- 2015
- Published
Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes
Akintola, A. A., van den Berg, A., Altmann-Schneider, I., Jansen, S. W., van Buchem, M. A., Slagboom, P. E., Westendorp, Rudi GJ, van Heemst, D. & van der Grond, J., Aug 2015, In: Age (Omaha). 37, p. 1-12 12 p., 74.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of DNA base excision repair in brain homeostasis and disease
Akbari, M., Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In: DNA Repair. 32, p. 172-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions
Jansen, S. W., Roelfsema, F., Akintola, A. A., Oei, N. Y., Cobbaert, C. M., Ballieux, B. E., van der Grond, J., Westendorp, Rudi GJ, Pijl, H. & van Heemst, D., 20 Jul 2015, In: PLOS ONE. 10, 7, p. 1-15 15 p., e0133119.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional adaptation of the human β-cells after frequent exposure to noradrenaline
Dela, Flemming, Jul 2015, In: The Journal of Physiology. 593, 14, p. 3199-206 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intrinsic and extrinsic mortality reunited
Koopman, J. J. E., Wensink, M. J., Rozing, M. P., van Bodegom, D. & Westendorp, Rudi GJ, Jul 2015, In: Experimental Gerontology. 67, p. 48-53 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study
Sabayan, B., van der Grond, J., Westendorp, Rudi GJ, van Buchem, M. A. & de Craen, A. J. M., Jun 2015, In: Neurobiology of Aging. 36, 6, p. 2130–2135 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comment on Režen et al. Expression changes in human skeletal muscle miRNAs following 10 days of bed rest in young healthy males.
Kristensen, M. M., Helge, Jørn Wulff & Dela, Flemming, Jun 2015, In: Acta Physiologica (Print). 214, 2, p. 157 1 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Comment on chondronikola et Al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes 2014;63:4089-4099
Dela, Flemming & Helge, Jørn Wulff, Jun 2015, In: Diabetes. 64, 6, p. e12-3 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Six weeks' aerobic retraining after two weeks' immobilization restores leg lean mass and aerobic capacity but does not fully rehabilitate leg strenght in young and older men
Vigelsø Hansen, A., Gram, M., Wiuff, C., L. Andersen, J., Helge, Jørn Wulff & Dela, Flemming, Jun 2015, In: Journal of Rehabilitation Medicine. 47, 6, p. 552-560 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis
Chaker, L., Baumgartner, C., den Elzen, W. P. J., Ikram, M. A., Blum, M. R., Collet, T-H., Bakker, S. J. L., Dehghan, A., Drechsler, C., Luben, R. N., Hofman, A., Portegies, M. L. P., Medici, M., Iervasi, G., Stott, D. J., Ford, I., Bremner, A., Wanner, C., Ferrucci, L., Newman, A. B. & 19 others, , Jun 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 6, p. 2181-2191 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Thyroid Function Within the Normal Range and Risk of Coronary Heart Disease: An Individual Participant Data Analysis of 14 Cohorts
Åsvold, B. O., Vatten, L. J., Bjøro, T., Bauer, D. C., Bremner, A., Cappola, A. R., Ceresini, G., den Elzen, W. P. J., Ferrucci, L., Franco, O. H., Franklyn, J. A., Gussekloo, J., Iervasi, G., Imaizumi, M., Kearney, P. M., Khaw, K-T., Maciel, R. M. B., Newman, A. B., Peeters, R. P., Psaty, B. M. & 10 others, , Jun 2015, In: J A M A Internal Medicine. 175, 6, p. 1037-47 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
Akintola, A. A., van den Berg, A., van Buchem, M. A., Jansen, S. W., Slagboom, E. P., Westendorp, Rudi GJ, van der Grond, J. & van Heemst, D., 28 May 2015, In: Frontiers in Aging Neuroscience. 7, p. 1-9 9 p., 92.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis
Blum, M. R., Bauer, D. C., Collet, T-H., Fink, H. A., Cappola, A. R., da Costa, B. R., Wirth, C. D., Peeters, R. P., Åsvold, B. O., den Elzen, W. P. J., Luben, R. N., Imaizumi, M., Bremner, A. P., Gogakos, A., Eastell, R., Kearney, P. M., Strotmeyer, E. S., Wallace, E. R., Hoff, M., Ceresini, G. & 14 others, , 26 May 2015, In: J A M A: The Journal of the American Medical Association. 313, 20, p. 2055-65 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heart rate variability, but not heart rate, is associated with handgrip strength and mortality in older Africans at very low cardiovascular risk: A population-based study
Koopman, J. J. E., van Bodegom, D., Maan, A. C., Li, Z., Ziem, J. B., Westendorp, Rudi GJ & Jukema, J. W., May 2015, In: International Journal of Cardiology. 187, p. 559-561 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Preoperative β-cell function in patients with type 2 diabetes is important for the outcome of Roux-en-Y gastric bypass surgery
Lund, M. T., Hansen, M., Skaaby, Stinna, Dalby, S., Støckel, M., Floyd, A. K., Bech, K., Helge, Jørn Wulff, Holst, Jens Juul & Dela, Flemming, 13 Apr 2015, In: The Journal of Physiology. 593, 14, p. 3123-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial
