Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency

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Standard

Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency. / Bach, Mathias Jacobsen; Jakubauskaite, Audrone; Law, Ian; Henriksen, Otto Mølby; Havsteen, Inger; Henriksen, Alexander Cuculiza; Rosenbaum, Sverre; Marner, Lisbeth.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 33, No. 1, 107466, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bach, MJ, Jakubauskaite, A, Law, I, Henriksen, OM, Havsteen, I, Henriksen, AC, Rosenbaum, S & Marner, L 2024, 'Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency', Journal of Stroke and Cerebrovascular Diseases, vol. 33, no. 1, 107466. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107466

APA

Bach, M. J., Jakubauskaite, A., Law, I., Henriksen, O. M., Havsteen, I., Henriksen, A. C., Rosenbaum, S., & Marner, L. (2024). Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency. Journal of Stroke and Cerebrovascular Diseases, 33(1), [107466]. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107466

Vancouver

Bach MJ, Jakubauskaite A, Law I, Henriksen OM, Havsteen I, Henriksen AC et al. Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency. Journal of Stroke and Cerebrovascular Diseases. 2024;33(1). 107466. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107466

Author

Bach, Mathias Jacobsen ; Jakubauskaite, Audrone ; Law, Ian ; Henriksen, Otto Mølby ; Havsteen, Inger ; Henriksen, Alexander Cuculiza ; Rosenbaum, Sverre ; Marner, Lisbeth. / Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency. In: Journal of Stroke and Cerebrovascular Diseases. 2024 ; Vol. 33, No. 1.

Bibtex

@article{7ba7c791029949459b4122f4573322b6,
title = "Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency",
abstract = "Objectives: Quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET with arterial cannulation and acetazolamide (ACZ) challenge have been reserved to identify high-risk patients that are candidates for by-pass operation. We aimed to assess the prognostic value of various parameters in quantitative [15O]H2O PET measurements in patients not subsequently undergoing surgery. Methods: We identified 32 eligible patients who underwent [15O]H2O brain PET imaging for suspicion of hemodynamic insufficiency between 2009 and 2020. Cerebrovascular events were defined as new ischemic lesions on MRI, stroke, transient ischemic attack, vascular dementia. Follow-up period was 91 months (range: 26-146). rCBF before (rCBFbase) and after (rCBFacz) ACZ challenge and the relative increase (CVR), were examined in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territories of the affected hemisphere, and the most recent MRI scans were scored for infarcts and white matter lesions. Results: Receiver operating characteristic (ROC) curve analysis showed higher prognostic accuracy for rCBFacz(AUC:0.82) compared to CVR (AUC:0.72) and rCBFbase (AUC:0.77). ROC AUC, optimal thresholds (and corresponding sensitivity/specificity/accuracy) for rCBFacz after ACZ in individual territories were 0.79 and 37.8 mL 100g−1 min−1 (0.81/0.63/0.72) for the ACA, 0.84 and 32 mL 100g−1 min−1 (0.81/0.75/0.78) for the MCA, and 0.70 and 43.9 ml/(mL 100g−1 min−1 (0.81/0.43/0,62) for the PCA. Kaplan Meier survival curve showed longer event-free survival in patients with rCBFacz below cut-off (p=0.007). In multivariate analysis rCBFacz remained a significant predictor when correcting for age. Conclusion: Quantitative rCBF measurements after ACZ challenge with [15O]H2O PET provided high prognostic value for future cerebrovascular events.",
keywords = "Acetazolamide, Cerebral blood flow, Cerebrovascular disease, Hypoperfusion, Vascular reactivity",
author = "Bach, {Mathias Jacobsen} and Audrone Jakubauskaite and Ian Law and Henriksen, {Otto M{\o}lby} and Inger Havsteen and Henriksen, {Alexander Cuculiza} and Sverre Rosenbaum and Lisbeth Marner",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2024",
doi = "10.1016/j.jstrokecerebrovasdis.2023.107466",
language = "English",
volume = "33",
journal = "Journal of Stroke & Cerebrovascular Diseases",
issn = "1052-3057",
publisher = "W.B.Saunders Co.",
number = "1",

