- 2020
- Published
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing
Macheret, M., Bhowmick, Rahul, Sobkowiak, K., Padayachy, L., Mailler, J., Hickson, Ian David & Halazonetis, T. D., 2020, In: Cell Research. 30, p. 997–1008Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heterotopic Ossification after an Achilles Tendon Rupture Cannot Be Prevented by Early Functional Rehabilitation: A Cohort Study
Magnusson, Stig Peter, Agergaard, A. S., Couppé, Christian, Svensson, R. B., Warming, S., Krogsgaard, Michael R., Kjær, Michael & Eliasson, P., 2020, In: Clinical Orthopaedics and Related Research. 478, 5, p. 1101-1108 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Møller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana, Blanca, Desler, Claus, Rasmussen, Lene Juel, Sustarsic, E. G., Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In: Frontiers in Immunology. 11, 22 p., 1968.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Desler, Claus, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In: iScience. 23, 10, 42 p., 101556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New methodologies in ageing research
Osborne, Brenna, Bakula, Daniela Janina, Ben Ezra, Michael, Dresen, C., Hartmann, E., Kristensen, S. M., Mkrtchyan, Garik, Nielsen, M. H., Petr, Michael Angelo & Scheibye-Knudsen, Morten, 2020, In: Ageing Research Reviews. 62, 11 p., 101094.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protecting the Aging Genome
Petr, Michael Angelo, Tulika, T., Carmona Marin, Lina Maria & Scheibye-Knudsen, Morten, 2020, In: Trends in Cell Biology. 30, 2, p. 117-132 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise
Søndenbroe, C., Bechshøft, C. J. L., Heisterberg, M. F., Jensen, S. M., Bomme, E., Schjerling, Peter, Karlsen, Anders, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2020, In: Cells. 9, 4, 893.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling
Tran, P. H. T., Malmgaard-Clausen, N. M., Puggaard, R. S., Svensson, R. B., Nybing, J. D., Hansen, P., Schjerling, P., Zinglersen, A. H., Couppé, Christian, Boesen, Mikael Ploug, Magnusson, Stig Peter & Kjær, Michael, 2020, In: FASEB Journal. 34, 1, p. 776-788 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
Venegas, A. B., Natsume, T., Kanemaki, M. & Hickson, Ian David, 2020, In: Cell Reports. 31, 3, 20 p., 107533.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No detectable remodelling in adult human menisci: an analysis based on the C14 bomb pulse
Våben, C., Heinemeier, K. M., Schjerling, P., Olsen, J., Petersen, Michael Mørk, Kjær, Michael & Krogsgaard, Michael R., 2020, In: British Journal of Sports Medicine. 54, 23, p. 1433-1437Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome
Wu, Wei, Bhowmick, Rahul, Vogel, Ivan, Özer, Ö., Ghisays, F., Thakur, R. S., Sanchez de Leon, E., Richter, P. H., Ren, L., Petrini, J. H., Hickson, Ian David & Liu, Ying, 2020, In: Nature Structural & Molecular Biology. 27, 5, p. 424-437 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells
Wu, Wei, Hickson, Ian David & Liu, Ying, 2020, In: Genome Instability & Disease. 1, 3, p. 114–128 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Ying, Hickson, Ian David, Shen, H. & Ying, S., 2020, In: Molecular Cell. 78, 4, p. 714-724.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts
Yeung, C. C., Schoof, E. M., Tamáš, M., Mackey, Abigail & Kjær, Michael, 2020, In: Cell Communication and Signaling. 18, 1, 15 p., 177.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of Tenocyte Populations from the Core and Periphery of Equine Tendons
Zhang, C., Svensson, R. B., Montagna, C., Carstensen, Helena, Buhl, Rikke, Schoof, E. M., Kjær, Michael, Magnusson, Stig Peter & Yeung, C. Y. C., 2020, In: Journal of Proteome Research. 19, 10, p. 4137-4144 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regional collagen turnover and composition of the human patellar tendon
Zhang, C., Couppé, Christian, Scheijen, J. L. J. M., Schalkwijk, C. G., Kjær, Michael, Magnusson, Stig Peter & Svensson, R. B., 2020, In: Journal of Applied Physiology. 128, 4, p. 884-891Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regional differences in turnover, composition, and mechanics of the porcine flexor tendon
Zhang, C., Svensson, R. B., Couppé, Christian, Schjerling, P., Skovgaard, D., Kjær, Michael & Magnusson, Stig Peter, 2020, In: Connective Tissue Research. 61, 5, p. 475-484Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial dysfunction induced by variation in the non-coding genome – A proposed workflow to improve diagnostics
