Mitophagy and Neuroprotection

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Mitophagy and Neuroprotection. / Lou, Guofeng; Palikaras, Konstantinos; Lautrup, Sofie; Scheibye-Knudsen, Morten; Tavernarakis, Nektarios; Fang, Evandro F.

In: Trends in Molecular Medicine, Vol. 26, No. 1, 2020, p. 8-20.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lou, G, Palikaras, K, Lautrup, S, Scheibye-Knudsen, M, Tavernarakis, N & Fang, EF 2020, 'Mitophagy and Neuroprotection', Trends in Molecular Medicine, vol. 26, no. 1, pp. 8-20. https://doi.org/10.1016/j.molmed.2019.07.002

APA

Lou, G., Palikaras, K., Lautrup, S., Scheibye-Knudsen, M., Tavernarakis, N., & Fang, E. F. (2020). Mitophagy and Neuroprotection. Trends in Molecular Medicine, 26(1), 8-20. https://doi.org/10.1016/j.molmed.2019.07.002

Vancouver

Lou G, Palikaras K, Lautrup S, Scheibye-Knudsen M, Tavernarakis N, Fang EF. Mitophagy and Neuroprotection. Trends in Molecular Medicine. 2020;26(1):8-20. https://doi.org/10.1016/j.molmed.2019.07.002

Author

Lou, Guofeng ; Palikaras, Konstantinos ; Lautrup, Sofie ; Scheibye-Knudsen, Morten ; Tavernarakis, Nektarios ; Fang, Evandro F. / Mitophagy and Neuroprotection. In: Trends in Molecular Medicine. 2020 ; Vol. 26, No. 1. pp. 8-20.

Bibtex

@article{935b40f31bca451087c31aa52ea78bae,
title = "Mitophagy and Neuroprotection",
abstract = "Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.",
keywords = "ageing, Alzheimer's disease, amyotrophic lateral sclerosis, energy homeostasis, mitochondria, mitophagy, neurodegeneration, Parkinson's disease",
author = "Guofeng Lou and Konstantinos Palikaras and Sofie Lautrup and Morten Scheibye-Knudsen and Nektarios Tavernarakis and Fang, {Evandro F.}",
year = "2020",
doi = "10.1016/j.molmed.2019.07.002",
language = "English",
volume = "26",
pages = "8--20",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Ltd. * Trends Journals",
number = "1",

}

RIS

TY - JOUR

T1 - Mitophagy and Neuroprotection

AU - Lou, Guofeng

AU - Palikaras, Konstantinos

AU - Lautrup, Sofie

AU - Scheibye-Knudsen, Morten

AU - Tavernarakis, Nektarios

AU - Fang, Evandro F.

PY - 2020

Y1 - 2020

N2 - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

AB - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

KW - ageing

KW - Alzheimer's disease

KW - amyotrophic lateral sclerosis

KW - energy homeostasis

KW - mitochondria

KW - mitophagy

KW - neurodegeneration

KW - Parkinson's disease

U2 - 10.1016/j.molmed.2019.07.002

DO - 10.1016/j.molmed.2019.07.002

M3 - Review

C2 - 31375365

AN - SCOPUS:85069854565

VL - 26

SP - 8

EP - 20

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 1

ER -

ID: 226872065