Individualized Health

  1. 2016
  2. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In: Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study

    Koopman, J. J. E., Pijpe, J., Böhringer, S., van Bodegom, D., Eriksson, U. K., Sanchez-Faddeev, H., Ziem, J. B., Zwaan, B., Slagboom, P. E., de Knijff, P. & Westendorp, Rudi GJ, 27 Jun 2016, In: Aging. 8, 7, p. 1364-1383 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    An Emerging Epidemic of Noncommunicable Diseases in Developing Populations Due to a Triple Evolutionary Mismatch

    Koopman, J. J. E., van Bodegom, D., Ziem, J. B. & Westendorp, Rudi GJ, Jun 2016, In: American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1189-1192 4 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  6. Published

    The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes

    Hansen, M., Lund, M. T., Jørgensen, A. L. K., Palsøe, M. K., van Hall, Gerrit, Helge, Jørn Wulff & Dela, Flemming, Jun 2016, In: Acta Diabetologica. 53, 3, p. 423–432 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Aerobic Exercise Training Increases Muscle Water Content in Obese Middle-Age Men

    Mora-Rodríguez, R., Sanchez-Roncero, A., Fernández-Elías, V. E., Guadalupe-Grau, A., Ortega, J. F., Dela, Flemming & Helge, Jørn Wulff, May 2016, In: Medicine and Science in Sports and Exercise. 48, 5, p. 822-828 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Subclinical Thyroid Dysfunction and Depressive Symptoms among Elderly: A Prospective Cohort Study

    Blum, M. R., Wijsman, L. W., Virgini, V. S., Bauer, D. C., den Elzen, W. P. J., Jukema, J. W., Buckley, B. M., de Craen, A. J. M., Kearney, P. M., Stott, D. J., Gussekloo, J., Westendorp, Rudi GJ, Mooijaart, S. P. & Rodondi, N., May 2016, In: Neuroendocrinology. 103, 3-4, p. 291-299 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes

    Lund, M. T., Kristensen, M. D., Hansen, M., Tveskov, L., Floyd, A. K., Støckel, M., Vainer, B., Poulsen, Steen Seier, Helge, Jørn Wulff, Prats Gavalda, Clara & Dela, Flemming, 6 Apr 2016, In: The Journal of Physiology. 594, 15, p. 4351-4358 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial

    Broekhuizen, K., de Gelder, J., Wijsman, C. A., Wijsman, L. W., Westendorp, Rudi GJ, Verhagen, E., Slagboom, P. E., de Craen, A. J., van Mechelen, W., van Heemst, D., van der Ouderaa, F. & Mooijaart, S. P., Apr 2016, In: Journal of Medical Internet Research. 18, 4, p. 1-11 11 p., e74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Calculating the Rate of Senescence From Mortality Data: An Analysis of Data From the ERA-EDTA Registry

    Koopman, J. J. E., Rozing, M. P., Kramer, A., Abad, J. M., Finne, P., Heaf, J. G., Hoitsma, A. J., De Meester, J. M. J., Palsson, R., Postorino, M., Ravani, P., Wanner, C., Jager, K. J., van Bodegom, D. & Westendorp, Rudi GJ, Apr 2016, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 71, 4, p. 468-474 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Disentangling rectangularization and life span extension with the moving rectangle method

    Schalkwijk, F. H., Koopman, J. J. E., Ghariq, E., de Beer, J. A. A., van Bodegom, D. & Westendorp, Rudi GJ, Mar 2016, In: Annals of Epidemiology. 26, 3, p. 218-221.e2 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  13. Published

    Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men

    Vigelsø Hansen, A., Gram, M., Wiuff, C., Hansen, C. N., Prats Gavalda, Clara, Dela, Flemming & Helge, Jørn Wulff, Mar 2016, In: European Journal of Applied Physiology. 116, 3, p. 481-494 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age