du Mee, D. J. M., Bak, M., Østergaard, Elsebet & Rasmussen, Lene Juel, 2020, In: Mitochondrion. 53, p. 255-259Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Integrated method for quantitative morphometry and oxygen transport modeling in striated muscle
Al-Shammari, A. A., Kissane, R. W. P., Holbek, S., Mackey, Abigail, Andersen, T. R., Gaffney, E. A., Kjær, Michael & Egginton, S., 2019, In: Journal of Applied Physiology. 126, 3, p. 544-557 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A defined human aging phenome
Andreassen, Søren Norge, Ben Ezra, Michael & Scheibye-Knudsen, Morten, 2019, In: Aging. 11, 15, p. 5786-5806 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes
Baekkerud, F. H., Salerno, S., Ceriotti, P., Morland, C., Storm-Mathisen, J., Bergersen, L. H., Hoydal, M. A., Catalucci, D. & Stolen, T. O., 2019, In: Cardiovascular Toxicology. 19, 5, p. 422-431 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Latest advances in aging research and drug discovery
Bakula, D., Ablasser, A., Aguzzi, A., Antebi, A., Barzilai, N., Bittner, M. I., Jensen, M. B., Calkhoven, C. F., Chen, D., de Grey, A. D. N. J., Feige, J. N., Georgievskaya, A., Gladyshev, V. N., Golato, T., Gudkov, A. V., Hoppe, T., Kaeberlein, M., Katajisto, P., Kennedy, B. K., Lal, U. & 10 others, , 2019, In: Aging. 11, 22, p. 9971-9981 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copenhagen Consensus statement 2019: Physical activity and ageing
Bangsbo, J., Blackwell, J., Boraxbekk, C-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjær, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., Skinner, T. & 6 others, , 2019, In: British Journal of Sports Medicine. 53, 14, p. 856-858 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Behandling af akutte muskelskader
Bayer, M. L., Mackey, Abigail, Magnusson, Stig Peter, Krogsgaard, Michael R. & Kjær, Michael, 18 Feb 2019, In: Ugeskrift for Laeger. 181, 8, 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans
Bayer, M. L., Bang, L., Hoegberget-Kalisz, M., Svensson, R. B., Olesen, J. L., Karlsson, M. M., Schjerling, Peter, Hellsten, Ylva, Høier, B., Magnusson, Stig Peter & Kjær, Michael, 2019, In: F A S E B Journal. 33, 9, p. 10369-10382 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The influence of direct and indirect fibroblast cell contact on human myogenic cell behaviour and gene expression in vitro
Bechshøft, C. J. L., Schjerling, Peter, Kjær, Michael & Mackey, Abigail, 2019, In: Journal of Applied Physiology. 127, 2, p. 342-355Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and non-myogenic cells derived from human skeletal muscle
Bechshøft, C. J. L., Jensen, S. M., Schjerling, P., Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, Jun 2019, In: American Journal of Physiology: Cell Physiology. 316, 6, p. C898-C912Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICH and TOP3A cooperate to induce positive DNA supercoiling
Bizard, A. H., Allemand, J. F., Hassenkam, Tue, Paramasivam, M., Sarlós, K., Singh, Manika Indrajit & Hickson, Ian David, 2019, In: Nature Structural and Molecular Biology. 26, 4, p. 267-274 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Oral Contraceptive Use on Adaptations to Resistance Training
Dalgaard, L. B., Dalgas, U., Andersen, J. L., Rossen, N. B., Moller, A. B., Stodkilde-Jorgensen, H., Jorgensen, J. O., Kovanen, V., Couppe, C., Langberg, Henning, Kjær, Michael & Hansen, M., Jul 2019, In: Frontiers in Physiology. 10, 14 p., 824.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome
Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, G., Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, L. J., Greenblatt, M. S. & 2 others, , 2019, In: Genetics in Medicine. 21, p. 1486–1496Research output: Contribution to journal › Journal article › Research › peer-review
- Published
From powerhouse to perpetrator—mitochondria in health and disease
Fakouri, N. B., Hansen, T. L., Desler, Claus, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In: Biology. 8, 2, 15 p., 35.Research output: Contribution to journal › Review › Research › peer-review
- Published
Spontaneous astrocytic Ca2+ activity abounds in electrically suppressed ischemic penumbra of aged mice
