Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function

Research output: Contribution to journal › Review › Research › peer-review

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Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function. / Madsen, Helena B.; Peeters, Marlies JW; Straten, Per thor; Desler, Claus.

In: Current Opinion in Biotechnology, Vol. 84, 103008, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Madsen, HB, Peeters, MJW, Straten, PT & Desler, C 2023, 'Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function', Current Opinion in Biotechnology, vol. 84, 103008. https://doi.org/10.1016/j.copbio.2023.103008

APA

Madsen, H. B., Peeters, M. JW., Straten, P. T., & Desler, C. (2023). Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function. Current Opinion in Biotechnology, 84, [103008]. https://doi.org/10.1016/j.copbio.2023.103008

Vancouver

Madsen HB, Peeters MJW, Straten PT, Desler C. Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function. Current Opinion in Biotechnology. 2023;84. 103008. https://doi.org/10.1016/j.copbio.2023.103008

Author

Madsen, Helena B. ; Peeters, Marlies JW ; Straten, Per thor ; Desler, Claus. / Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function. In: Current Opinion in Biotechnology. 2023 ; Vol. 84.

Bibtex

@article{a56c87162b6c4de386bf5d8e7ab1005a,

title = "Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function",

abstract = "Nucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune function and tumor cell survival. ATP stimulates antitumor immunity by activating purinergic receptors, while adenosine acts as a potent immunosuppressor. Targeting nucleotide metabolism in the TME holds immense promise for cancer therapy. Understanding the intricate relationship between nucleotide metabolism, the TME, and immune responses will pave the way for innovative therapeutic interventions.",

author = "Madsen, {Helena B.} and Peeters, {Marlies JW} and Straten, {Per thor} and Claus Desler",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

doi = "10.1016/j.copbio.2023.103008",

language = "English",

volume = "84",

journal = "Current Opinion in Biotechnology",

issn = "0958-1669",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function

AU - Madsen, Helena B.

AU - Peeters, Marlies JW

AU - Straten, Per thor

AU - Desler, Claus

PY - 2023

Y1 - 2023

N2 - Nucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune function and tumor cell survival. ATP stimulates antitumor immunity by activating purinergic receptors, while adenosine acts as a potent immunosuppressor. Targeting nucleotide metabolism in the TME holds immense promise for cancer therapy. Understanding the intricate relationship between nucleotide metabolism, the TME, and immune responses will pave the way for innovative therapeutic interventions.

AB - Nucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune function and tumor cell survival. ATP stimulates antitumor immunity by activating purinergic receptors, while adenosine acts as a potent immunosuppressor. Targeting nucleotide metabolism in the TME holds immense promise for cancer therapy. Understanding the intricate relationship between nucleotide metabolism, the TME, and immune responses will pave the way for innovative therapeutic interventions.

U2 - 10.1016/j.copbio.2023.103008

DO - 10.1016/j.copbio.2023.103008

M3 - Review

C2 - 37863018

AN - SCOPUS:85174193778

VL - 84

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

M1 - 103008

ER -

ID: 373466782

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