Roles of NAD+ in Health and Aging

Center for Healthy Aging

Roles of NAD⁺ in Health and Aging

Research output: Contribution to journal › Journal article › Research › peer-review

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Roles of NAD⁺ in Health and Aging. / Lautrup, Sofie; Hou, Yujun; Fang, Evandro F.; Bohr, Vilhelm A.

In: Cold Spring Harbor Perspectives in Medicine, Vol. 14, No. 1, a041193, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lautrup, S, Hou, Y, Fang, EF & Bohr, VA 2024, 'Roles of NAD⁺ in Health and Aging', Cold Spring Harbor Perspectives in Medicine, vol. 14, no. 1, a041193. https://doi.org/10.1101/cshperspect.a041193

APA

Lautrup, S., Hou, Y., Fang, E. F., & Bohr, V. A. (2024). Roles of NAD⁺ in Health and Aging. Cold Spring Harbor Perspectives in Medicine, 14(1), [a041193]. https://doi.org/10.1101/cshperspect.a041193

Vancouver

Lautrup S, Hou Y, Fang EF, Bohr VA. Roles of NAD⁺ in Health and Aging. Cold Spring Harbor Perspectives in Medicine. 2024;14(1). a041193. https://doi.org/10.1101/cshperspect.a041193

Author

Lautrup, Sofie ; Hou, Yujun ; Fang, Evandro F. ; Bohr, Vilhelm A. / Roles of NAD⁺ in Health and Aging. In: Cold Spring Harbor Perspectives in Medicine. 2024 ; Vol. 14, No. 1.

Bibtex

@article{03a7bde8b6844a73bfe90876cebe9e0b,

title = "Roles of NAD+ in Health and Aging",

abstract = "NAD+, the essential metabolite involved in multiple reactions such as the regulation of cellular metabolism, energy production, DNA repair, mitophagy and autophagy, inflamma-tion, and neuronal function, has been the subject of intense research in the field of aging and disease over the last decade. NAD+ levels decline with aging and in some age-related dis-eases, and reduction in NAD+ affects all the hallmarks of aging. Here, we present an overview of the discovery of NAD+, the cellular pathways of producing and consuming NAD+, and discuss how imbalances in the production rate and cellular request of NAD+ likely contribute to aging and age-related diseases including neurodegeneration. Preclinical studies have revealed great potential for NAD+ precursors in promotion of healthy aging and improvement of neurodegeneration. This has led to the initiation of several clinical trials with NAD+ precursors to treat accelerated aging, age-associated dysfunctions, and diseases including Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s. NAD supplementation has great future potential clinically, and these studies will also provide insight into the mechanisms of aging.",

author = "Sofie Lautrup and Yujun Hou and Fang, {Evandro F.} and Bohr, {Vilhelm A.}",

year = "2024",

doi = "10.1101/cshperspect.a041193",

language = "English",

volume = "14",

journal = "Cold Spring Harbor Perspectives in Medicine",

issn = "2157-1422",

publisher = "Cold Spring Harbor Laboratory Press",

number = "1",

}

RIS

TY - JOUR

T1 - Roles of NAD+ in Health and Aging

AU - Lautrup, Sofie

AU - Hou, Yujun

AU - Fang, Evandro F.

AU - Bohr, Vilhelm A.

PY - 2024

Y1 - 2024

N2 - NAD+, the essential metabolite involved in multiple reactions such as the regulation of cellular metabolism, energy production, DNA repair, mitophagy and autophagy, inflamma-tion, and neuronal function, has been the subject of intense research in the field of aging and disease over the last decade. NAD+ levels decline with aging and in some age-related dis-eases, and reduction in NAD+ affects all the hallmarks of aging. Here, we present an overview of the discovery of NAD+, the cellular pathways of producing and consuming NAD+, and discuss how imbalances in the production rate and cellular request of NAD+ likely contribute to aging and age-related diseases including neurodegeneration. Preclinical studies have revealed great potential for NAD+ precursors in promotion of healthy aging and improvement of neurodegeneration. This has led to the initiation of several clinical trials with NAD+ precursors to treat accelerated aging, age-associated dysfunctions, and diseases including Alzheimer’s and Parkinson’s. NAD supplementation has great future potential clinically, and these studies will also provide insight into the mechanisms of aging.

AB - NAD+, the essential metabolite involved in multiple reactions such as the regulation of cellular metabolism, energy production, DNA repair, mitophagy and autophagy, inflamma-tion, and neuronal function, has been the subject of intense research in the field of aging and disease over the last decade. NAD+ levels decline with aging and in some age-related dis-eases, and reduction in NAD+ affects all the hallmarks of aging. Here, we present an overview of the discovery of NAD+, the cellular pathways of producing and consuming NAD+, and discuss how imbalances in the production rate and cellular request of NAD+ likely contribute to aging and age-related diseases including neurodegeneration. Preclinical studies have revealed great potential for NAD+ precursors in promotion of healthy aging and improvement of neurodegeneration. This has led to the initiation of several clinical trials with NAD+ precursors to treat accelerated aging, age-associated dysfunctions, and diseases including Alzheimer’s and Parkinson’s. NAD supplementation has great future potential clinically, and these studies will also provide insight into the mechanisms of aging.

U2 - 10.1101/cshperspect.a041193

DO - 10.1101/cshperspect.a041193

M3 - Journal article

C2 - 37848251

AN - SCOPUS:85181587704

VL - 14

JO - Cold Spring Harbor Perspectives in Medicine

JF - Cold Spring Harbor Perspectives in Medicine

SN - 2157-1422

IS - 1

M1 - a041193

ER -

ID: 380149837