    Waaijer, M. E. C., Croco, E., Westendorp, Rudi GJ, Slagboom, P. E., Sedivy, J. M., Lorenzini, A. & Maier, A. B., 30 Jan 2016, In: Aging. 8, 1, p. 147-155 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Older persons' definitions and explanations of elder abuse in the Netherlands

    Mysyuk, Y., Westendorp, Rudi GJ & Lindenberg, J., 5 Jan 2016, In: Journal of Elder Abuse & Neglect. 28, 2, p. 95-113 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins

    Ponce-González, J. G., Ara, I., Larsen, Steen, Guerra, B., Calbet, J. A. L. & Helge, Jørn Wulff, Jan 2016, In: European Journal of Applied Physiology. 116, 1, 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

    Uth, J., Hornstrup, T., Christensen, J. F., Christensen, Karl Bang, Jørgensen, N. R., Helge, Eva Wulff, Schmidt, J. F., Brasso, K., Helge, Jørn Wulff, Jakobsen, M. D., Andersen, L. L., Rørth, M. R., Midtgaard, Julie & Krustrup, P., 2016, In: European Journal of Applied Physiology. 116, 3, p. 471-480 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men

    Vigelsø Hansen, A., Prats Gavalda, Clara, Ploug, Thorkil, Dela, Flemming & Helge, Jørn Wulff, 2016, In: Physiological Research. 65, 2, p. 293-302 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Moving in extreme environments: extreme loading; carriage versus distance

    Lucas, S. J. E., Helge, Jørn Wulff, Schütz, U. H. W., Goldman, R. F. & Cotter, J. D., 2016, In: Extreme Physiology & Medicine. 5, 14 p., 6.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Physiological responding to stress in middle-aged males enriched for longevity: a social stress study

    Jansen, S. W. M., van Heemst, D., van der Grond, J., Westendorp, Rudi GJ & Oei, N. Y. L., 2016, In: Stress: The International Journal on the Biology of Stress . 19, 1, p. 28-36 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Positive effects of 1-year football and strength training on mechanical muscle function and functional capacity in elderly men

    Sundstrup, E., Jakobsen, M. D., Andersen, L. L., Rostgaard Andersen, T., Randers, M. B., Helge, Jørn Wulff, Suetta, Charlotte, Schmidt, J. F., Bangsbo, Jens, Krustrup, P. & Aagaard, P., 2016, In: European Journal of Applied Physiology. 116, 6, p. 1127-1138 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Effect of Preoperative Type 2 Diabetes and Physical Fitness on Mental Health and Health-Related Quality of Life after Roux-en-Y Gastric Bypass

    Wimmelmann, Cathrine Lawaetz, Lund, M. T., Hansen, M., Dela, Flemming & Mortensen, Erik Lykke, 2016, In: Journal of Obesity. 2016, p. 1-9 9 p., 3474816.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate intensity exercise in human skeletal muscle

    Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A. B., Prats Gavalda, Clara, Greenhaff, P. L., Constantin-Teodosiu, D., Birk, Jesper Bratz, Wojtaszewski, Jørgen F P, Dela, Flemming & Helge, Jørn Wulff, 2016, In: Journal of Physiology. 594, 8, p. 2339-2358 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity

    Sogaard, D., Ostergard, T., Blachnio-Zabielska, A. U., Baranowski, M., Vigelsø Hansen, A., Andersen, J. L., Dela, Flemming & Helge, Jørn Wulff, 2016, In: Journal of Diabetes Research. 2016, 12 p., 2372741.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2015
  27. Published

    The Trade-Off between Female Fertility and Longevity during the Epidemiological Transition in the Netherlands

    Kaptijn, R., Thomese, F., Liefbroer, A. C., Van Poppel, F., Van Bodegom, D. & Westendorp, Rudi GJ, 17 Dec 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0144353.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Effects of angiotensin II receptor blockade on cerebral, cardiovascular, counter-regulatory, and symptomatic responses during hypoglycaemia in patients with type 1 diabetes

