, J. E., & Bergersen, L. H. (2014). White matter lactate: Does it matter? Neuroscience, 276, 109-116. https://doi.org/10.1016/j.neuroscience.2013.10.002

Vancouver

Rinholm JE, Bergersen LH. White matter lactate: Does it matter? Neuroscience. 2014;276:109-116. https://doi.org/10.1016/j.neuroscience.2013.10.002

Author

Rinholm, J E ; Bergersen, Linda Hildegard. / White matter lactate : Does it matter?. In: Neuroscience. 2014 ; Vol. 276. pp. 109-116.

Bibtex

@article{3e4ccf44fb234fc99a0e38beaf9ef92a,

title = "White matter lactate: Does it matter?",

abstract = "About half of the human brain is white matter, characterized by axons covered in myelin, which facilitates the high speed of nerve signals from one brain area to another. At the time of myelination, the oligodendrocytes that synthesize myelin require a large amount of energy for this task. Conditions that deprive the tissue of energy can kill the oligodendrocytes. During brain development, the oligodendrocytes may use lactate as an alternative source of energy and material for myelin formation. Mature oligodendrocytes, however, can release lactate through the myelin sheath as nutrient for axons. In addition, lactate carries signals as a volume transmitter. Myelin thus seems to serve as a provider of substrates and signals for axons, and not as a mere insulator. We review the fluxes of lactate in white matter and their significance in brain function. ",

keywords = "Animals, Axons/metabolism, Humans, Lactic Acid/metabolism, Myelin Sheath/metabolism, Oligodendroglia/metabolism, Signal Transduction, White Matter/metabolism",

author = "Rinholm, {J E} and Bergersen, {Linda Hildegard}",

year = "2014",

doi = "10.1016/j.neuroscience.2013.10.002",

language = "English",

volume = "276",

pages = "109--116",

journal = "Neuroscience",

issn = "0306-4522",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - White matter lactate

T2 - Does it matter?

AU - Rinholm, J E

AU - Bergersen, Linda Hildegard

PY - 2014

Y1 - 2014

N2 - About half of the human brain is white matter, characterized by axons covered in myelin, which facilitates the high speed of nerve signals from one brain area to another. At the time of myelination, the oligodendrocytes that synthesize myelin require a large amount of energy for this task. Conditions that deprive the tissue of energy can kill the oligodendrocytes. During brain development, the oligodendrocytes may use lactate as an alternative source of energy and material for myelin formation. Mature oligodendrocytes, however, can release lactate through the myelin sheath as nutrient for axons. In addition, lactate carries signals as a volume transmitter. Myelin thus seems to serve as a provider of substrates and signals for axons, and not as a mere insulator. We review the fluxes of lactate in white matter and their significance in brain function.

AB - About half of the human brain is white matter, characterized by axons covered in myelin, which facilitates the high speed of nerve signals from one brain area to another. At the time of myelination, the oligodendrocytes that synthesize myelin require a large amount of energy for this task. Conditions that deprive the tissue of energy can kill the oligodendrocytes. During brain development, the oligodendrocytes may use lactate as an alternative source of energy and material for myelin formation. Mature oligodendrocytes, however, can release lactate through the myelin sheath as nutrient for axons. In addition, lactate carries signals as a volume transmitter. Myelin thus seems to serve as a provider of substrates and signals for axons, and not as a mere insulator. We review the fluxes of lactate in white matter and their significance in brain function.

KW - Animals

KW - Axons/metabolism

KW - Humans

KW - Lactic Acid/metabolism

KW - Myelin Sheath/metabolism

KW - Oligodendroglia/metabolism

KW - Signal Transduction

KW - White Matter/metabolism

U2 - 10.1016/j.neuroscience.2013.10.002

DO - 10.1016/j.neuroscience.2013.10.002

M3 - Review

C2 - 24125892

VL - 276

SP - 109

EP - 116

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 202776079