Adipocytes are present at human and murine myotendinous junctions

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Adipocytes are present at human and murine myotendinous junctions. / Jakobsen, Jens R.; Jakobsen, Niels R.; Mackey, Abigail L.; Knudsen, Andreas B.; Hannibal, Jens; Koch, Manuel; Kjaer, Michael; Krogsgaard, Michael R.

In: Translational Sports Medicine, Vol. 4, No. 2, 2021, p. 223-230.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jakobsen, JR, Jakobsen, NR, Mackey, AL, Knudsen, AB, Hannibal, J, Koch, M, Kjaer, M & Krogsgaard, MR 2021, 'Adipocytes are present at human and murine myotendinous junctions', Translational Sports Medicine, vol. 4, no. 2, pp. 223-230. https://doi.org/10.1002/tsm2.212

APA

Jakobsen, J. R., Jakobsen, N. R., Mackey, A. L., Knudsen, A. B., Hannibal, J., Koch, M., Kjaer, M., & Krogsgaard, M. R. (2021). Adipocytes are present at human and murine myotendinous junctions. Translational Sports Medicine, 4(2), 223-230. https://doi.org/10.1002/tsm2.212

Vancouver

Jakobsen JR, Jakobsen NR, Mackey AL, Knudsen AB, Hannibal J, Koch M et al. Adipocytes are present at human and murine myotendinous junctions. Translational Sports Medicine. 2021;4(2):223-230. https://doi.org/10.1002/tsm2.212

Author

Jakobsen, Jens R. ; Jakobsen, Niels R. ; Mackey, Abigail L. ; Knudsen, Andreas B. ; Hannibal, Jens ; Koch, Manuel ; Kjaer, Michael ; Krogsgaard, Michael R. / Adipocytes are present at human and murine myotendinous junctions. In: Translational Sports Medicine. 2021 ; Vol. 4, No. 2. pp. 223-230.

Bibtex

@article{2f49b08eb8ab4eb5aa31136054867e61,
title = "Adipocytes are present at human and murine myotendinous junctions",
abstract = "The presence of adipocytes at the myotendinous junction (MTJ) has not previously been reported in mammals. However, during studies of the MTJ, our group has noticed the presence of adipocytes as a general and surprising phenomenon.The main aim of this study was to describe and quantify the presence of adipocytes in relation to the MTJ in healthy human subjects. In addition, we wanted to investigate whether adipocytes are also found at the MTJ in mice, which is a commonly used species in muscle and tendon research. Samples from the semitendinosus MTJ from 10 healthy human subjects and tibialis anterior and soleus from 6 mice were prepared for electron microscopy or for immunohistochemical labeling against perilipin (PLIN1, to identify adipocytes), collagen XXII (representing the myotendinous junction) and nuclei (DAPI).In all humans and mice, numerous adipocytes were present at the MTJ. Electron microscopy of human samples showed that adipocytes were located near the characteristic foldings of the muscle membrane at the MTJ.The large number of adipocytes at the MTJ in humans and mice suggests that they have an important function in the interplay between skeletal muscle and tendon in this region.",
author = "Jakobsen, {Jens R.} and Jakobsen, {Niels R.} and Mackey, {Abigail L.} and Knudsen, {Andreas B.} and Jens Hannibal and Manuel Koch and Michael Kjaer and Krogsgaard, {Michael R.}",
year = "2021",
doi = "10.1002/tsm2.212",
language = "English",
volume = "4",
pages = "223--230",
journal = "Translational Sports Medicine",
issn = "2573-8488",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Adipocytes are present at human and murine myotendinous junctions

AU - Jakobsen, Jens R.

AU - Jakobsen, Niels R.

AU - Mackey, Abigail L.

AU - Knudsen, Andreas B.

AU - Hannibal, Jens

AU - Koch, Manuel

AU - Kjaer, Michael

AU - Krogsgaard, Michael R.

PY - 2021

Y1 - 2021

N2 - The presence of adipocytes at the myotendinous junction (MTJ) has not previously been reported in mammals. However, during studies of the MTJ, our group has noticed the presence of adipocytes as a general and surprising phenomenon.The main aim of this study was to describe and quantify the presence of adipocytes in relation to the MTJ in healthy human subjects. In addition, we wanted to investigate whether adipocytes are also found at the MTJ in mice, which is a commonly used species in muscle and tendon research. Samples from the semitendinosus MTJ from 10 healthy human subjects and tibialis anterior and soleus from 6 mice were prepared for electron microscopy or for immunohistochemical labeling against perilipin (PLIN1, to identify adipocytes), collagen XXII (representing the myotendinous junction) and nuclei (DAPI).In all humans and mice, numerous adipocytes were present at the MTJ. Electron microscopy of human samples showed that adipocytes were located near the characteristic foldings of the muscle membrane at the MTJ.The large number of adipocytes at the MTJ in humans and mice suggests that they have an important function in the interplay between skeletal muscle and tendon in this region.

AB - The presence of adipocytes at the myotendinous junction (MTJ) has not previously been reported in mammals. However, during studies of the MTJ, our group has noticed the presence of adipocytes as a general and surprising phenomenon.The main aim of this study was to describe and quantify the presence of adipocytes in relation to the MTJ in healthy human subjects. In addition, we wanted to investigate whether adipocytes are also found at the MTJ in mice, which is a commonly used species in muscle and tendon research. Samples from the semitendinosus MTJ from 10 healthy human subjects and tibialis anterior and soleus from 6 mice were prepared for electron microscopy or for immunohistochemical labeling against perilipin (PLIN1, to identify adipocytes), collagen XXII (representing the myotendinous junction) and nuclei (DAPI).In all humans and mice, numerous adipocytes were present at the MTJ. Electron microscopy of human samples showed that adipocytes were located near the characteristic foldings of the muscle membrane at the MTJ.The large number of adipocytes at the MTJ in humans and mice suggests that they have an important function in the interplay between skeletal muscle and tendon in this region.

U2 - 10.1002/tsm2.212

DO - 10.1002/tsm2.212

M3 - Journal article

VL - 4

SP - 223

EP - 230

JO - Translational Sports Medicine

JF - Translational Sports Medicine

SN - 2573-8488

IS - 2

ER -

ID: 251836761