    Færch, L. H., Thorsteinsson, B., Tarnow, L., Holst, Jens Juul, Kjær, T. W., Kanters, Jørgen K., Larroude, C., Dela, Flemming & Pedersen-Bjergaard, Ulrik, Dec 2015, In: Journal of the Renin-Angiotensin-Aldosterone System. 16, 4, p. 1036-1045 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity

    Boushel, R., Gnaiger, E., Larsen, F. J., Helge, Jørn Wulff, González-Alonso, J., Ara, I., Munch-Andersen, T., van Hall, Gerrit, Søndergaard, H., Saltin, B. & Calbet, J. A. L., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25 , Supplement 4, p. 135-143 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Ultrastructural myocardial changes in seven cats with spontaneous hypertrophic cardiomyopathy

    Christiansen, L. B., Prats Gavalda, Clara, Hyttel, P. & Koch, Jørgen, Dec 2015, In: Journal of Veterinary Cardiology. 17 , Suppl. 1, p. S220-S232 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Seasonal Variation in Mortality, Medical Care Expenditure and Institutionalization in Older People: Evidence from a Dutch Cohort of Older Health Insurance Clients

    Rolden, H. J. A., Rohling, J. H. T., van Bodegom, D. & Westendorp, Rudi GJ, 16 Nov 2015, In: PLOS ONE. 10, 11, p. 1-14 15 p., e0143154.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

    van der Spoel, E., Rozing, M. P., Houwing-Duistermaat, J. J., Slagboom, P. E., Beekman, M., de Craen, A. J. M., Westendorp, Rudi GJ & van Heemst, D., 12 Nov 2015, In: Aging. 7, 11, p. 956–963 8 p., PMC4694065.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Desler, Claus, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, G., Fagerlund, Birgitte, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In: Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

    Bis, J. C., Sitlani, C., Irvin, R., Avery, C. L., Smith, A. V., Sun, F., Evans, D. S., Musani, S. K., Li, X., Trompet, S., Krijthe, B. P., Harris, T. B., Quibrera, P. M., Brody, J. A., Demissie, S., Davis, B. R., Wiggins, K. L., Tranah, G. J., Lange, L. A., Sotoodehnia, N. & 34 others, Stott, D. J., Franco, O. H., Launer, L. J., Stürmer, T., Taylor, K. D., Cupples, L. A., Eckfeldt, J. H., Smith, N. L., Liu, Y., Wilson, J. G., Heckbert, S. R., Buckley, B. M., Ikram, M. A., Boerwinkle, E., Chen, Y. I., de Craen, A. J. M., Uitterlinden, A. G., Rotter, J. I., Ford, I., Hofman, A., Sattar, N., Slagboom, P. E., Westendorp, Rudi GJ, Gudnason, V., Vasan, R. S., Lumley, T., Cummings, S. R., Taylor, H. A., Post, W., Jukema, J. W., Stricker, B. H., Whitsel, E. A., Psaty, B. M. & Arnett, D., 30 Oct 2015, In: PLOS ONE. 10, 10, p. 1-13 13 p., e0140496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Resting heart rate, heart rate variability and functional decline in old age

    Ogliari, G., Mahinrad, S., Stott, D. J., Jukema, J. W., Mooijaart, S. P., Macfarlane, P. W., Clark, E. N., Kearney, P. M., Westendorp, Rudi GJ, de Craen, A. J. M. & Sabayan, B., 20 Oct 2015, In: C M A J. 187, 15, p. E442-E449 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

    Akintola, A. A., Noordam, R., Jansen, S. W., de Craen, A. J., Ballieux, B. E., Cobbaert, C. M., Mooijaart, S. P., Pijl, H., Westendorp, Rudi GJ & van Heemst, D., 7 Oct 2015, In: PloS one. 10, 10, p. 1-13 13 p., e0139973.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Blood temperature and perfusion to exercising and non-exercising human limbs

