Molecular anatomy of adult mouse leptomeninges

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Molecular anatomy of adult mouse leptomeninges. / Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael; Muhl, Lars; Mocci, Giuseppe; Bjørnholm, Katrine D.; Lindblad, Caroline; Fletcher-Sandersjöö, Alexander; Svensson, Mikael; Thelin, Eric P.; Liu, Jianping; van Voorden, A. Jantine; Torres, Monica; Antila, Salli; Xin, Li; Karlström, Helena; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Moggio, Aldo; Hansson, Emil M.; Ulvmar, Maria H.; Nilsson, Per; Mäkinen, Taija; Andaloussi Mäe, Maarja; Alitalo, Kari; Proulx, Steven T.; Engelhardt, Britta; McDonald, Donald M.; Lendahl, Urban; Andrae, Johanna; Betsholtz, Christer.

In: Neuron, Vol. 111, No. 23, 2023, p. 3745-3764.e.1-e7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pietilä, R, Del Gaudio, F, He, L, Vázquez-Liébanas, E, Vanlandewijck, M, Muhl, L, Mocci, G, Bjørnholm, KD, Lindblad, C, Fletcher-Sandersjöö, A, Svensson, M, Thelin, EP, Liu, J, van Voorden, AJ, Torres, M, Antila, S, Xin, L, Karlström, H, Storm-Mathisen, J, Bergersen, LH, Moggio, A, Hansson, EM, Ulvmar, MH, Nilsson, P, Mäkinen, T, Andaloussi Mäe, M, Alitalo, K, Proulx, ST, Engelhardt, B, McDonald, DM, Lendahl, U, Andrae, J & Betsholtz, C 2023, 'Molecular anatomy of adult mouse leptomeninges', Neuron, vol. 111, no. 23, pp. 3745-3764.e.1-e7. https://doi.org/10.1016/j.neuron.2023.09.002

APA

Pietilä, R., Del Gaudio, F., He, L., Vázquez-Liébanas, E., Vanlandewijck, M., Muhl, L., Mocci, G., Bjørnholm, K. D., Lindblad, C., Fletcher-Sandersjöö, A., Svensson, M., Thelin, E. P., Liu, J., van Voorden, A. J., Torres, M., Antila, S., Xin, L., Karlström, H., Storm-Mathisen, J., ... Betsholtz, C. (2023). Molecular anatomy of adult mouse leptomeninges. Neuron, 111(23), 3745-3764.e.1-e7. https://doi.org/10.1016/j.neuron.2023.09.002

Vancouver

Pietilä R, Del Gaudio F, He L, Vázquez-Liébanas E, Vanlandewijck M, Muhl L et al. Molecular anatomy of adult mouse leptomeninges. Neuron. 2023;111(23):3745-3764.e.1-e7. https://doi.org/10.1016/j.neuron.2023.09.002

Author

Pietilä, Riikka ; Del Gaudio, Francesca ; He, Liqun ; Vázquez-Liébanas, Elisa ; Vanlandewijck, Michael ; Muhl, Lars ; Mocci, Giuseppe ; Bjørnholm, Katrine D. ; Lindblad, Caroline ; Fletcher-Sandersjöö, Alexander ; Svensson, Mikael ; Thelin, Eric P. ; Liu, Jianping ; van Voorden, A. Jantine ; Torres, Monica ; Antila, Salli ; Xin, Li ; Karlström, Helena ; Storm-Mathisen, Jon ; Bergersen, Linda Hildegard ; Moggio, Aldo ; Hansson, Emil M. ; Ulvmar, Maria H. ; Nilsson, Per ; Mäkinen, Taija ; Andaloussi Mäe, Maarja ; Alitalo, Kari ; Proulx, Steven T. ; Engelhardt, Britta ; McDonald, Donald M. ; Lendahl, Urban ; Andrae, Johanna ; Betsholtz, Christer. / Molecular anatomy of adult mouse leptomeninges. In: Neuron. 2023 ; Vol. 111, No. 23. pp. 3745-3764.e.1-e7.

