UTE T2* mapping of tendinopathic patellar tendons: an MRI reproducibility study
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UTE T2* mapping of tendinopathic patellar tendons : an MRI reproducibility study. / Agergaard, Anne Sofie; Malmgaard-Clausen, Nikolaj M.; Svensson, Rene B.; Nybing, Janus D.; Boesen, Mikael; Kjaer, Michael; Magnusson, S. Peter; Hansen, Philip.
In: Acta Radiologica, Vol. 62, No. 2, 2021, p. 215-224.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - UTE T2* mapping of tendinopathic patellar tendons
T2 - an MRI reproducibility study
AU - Agergaard, Anne Sofie
AU - Malmgaard-Clausen, Nikolaj M.
AU - Svensson, Rene B.
AU - Nybing, Janus D.
AU - Boesen, Mikael
AU - Kjaer, Michael
AU - Magnusson, S. Peter
AU - Hansen, Philip
N1 - Publisher Copyright: © The Foundation Acta Radiologica 2020.
PY - 2021
Y1 - 2021
N2 - Background: There is currently a lack of imaging modalities that can be used as a sensitive measure in tendinopathy. Recent findings suggest the applicability of ultra-short echo time (UTE) magnetic resonance imaging (MRI) T2* mapping in tendons, but the reproducibility remains unknown. Purpose: To evaluate test–retest reproducibility of UTE MRI T2* mapping of tendinopathic patellar tendons and to evaluate the intra- and inter-observer reproducibility of the measurement. Material and Methods: Fifteen patients with chronic patellar tendinopathy were evaluated with UTE MRI twice in a 3.0-T scanner on the same day. Manual segmentation of the patellar tendon was performed by two blinded investigators and automated T2*map reconstruction was performed in custom-made software. Results: There was a significant and numerically small difference in test–retest T2* values (T2*meandiff = 0.06 ± 0.07 ms ≈ 3.7%; P = 0.006) with an ICC = 0.91 (95% confidence interval [CI] 0.58–0.98; typical error of 3.0%). The intra- and inter-observer reproducibility showed no significant bias (P = 0.493 and P = 0.052), and generally substantial reproducibility was demonstrated for T2* (intra-observer ICC = 0.99; 95% CI 0.98–1.00 and inter-observer ICC = 0.99; 95% CI 0.96–1.00, and typical error 1.3% and 1.3%, respectively). Conclusion: These data demonstrate a small bias between repeated measurements for UTE T2*, but with a very low associated mean difference (3.7%) between the two tests. The high ICC values and low typical error % demonstrate reproducibility of repeated T2*-mapping sessions. Further, the method showed substantial intra- and inter-observer reproducibility for T2* values proving feasibility for use of UTE T2* mapping in research and clinical practice.
AB - Background: There is currently a lack of imaging modalities that can be used as a sensitive measure in tendinopathy. Recent findings suggest the applicability of ultra-short echo time (UTE) magnetic resonance imaging (MRI) T2* mapping in tendons, but the reproducibility remains unknown. Purpose: To evaluate test–retest reproducibility of UTE MRI T2* mapping of tendinopathic patellar tendons and to evaluate the intra- and inter-observer reproducibility of the measurement. Material and Methods: Fifteen patients with chronic patellar tendinopathy were evaluated with UTE MRI twice in a 3.0-T scanner on the same day. Manual segmentation of the patellar tendon was performed by two blinded investigators and automated T2*map reconstruction was performed in custom-made software. Results: There was a significant and numerically small difference in test–retest T2* values (T2*meandiff = 0.06 ± 0.07 ms ≈ 3.7%; P = 0.006) with an ICC = 0.91 (95% confidence interval [CI] 0.58–0.98; typical error of 3.0%). The intra- and inter-observer reproducibility showed no significant bias (P = 0.493 and P = 0.052), and generally substantial reproducibility was demonstrated for T2* (intra-observer ICC = 0.99; 95% CI 0.98–1.00 and inter-observer ICC = 0.99; 95% CI 0.96–1.00, and typical error 1.3% and 1.3%, respectively). Conclusion: These data demonstrate a small bias between repeated measurements for UTE T2*, but with a very low associated mean difference (3.7%) between the two tests. The high ICC values and low typical error % demonstrate reproducibility of repeated T2*-mapping sessions. Further, the method showed substantial intra- and inter-observer reproducibility for T2* values proving feasibility for use of UTE T2* mapping in research and clinical practice.
KW - Patellar tendon
KW - reproducibility
KW - T2 mapping
KW - tendinopathy
KW - ultra-short echo time imaging
U2 - 10.1177/0284185120918807
DO - 10.1177/0284185120918807
M3 - Journal article
C2 - 32340475
AN - SCOPUS:85084853803
VL - 62
SP - 215
EP - 224
JO - Acta Radiologica - Series Diagnosis
JF - Acta Radiologica - Series Diagnosis
SN - 0365-5954
IS - 2
ER -
ID: 278494715