    González-Alonso, J., Calbet, J. A. L., Boushel, R., Helge, Jørn Wulff, Søndergaard, H., Munch-Andersen, T., van Hall, Gerrit, Mortensen, S. P. & Secher, Niels H., 1 Oct 2015, In: Experimental Physiology. 100, 10, p. 1118-1131 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB

    Hansen, M., Lund, M. T., Gregers, E., Kraunsøe, R., van Hall, Gerrit, Helge, Jørn Wulff & Dela, Flemming, Oct 2015, In: Obesity. 23, 10, p. 2022-2229 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration

    Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning-the DANTE Study Leiden: A Randomized Clinical Trial

    Moonen, J. E. F., Foster-Dingley, J. C., de Ruijter, W., van der Grond, J., Bertens, A. S., van Buchem, M. A., Gussekloo, J., Middelkoop, H. A., Wermer, M. J. H., Westendorp, Rudi GJ, de Craen, A. J. M. & van der Mast, R. C., Oct 2015, In: J A M A Internal Medicine. 175, 10, p. 1622-1630 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship

    Jansen, S. W., Roelfsema, F., van der Spoel, E., Akintola, A. A., Postmus, I., Ballieux, B. E., Slagboom, P. E., Cobbaert, C. M., van der Grond, J., Westendorp, Rudi GJ, Pijl, H. & van Heemst, D., Oct 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. 3806-3813 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The Effect of Reduced Physical Activity and Retraining on Blood Lipids and Body Composition in Young and Older Adult Men

    Nørregaard, J., Gram, M., Vigelsø , A., Wiuff, C., Kuhlman, A. B., Helge, Jørn Wulff & Dela, Flemming, Oct 2015, In: Journal of Aging and Physical Activity. 23, 4, p. 489-495 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

    Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Executive function, but not memory, associates with incident coronary heart disease and stroke

    Rostamian, S., van Buchem, M. A., Westendorp, Rudi GJ, Jukema, J. W., Mooijaart, S. P., Sabayan, B. & de Craen, A. J. M., 1 Sep 2015, In: Neurology. 85, 9, p. 783-789 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Skeletal muscle mitochondrial H2O2 emission increases with immobilization and decreases after aerobic training in young and older men

    Gram, M., Vigelsø, A., Yokota, T., Helge, Jørn Wulff, Dela, Flemming & Hey-Mogensen, M., 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 4011-4027 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Age- and Functional Status-Dependent Association Between Blood Pressure and Cognition: The Milan Geriatrics 75+ Cohort Study

    Ogliari, G., Sabayan, B., Mari, D., Rossi, P. D., Lucchi, T. A., de Craen, A. J. M. & Westendorp, Rudi GJ, Sep 2015, In: Journal of the American Geriatrics Society. 63, 9, p. 1741-1748 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis

    Akintola, A. A., Jansen, S. W., van Bodegom, D., van der Grond, J., Westendorp, Rudi GJ, de Craen, A. J. M. & van Heemst, D., 11 Aug 2015, In: Frontiers in Aging Neuroscience. 7, p. 1-11 11 p., 150.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, M., Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In: Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics

    Kristensen, M., Pötzelsberger, B., Scheiber, P., Bergdahl, A., Hansen, C. N., Andersen, J. L., Narici, M., Salvioli, S., Conte, M., Müller, E. & Dela, Flemming, Aug 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Supplement S2, p. 40-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Alpine Skiing With total knee ArthroPlasty (ASWAP): study design and intervention

    Koesters, A., Poetzelsberger, B., Dela, Flemming, Dorn, U., Hofstaedter, T., Fink, C. & Mueller, E., Aug 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Supplement S2, p. 3-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Effect of moderate- versus high-intensity exercise on vascular function, biomarkers and quality of life in heart transplant recipients: A randomized, crossover trial

    Dall, Christian Have, Gustafsson, F., Christensen, S. B., Dela, Flemming, Langberg, Henning & Prescott, Eva, Aug 2015, In: Journal of Heart and Lung Transplantation. 34, 8, p. 1033–1041 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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