Fordsmann, J. C., Murmu, R. P., Cai, Changsi, Brazhe, A., Thomsen, Kirsten Joan, Zambach, S. A., wbh615, wbh615, Lind, Barbara Lykke & Lauritzen, Martin, 2019, In: Glia. 67, 1, p. 37-52 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis
Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, L. H., 2019, In: Neurochemical Research. 44, 1, p. 22-37 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure
Hjerrild, J. N., Wobbe, A., Stausholm, M. B., Larsen, A. E., Josefsen, C. O., Malmgaard-Clausen, N. M., Dela, Flemming, Kjær, Michael, Magnusson, Stig Peter, Hansen, M., Svensson, R. B. & Couppé, C., 22 Jun 2019, In: Nutrients. 11, 6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain Responses to Passive Sensory Stimulation Correlate With Intelligence
Horwitz, A., Klemp, Marc Patrick Brag, Horwitz, Henrik, Thomsen, M. D., Rostrup, Egill, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin & Benedek, K., 2019, In: Frontiers in Aging Neuroscience. 11, 17 p., 201.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Corticosteroid injection is the best treatment in plantar fasciitis if combined with controlled training
Johannsen, F. E., Herzog, R. B., Malmgaard-Clausen, N. M., Hoegberget-Kalisz, M., Magnusson, Stig Peter & Kjær, Michael, 2019, In: Knee Surgery, Sports Traumatology, Arthroscopy. 27, 1, p. 5-12Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Esc2 promotes telomere stability in response to DNA replication stress
Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with resistance training in 83-94-year-old men and women
Karlsen, Anders, Bechshøft, R. L., Malmgaard-Clausen, N. M., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 3 Mar 2019, In: Acta Physiologica. 227, ja, e13271.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mitochondrial oxidative phosphorylation capacity of cryopreserved cells
Lauridsen, P. E., Rasmussen, Lene Juel & Desler, Claus, 2019, In: Mitochondrion. 47, p. 47-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers
Mamoshina, P., Kochetov, K., Cortese, F., Kovalchuk, A., Aliper, A., Putin, E., Scheibye-Knudsen, Morten, Cantor, C. R., Skjodt, N. M., Kovalchuk, O. & Zhavoronkov, A., 2019, In: Scientific Reports. 9, 10 p., 142.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lamin A/C promotes DNA base excision repair
Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD)
Medin, T., Jensen, V., Skare, O., Storm-Mathisen, J., Hvalby, O. & Bergersen, L. H., 2019, In: Behavioural Brain Research. 360, p. 209-215 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment
Medin, T., Medin, H., Hefte, M. B., Storm-Mathisen, J. & Bergersen, L. H., 2019, In: Behavioural Brain Research. 360, p. 279-285 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immobilization Decreases FOXO3a Phosphorylation and Increases Autophagy-Related Gene and Protein Expression in Human Skeletal Muscle
Møller, A. B., Vendelbo, M. H., Schjerling, Peter, Couppé, Christian, Møller, N., Kjær, Michael, Hansen, M. & Jessen, N., 14 Jun 2019, In: Frontiers in Physiology. 10, 14 p., 736.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MERTK Acts as a costimulatory receptor on human cd8 t cells
Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Desler, Claus & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular indicators of denervation in ageing human skeletal muscle
Soendenbroe, C., Heisterberg, M. F., Schjerling, Peter, Karlsen, Anders, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2019, In: Muscle & Nerve. 60, 4, p. 453-463 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosome instability syndromes
Taylor, A. M. R., Rothblum-Oviatt, C., Ellis, N. A., Hickson, Ian David, Meyer, S., Crawford, T. O., Smogorzewska, A., Pietrucha, B., Weemaes, C. & Stewart, G. S., 2019, In: Nature Reviews. Disease Primers. 5, 20 p., 64.Research output: Contribution to journal › Review › Research › peer-review
- Published
The influence of fibrillin‐1 and physical activity upon tendon tissue morphology and mechanical properties in mice
Tran, P. H. T., Skrba, T., Wondimu, E., Galatioto, G., Svensson, R. B., Olesen, A. T., Mackey, Abigail, Magnusson, Stig Peter, Ramirez, F. & Kjær, Michael, 1 Nov 2019, In: Physiological Reports. 7, 21, 9 p., e14267 .Research output: Contribution to journal › Journal article › Research › peer-review
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Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size
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