}

RIS

TY - JOUR

T1 - Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency

AU - Bach, Mathias Jacobsen

AU - Jakubauskaite, Audrone

AU - Law, Ian

AU - Henriksen, Otto Mølby

AU - Havsteen, Inger

AU - Henriksen, Alexander Cuculiza

AU - Rosenbaum, Sverre

AU - Marner, Lisbeth

N1 - Publisher Copyright: © 2023

PY - 2024

Y1 - 2024

N2 - Objectives: Quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET with arterial cannulation and acetazolamide (ACZ) challenge have been reserved to identify high-risk patients that are candidates for by-pass operation. We aimed to assess the prognostic value of various parameters in quantitative [15O]H2O PET measurements in patients not subsequently undergoing surgery. Methods: We identified 32 eligible patients who underwent [15O]H2O brain PET imaging for suspicion of hemodynamic insufficiency between 2009 and 2020. Cerebrovascular events were defined as new ischemic lesions on MRI, stroke, transient ischemic attack, vascular dementia. Follow-up period was 91 months (range: 26-146). rCBF before (rCBFbase) and after (rCBFacz) ACZ challenge and the relative increase (CVR), were examined in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territories of the affected hemisphere, and the most recent MRI scans were scored for infarcts and white matter lesions. Results: Receiver operating characteristic (ROC) curve analysis showed higher prognostic accuracy for rCBFacz(AUC:0.82) compared to CVR (AUC:0.72) and rCBFbase (AUC:0.77). ROC AUC, optimal thresholds (and corresponding sensitivity/specificity/accuracy) for rCBFacz after ACZ in individual territories were 0.79 and 37.8 mL 100g−1 min−1 (0.81/0.63/0.72) for the ACA, 0.84 and 32 mL 100g−1 min−1 (0.81/0.75/0.78) for the MCA, and 0.70 and 43.9 ml/(mL 100g−1 min−1 (0.81/0.43/0,62) for the PCA. Kaplan Meier survival curve showed longer event-free survival in patients with rCBFacz below cut-off (p=0.007). In multivariate analysis rCBFacz remained a significant predictor when correcting for age. Conclusion: Quantitative rCBF measurements after ACZ challenge with [15O]H2O PET provided high prognostic value for future cerebrovascular events.

AB - Objectives: Quantitative regional cerebral perfusion (rCBF) measurements using [15O]H2O PET with arterial cannulation and acetazolamide (ACZ) challenge have been reserved to identify high-risk patients that are candidates for by-pass operation. We aimed to assess the prognostic value of various parameters in quantitative [15O]H2O PET measurements in patients not subsequently undergoing surgery. Methods: We identified 32 eligible patients who underwent [15O]H2O brain PET imaging for suspicion of hemodynamic insufficiency between 2009 and 2020. Cerebrovascular events were defined as new ischemic lesions on MRI, stroke, transient ischemic attack, vascular dementia. Follow-up period was 91 months (range: 26-146). rCBF before (rCBFbase) and after (rCBFacz) ACZ challenge and the relative increase (CVR), were examined in the anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territories of the affected hemisphere, and the most recent MRI scans were scored for infarcts and white matter lesions. Results: Receiver operating characteristic (ROC) curve analysis showed higher prognostic accuracy for rCBFacz(AUC:0.82) compared to CVR (AUC:0.72) and rCBFbase (AUC:0.77). ROC AUC, optimal thresholds (and corresponding sensitivity/specificity/accuracy) for rCBFacz after ACZ in individual territories were 0.79 and 37.8 mL 100g−1 min−1 (0.81/0.63/0.72) for the ACA, 0.84 and 32 mL 100g−1 min−1 (0.81/0.75/0.78) for the MCA, and 0.70 and 43.9 ml/(mL 100g−1 min−1 (0.81/0.43/0,62) for the PCA. Kaplan Meier survival curve showed longer event-free survival in patients with rCBFacz below cut-off (p=0.007). In multivariate analysis rCBFacz remained a significant predictor when correcting for age. Conclusion: Quantitative rCBF measurements after ACZ challenge with [15O]H2O PET provided high prognostic value for future cerebrovascular events.

KW - Acetazolamide

KW - Cerebral blood flow

KW - Cerebrovascular disease

KW - Hypoperfusion

KW - Vascular reactivity

U2 - 10.1016/j.jstrokecerebrovasdis.2023.107466

DO - 10.1016/j.jstrokecerebrovasdis.2023.107466

M3 - Journal article

C2 - 38029459

AN - SCOPUS:85178171383

VL - 33

JO - Journal of Stroke & Cerebrovascular Diseases

JF - Journal of Stroke & Cerebrovascular Diseases

SN - 1052-3057

IS - 1

M1 - 107466

ER -

ID: 381066492