Bibtex

@article{9f3dfa5ea4e6429293d0c79a5e0eb595,

title = "Molecular anatomy of adult mouse leptomeninges",

abstract = "Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically distinct cell types of the pia, inner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibroblast-like transcriptome present in the choroid plexus and median eminence. Newly identified transcriptional markers enabled molecular characterization of cell types responsible for adherence of arachnoid layers to one another and for the arachnoid barrier. These markers also proved useful in identifying the molecular features of leptomeningeal development, injury, and repair that were preserved or changed after traumatic brain injury. Together, the findings highlight the value of identifying fibroblast transcriptional subsets and their cellular locations toward advancing the understanding of leptomeningeal physiology and pathology.",

keywords = "arachnoid barrier, arachnoid mater, brain fibroblasts, dura mater, leptomeninges, perivascular fibroblast, pia mater, single-cell RNA sequencing, traumatic brain injury, tricellular junction",

author = "Riikka Pietil{\"a} and {Del Gaudio}, Francesca and Liqun He and Elisa V{\'a}zquez-Li{\'e}banas and Michael Vanlandewijck and Lars Muhl and Giuseppe Mocci and Bj{\o}rnholm, {Katrine D.} and Caroline Lindblad and Alexander Fletcher-Sandersj{\"o}{\"o} and Mikael Svensson and Thelin, {Eric P.} and Jianping Liu and {van Voorden}, {A. Jantine} and Monica Torres and Salli Antila and Li Xin and Helena Karlstr{\"o}m and Jon Storm-Mathisen and Bergersen, {Linda Hildegard} and Aldo Moggio and Hansson, {Emil M.} and Ulvmar, {Maria H.} and Per Nilsson and Taija M{\"a}kinen and {Andaloussi M{\"a}e}, Maarja and Kari Alitalo and Proulx, {Steven T.} and Britta Engelhardt and McDonald, {Donald M.} and Urban Lendahl and Johanna Andrae and Christer Betsholtz",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

doi = "10.1016/j.neuron.2023.09.002",

language = "English",

volume = "111",

pages = "3745--3764.e.1--e7",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "23",

}

RIS

TY - JOUR

T1 - Molecular anatomy of adult mouse leptomeninges

AU - Pietilä, Riikka

AU - Del Gaudio, Francesca

AU - He, Liqun

AU - Vázquez-Liébanas, Elisa

AU - Vanlandewijck, Michael

AU - Muhl, Lars

AU - Mocci, Giuseppe

AU - Bjørnholm, Katrine D.

AU - Lindblad, Caroline

AU - Fletcher-Sandersjöö, Alexander

AU - Svensson, Mikael

AU - Thelin, Eric P.

AU - Liu, Jianping

AU - van Voorden, A. Jantine

AU - Torres, Monica

AU - Antila, Salli

AU - Xin, Li

AU - Karlström, Helena

AU - Storm-Mathisen, Jon

AU - Bergersen, Linda Hildegard

AU - Moggio, Aldo

AU - Hansson, Emil M.

AU - Ulvmar, Maria H.

AU - Nilsson, Per

AU - Mäkinen, Taija

AU - Andaloussi Mäe, Maarja

AU - Alitalo, Kari

AU - Proulx, Steven T.

AU - Engelhardt, Britta

AU - McDonald, Donald M.

AU - Lendahl, Urban

AU - Andrae, Johanna

AU - Betsholtz, Christer

PY - 2023

Y1 - 2023

N2 - Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically distinct cell types of the pia, inner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibroblast-like transcriptome present in the choroid plexus and median eminence. Newly identified transcriptional markers enabled molecular characterization of cell types responsible for adherence of arachnoid layers to one another and for the arachnoid barrier. These markers also proved useful in identifying the molecular features of leptomeningeal development, injury, and repair that were preserved or changed after traumatic brain injury. Together, the findings highlight the value of identifying fibroblast transcriptional subsets and their cellular locations toward advancing the understanding of leptomeningeal physiology and pathology.

AB - Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically distinct cell types of the pia, inner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibroblast-like transcriptome present in the choroid plexus and median eminence. Newly identified transcriptional markers enabled molecular characterization of cell types responsible for adherence of arachnoid layers to one another and for the arachnoid barrier. These markers also proved useful in identifying the molecular features of leptomeningeal development, injury, and repair that were preserved or changed after traumatic brain injury. Together, the findings highlight the value of identifying fibroblast transcriptional subsets and their cellular locations toward advancing the understanding of leptomeningeal physiology and pathology.

KW - arachnoid barrier

KW - arachnoid mater

KW - brain fibroblasts

KW - dura mater

KW - leptomeninges

KW - perivascular fibroblast

KW - pia mater

KW - single-cell RNA sequencing

KW - traumatic brain injury

KW - tricellular junction

U2 - 10.1016/j.neuron.2023.09.002

DO - 10.1016/j.neuron.2023.09.002

M3 - Journal article

C2 - 37776854

AN - SCOPUS:85174217401

VL - 111

SP - 3745-3764.e.1-e7

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 23

ER -

ID: 389599837

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