Nordby, P., Rosenkilde, M., Ploug, Thorkil, Westh, K., Feigh, M., Nielsen, N. B., Helge, Jørn Wulff & Stallknecht, Bente Merete, 1 Apr 2015, In: Journal of Applied Physiology. 118, 7, p. 803-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation
Ziegler, A. K., Grand, J., Stangerup, I., Nielsen, H. J., Dela, Flemming, Magnussen, K. & Helge, Jørn Wulff, Apr 2015, In: Transfusion. 55, 4, p. 898–905 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An in vivo study on brain microstructure in biological and chronological ageing
Altmann-Schneider, I., de Craen, A. J. M., van den Berg-Huysmans, A. A., Slagboom, P., Westendorp, Rudi GJ, van Buchem, M. A. & van der Grond, J., 25 Mar 2015, In: PloS one. 10, 3, p. 1-12 12 p., e0120778.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The challenges of human population ageing
Sander, M., Oxlund, Bjarke, Jespersen, Astrid Pernille, Krasnik, Allan, Mortensen, Erik Lykke, Westendorp, Rudi GJ & Rasmussen, Lene Juel, Mar 2015, In: Age and Ageing. 44, 2, p. 185-7 3 p.Research output: Contribution to journal › Journal article › Communication
- Published
The psychological profile of bariatric patients with and without type 2 diabetes: baseline results of the longitudinal GASMITO-PSYC study
Wimmelmann, Cathrine Lawaetz, Smith, E., Lund, M. T., Hansen, M., Dela, Flemming & Mortensen, Erik Lykke, Mar 2015, In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 11, 2, p. 412-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles
Christiansen, L. B., Dela, Flemming, Koch, Jørgen & Yokota, T., 11 Feb 2015, In: Journal of Veterinary Medical Science. 77, 6, p. 669-675 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue
Larsen, Steen, Danielsen, J. H., Søndergård, S. D., Søgaard, D., Vigelsoe, A., Dybboe, R., Skaaby, Stinna, Dela, Flemming & Helge, Jørn Wulff, Feb 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, 1, p. e59-e69Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of metformin on glucose homeostasis during moderate exercise
Hansen, M., Palsøe, M. K., Helge, Jørn Wulff & Dela, Flemming, Feb 2015, In: Diabetes Care. 38, 2, p. 293-301 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., Holmes, M. V., Engmann, J. E. L., Shah, T., Sofat, R., Stender, S., Johnson, P. C. D., Scott, R. A., Leusink, M., Verweij, N., Sharp, S. J., Guo, Y., Giambartolomei, C., Chung, C., Peasey, A., Amuzu, A., Li, K., Palmen, J. & 113 others, , 24 Jan 2015, In: Lancet. 385, 9965, p. 351-361 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance
Maynard, S., Keijzers, G., Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In: Acta Physiologica (Print). 213, 1, p. 156-170 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization
Dahl, R., Larsen, S., Dohlmann, T. L., Qvortrup, Klaus, Helge, Jørn Wulff, Dela, Flemming & Prats Gavalda, Clara, Jan 2015, In: Acta Physiologica. 213, 1, p. 145-155Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study: role of functional and cognitive status
Ogliari, G., Westendorp, Rudi GJ, Muller, M., Mari, D., Torresani, E., Felicetta, I., Lucchi, T., Rossi, P. D., Sabayan, B. & de Craen, A. J. M., 2015, In: Age and Ageing. 44, 6, p. 932-937 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Central and peripheral hemodynamics in exercising humans: leg vs arm exercise
Calbet, J. A. L., González-Alonso, J., Helge, Jørn Wulff, Søndergaard, H., Munch-Andersen, T., Saltin, B. & Boushel, R., 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 144-157Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males
Guadalupe-Grau, A., Plenge, U., Helbo, S., Kristensen, M., Andersen, P. R., Fago, A., Belhage, B., Dela, Flemming & Helge, Jørn Wulff, 2015, In: Journal of Sports Sciences. 33, 6, p. 570-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner
Baranowski, M., Błachnio-Zabielska, A. U., Charmas, M., Helge, Jørn Wulff, Dela, Flemming, Książek, M., Długołęcka, B., Klusiewicz, A., Chabowski, A. & Górski, J., 2015, In: European Journal of Applied Physiology. 115, 5, p. 993-1003 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle
Vigelsø Hansen, A., Dybboe, R., Hansen, C. N., Dela, Flemming, Helge, Jørn Wulff & Guadalupe Grau, A., 2015, In: Journal of Applied Physiology. 118, 3, p. 386-394 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures
Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In: Bioscience Reports. 35, 3, 13 p., e00206.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism
Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., Slagboom, P. E., van der Grond, J., Demeneix, B. A., Pijl, H., Westendorp, Rudi GJ & van Heemst, D., 2015, In: Scientific Reports. 5, 11 p., 11525 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy
Christiansen, L. B., Dela, Flemming, Koch, Jørgen, Hansen, C. N., Leifsson, Páll S. & Yokota, T., 2015, In: American Journal of Physiology: Heart and Circulatory Physiology. 308, 10, p. H1237-H1247 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inability to match energy intake with energy expenditure at sustained near-maximal rates of energy expenditure in older men during a 14-d cycling expedition
Rosenkilde Larsen, M., Morville, T., Riis Andersen, P., Kjær, K., Rasmusen, H., Holst, Jens Juul, Dela, Flemming, Westerterp, K., Sjödin, Anders Mikael & Helge, Jørn Wulff, 2015, In: American Journal of Clinical Nutrition. 102, 6, p. 1398-1405 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin-induced hyperglycemia
Larsen, Steen, Scheede-Bergdahl, C., Whitesell, T., Boushel, R. & Bergdahl, A., 2015, In: Physiological Reports. 3, 7, p. 1-10 10 p., e12467.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LDL cholesterol still a problem in old age? A Mendelian randomization study
Postmus, I., Deelen, J., Sedaghat, S., Trompet, S., de Craen, A. J., Heijmans, B. T., Franco, O. H., Hofman, A., Dehghan, A., Slagboom, P. E., Westendorp, Rudi GJ & Jukema, J. W., 2015, In: International Journal of Epidemiology. 44, 2, p. 604-612 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Listening to the voices of abused older people: should we classify system abuse?
Mysyuk, Y., Westendorp, Rudi GJ, Biggs, S. & Lindenberg, J., 2015, In: B M J (Online). 350, h2697.Research output: Contribution to journal › Journal article › Communication
- Published
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter
Gnaiger, E., Boushel, R., Søndergaard, H., Munch-Andersen, T., Damsgaard, R., Hagen, C., Díez-Sánchez, C., Ara, I., Wright-Paradis, C., Schrauwen, P., Hesselink, M., Calbet, J. A. L., Christiansen, M., Helge, Jørn Wulff & Saltin, B., 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Suppl 4, p. 126-34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of performance in Vasaloppet through long lasting ski- ergometer and rollerski tests in cross-country skiers
Mygind, Erik, Wulff, K., Jensen, M. R. & Helge, Jørn Wulff, 2015, In: International Journal of Sports and Exercise Medicine. 1, 5, 7 p., 025.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
White matter lesion progression: genome-wide search for genetic influences
Hofer, E., Cavalieri, M., Bis, J. C., DeCarli, C., Fornage, M., Sigurdsson, S., Srikanth, V., Trompet, S., Verhaaren, B. F. J., Wolf, C., Yang, Q., Adams, H. H. H., Amouyel, P., Beiser, A., Buckley, B. M., Callisaya, M., Chauhan, G., de Craen, A. J. M., Dufouil, C., van Duijn, C. M. & 40 others, , 2015, In: Stroke. 46, p. 3048-3057 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
A maximal cycle test with good validity and high repeatability in adults of all ages
Eriksen, L., Tolstrup, J. S., Larsen, Steen, Grønbæk, M. & Helge, Jørn Wulff, Dec 2014, In: International Journal of Sports Medicine. 35, 14, p. 1184-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome
Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, L. H., Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L. & 2 others, , 4 Nov 2014, In: Cell Metabolism. 20, 5, p. 840-855 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX
Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, G., Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Carcinogenesis. 35, 11, p. 2415-2424 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of RecQ helicases in non-homologous end-joining
Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Impaired mitochondrial oxidative phosphorylation and fatty acid oxidation with enhanced mitochondrial oxidative stress in spontaneously-occurring feline hypertrophic cardiomyopathy
Yokota, T., Christiansen, L. B. & Dela, Flemming, Oct 2014, In: Journal of Cardiac Failure. 20, 10 supplement, p. S147 1 p., O-008.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Two weeks of one-leg immobilization decreases skeletal muscle respiratory capacity equally in young and elderly men
Gram, M., Vigelsø Hansen, A., Yokota, T., Hansen, C. N., Helge, Jørn Wulff, Hey-Mogensen, M. & Dela, Flemming, Oct 2014, In: Experimental Gerontology. 58, p. 269-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of exercise training on mitochondrial function in patients with type 2 diabetes
Larsen, Steen, Skaaby, Stinna, Helge, Jørn Wulff & Dela, Flemming, 15 Aug 2014, In: World Journal of Diabetes. 5, 4, p. 482-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.
Vigelsø Hansen, A., Andersen, N. B. & Dela, Flemming, 12 Jul 2014, In: International Journal of Physiology, Pathophysiology and Pharmacology. 6, 2, p. 84-101 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
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