TY - JOUR

T1 - Associations Between Attention Deficit Hyperactivity Disorder Symptom Dimensions and Disordered Eating Symptoms in Adolescence

T2 - A Population-Based Twin Study

AU - Yilmaz, Zeynep

AU - Quattlebaum, Mary J.

AU - Pawar, Pratiksha S.

AU - Thornton, Laura M.

AU - Bulik, Cynthia M.

AU - Javaras, Kristin N.

AU - Yao, Shuyang

AU - Lichtenstein, Paul

AU - Larsson, Henrik

AU - Baker, Jessica H.

N1 - Funding Information: TCHAD study was supported by the Swedish Research Council for Health, Working Life and Welfare (2004-0383) and the Swedish Research Council (2004-1415). ZY acknowledges support from the National Institute of Mental Health (NIMH; T32MH076694, K01MH109782, R01MH120170) and Brain and Behavior Research Foundation NARSAD Young Investigator Award (Grant # 28799). MJQ was supported by the National Institute of General Medical Sciences (T32GM081740). CMB acknowledges grant support from the Swedish Research Council (Vetenskapsrådet, award: 538-2013-8864) and the Lundbeck Foundation (Grant # R276-2018-4581). KNJ was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (K23DK120517). JHB received grant funding from the NIMH (K01MH106675). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2023

Y1 - 2023

N2 - Although bivariate associations between attention-deficit/hyperactivity disorder (ADHD) and eating disorders in adolescent girls and boys have been previously identified, the mechanistic link underlying the symptom-level associations remains unclear. We evaluated shared genetic and environmental influences on ADHD symptoms and disordered eating in 819 female and 756 male twins from the Swedish TCHAD cohort using bivariate models. Common additive genetic and unique environmental effects accounted for majority of ADHD and disordered eating associations in a differential manner. For girls, the strongest genetic correlation was observed for cognitive/inattention problems-bulimia (0.54), with genetic factors accounting for 67% of the phenotypic correlation. For boys, the strongest genetic correlations were observed for conduct problems-bulimia and hyperactivity-bulimia (~ 0.54), accounting for 83% and 95% of the phenotypic correlation, respectively. As per our findings, the risk of comorbidity and shared genetics highlights the need for preventative measures and specialized treatment for ADHD and disordered eating in both sexes.

AB - Although bivariate associations between attention-deficit/hyperactivity disorder (ADHD) and eating disorders in adolescent girls and boys have been previously identified, the mechanistic link underlying the symptom-level associations remains unclear. We evaluated shared genetic and environmental influences on ADHD symptoms and disordered eating in 819 female and 756 male twins from the Swedish TCHAD cohort using bivariate models. Common additive genetic and unique environmental effects accounted for majority of ADHD and disordered eating associations in a differential manner. For girls, the strongest genetic correlation was observed for cognitive/inattention problems-bulimia (0.54), with genetic factors accounting for 67% of the phenotypic correlation. For boys, the strongest genetic correlations were observed for conduct problems-bulimia and hyperactivity-bulimia (~ 0.54), accounting for 83% and 95% of the phenotypic correlation, respectively. As per our findings, the risk of comorbidity and shared genetics highlights the need for preventative measures and specialized treatment for ADHD and disordered eating in both sexes.

KW - Attention-deficit/hyperactivity disorder

KW - Disordered eating

KW - Genetics

KW - Population cohort

KW - Sex differences

KW - Symptom-level associations

KW - Twin study

U2 - 10.1007/s10519-022-10128-5

DO - 10.1007/s10519-022-10128-5

M3 - Journal article

C2 - 36484893

AN - SCOPUS:85143604736

VL - 53

SP - 143

EP - 153

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 2

ER -