- 2016
- Published
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In: Cell Reports. 16, 1, p. 161-173 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study
Koopman, J. J. E., Pijpe, J., Böhringer, S., van Bodegom, D., Eriksson, U. K., Sanchez-Faddeev, H., Ziem, J. B., Zwaan, B., Slagboom, P. E., de Knijff, P. & Westendorp, Rudi GJ, 27 Jun 2016, In: Aging. 8, 7, p. 1364-1383 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquired Localized Cutis Laxa due to Increased Elastin Turnover
Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Emerging Epidemic of Noncommunicable Diseases in Developing Populations Due to a Triple Evolutionary Mismatch
Koopman, J. J. E., van Bodegom, D., Ziem, J. B. & Westendorp, Rudi GJ, Jun 2016, In: American Journal of Tropical Medicine and Hygiene. 94, 6, p. 1189-1192 4 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes
Hansen, M., Lund, M. T., Jørgensen, A. L. K., Palsøe, M. K., van Hall, Gerrit, Helge, Jørn Wulff & Dela, Flemming, Jun 2016, In: Acta Diabetologica. 53, 3, p. 423–432 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aerobic Exercise Training Increases Muscle Water Content in Obese Middle-Age Men
Mora-Rodríguez, R., Sanchez-Roncero, A., Fernández-Elías, V. E., Guadalupe-Grau, A., Ortega, J. F., Dela, Flemming & Helge, Jørn Wulff, May 2016, In: Medicine and Science in Sports and Exercise. 48, 5, p. 822-828 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subclinical Thyroid Dysfunction and Depressive Symptoms among Elderly: A Prospective Cohort Study
Blum, M. R., Wijsman, L. W., Virgini, V. S., Bauer, D. C., den Elzen, W. P. J., Jukema, J. W., Buckley, B. M., de Craen, A. J. M., Kearney, P. M., Stott, D. J., Gussekloo, J., Westendorp, Rudi GJ, Mooijaart, S. P. & Rodondi, N., May 2016, In: Neuroendocrinology. 103, 3-4, p. 291-299 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes
Lund, M. T., Kristensen, M. D., Hansen, M., Tveskov, L., Floyd, A. K., Støckel, M., Vainer, B., Poulsen, Steen Seier, Helge, Jørn Wulff, Prats Gavalda, Clara & Dela, Flemming, 6 Apr 2016, In: The Journal of Physiology. 594, 15, p. 4351-4358 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial
Broekhuizen, K., de Gelder, J., Wijsman, C. A., Wijsman, L. W., Westendorp, Rudi GJ, Verhagen, E., Slagboom, P. E., de Craen, A. J., van Mechelen, W., van Heemst, D., van der Ouderaa, F. & Mooijaart, S. P., Apr 2016, In: Journal of Medical Internet Research. 18, 4, p. 1-11 11 p., e74.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calculating the Rate of Senescence From Mortality Data: An Analysis of Data From the ERA-EDTA Registry
Koopman, J. J. E., Rozing, M. P., Kramer, A., Abad, J. M., Finne, P., Heaf, J. G., Hoitsma, A. J., De Meester, J. M. J., Palsson, R., Postorino, M., Ravani, P., Wanner, C., Jager, K. J., van Bodegom, D. & Westendorp, Rudi GJ, Apr 2016, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 71, 4, p. 468-474 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disentangling rectangularization and life span extension with the moving rectangle method
Schalkwijk, F. H., Koopman, J. J. E., Ghariq, E., de Beer, J. A. A., van Bodegom, D. & Westendorp, Rudi GJ, Mar 2016, In: Annals of Epidemiology. 26, 3, p. 218-221.e2 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men
Vigelsø Hansen, A., Gram, M., Wiuff, C., Hansen, C. N., Prats Gavalda, Clara, Dela, Flemming & Helge, Jørn Wulff, Mar 2016, In: European Journal of Applied Physiology. 116, 3, p. 481-494 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age
Waaijer, M. E. C., Croco, E., Westendorp, Rudi GJ, Slagboom, P. E., Sedivy, J. M., Lorenzini, A. & Maier, A. B., 30 Jan 2016, In: Aging. 8, 1, p. 147-155 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Older persons' definitions and explanations of elder abuse in the Netherlands
Mysyuk, Y., Westendorp, Rudi GJ & Lindenberg, J., 5 Jan 2016, In: Journal of Elder Abuse & Neglect. 28, 2, p. 95-113 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins
Ponce-González, J. G., Ara, I., Larsen, Steen, Guerra, B., Calbet, J. A. L. & Helge, Jørn Wulff, Jan 2016, In: European Journal of Applied Physiology. 116, 1, 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations
Uth, J., Hornstrup, T., Christensen, J. F., Christensen, Karl Bang, Jørgensen, N. R., Helge, Eva Wulff, Schmidt, J. F., Brasso, K., Helge, Jørn Wulff, Jakobsen, M. D., Andersen, L. L., Rørth, M. R., Midtgaard, Julie & Krustrup, P., 2016, In: European Journal of Applied Physiology. 116, 3, p. 471-480 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men
Vigelsø Hansen, A., Prats Gavalda, Clara, Ploug, Thorkil, Dela, Flemming & Helge, Jørn Wulff, 2016, In: Physiological Research. 65, 2, p. 293-302 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
Christensen, Christa Lykke, Helge, Jørn Wulff, Krasnik, Allan, Kriegbaum, Margit, Rasmussen, Lene Juel, Hickson, Ian David, Liisberg, Kasper Bering, Oxlund, Bjarke, Bruun, B., Lau, Sofie Rosenlund, Olsen, M. N. A., Andersen, John Sahl, Heltberg, Andreas Søndergaard, Kuhlman, A. C. B., Morville, T. H., Dohlmann, T. L., Larsen, Steen & Dela, Flemming, 2016, In: Scandinavian Journal of Public Health. 44, 5, p. 534-539 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Moving in extreme environments: extreme loading; carriage versus distance
Lucas, S. J. E., Helge, Jørn Wulff, Schütz, U. H. W., Goldman, R. F. & Cotter, J. D., 2016, In: Extreme Physiology & Medicine. 5, 14 p., 6.Research output: Contribution to journal › Review › Research › peer-review
- Published
Physiological responding to stress in middle-aged males enriched for longevity: a social stress study
Jansen, S. W. M., van Heemst, D., van der Grond, J., Westendorp, Rudi GJ & Oei, N. Y. L., 2016, In: Stress: The International Journal on the Biology of Stress . 19, 1, p. 28-36 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive effects of 1-year football and strength training on mechanical muscle function and functional capacity in elderly men
Sundstrup, E., Jakobsen, M. D., Andersen, L. L., Rostgaard Andersen, T., Randers, M. B., Helge, Jørn Wulff, Suetta, Charlotte, Schmidt, J. F., Bangsbo, Jens, Krustrup, P. & Aagaard, P., 2016, In: European Journal of Applied Physiology. 116, 6, p. 1127-1138 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Preoperative Type 2 Diabetes and Physical Fitness on Mental Health and Health-Related Quality of Life after Roux-en-Y Gastric Bypass
Wimmelmann, Cathrine Lawaetz, Lund, M. T., Hansen, M., Dela, Flemming & Mortensen, Erik Lykke, 2016, In: Journal of Obesity. 2016, p. 1-9 9 p., 3474816.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate intensity exercise in human skeletal muscle
Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A. B., Prats Gavalda, Clara, Greenhaff, P. L., Constantin-Teodosiu, D., Birk, Jesper Bratz, Wojtaszewski, Jørgen F P, Dela, Flemming & Helge, Jørn Wulff, 2016, In: Journal of Physiology. 594, 8, p. 2339-2358 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
Sogaard, D., Ostergard, T., Blachnio-Zabielska, A. U., Baranowski, M., Vigelsø Hansen, A., Andersen, J. L., Dela, Flemming & Helge, Jørn Wulff, 2016, In: Journal of Diabetes Research. 2016, 12 p., 2372741.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
The Trade-Off between Female Fertility and Longevity during the Epidemiological Transition in the Netherlands
Kaptijn, R., Thomese, F., Liefbroer, A. C., Van Poppel, F., Van Bodegom, D. & Westendorp, Rudi GJ, 17 Dec 2015, In: PloS one. 10, 12, p. 1-11 11 p., e0144353.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of angiotensin II receptor blockade on cerebral, cardiovascular, counter-regulatory, and symptomatic responses during hypoglycaemia in patients with type 1 diabetes
Færch, L. H., Thorsteinsson, B., Tarnow, L., Holst, Jens Juul, Kjær, T. W., Kanters, Jørgen K., Larroude, C., Dela, Flemming & Pedersen-Bjergaard, Ulrik, Dec 2015, In: Journal of the Renin-Angiotensin-Aldosterone System. 16, 4, p. 1036-1045 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity
Boushel, R., Gnaiger, E., Larsen, F. J., Helge, Jørn Wulff, González-Alonso, J., Ara, I., Munch-Andersen, T., van Hall, Gerrit, Søndergaard, H., Saltin, B. & Calbet, J. A. L., Dec 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25 , Supplement 4, p. 135-143 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultrastructural myocardial changes in seven cats with spontaneous hypertrophic cardiomyopathy
Christiansen, L. B., Prats Gavalda, Clara, Hyttel, P. & Koch, Jørgen, Dec 2015, In: Journal of Veterinary Cardiology. 17 , Suppl. 1, p. S220-S232 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seasonal Variation in Mortality, Medical Care Expenditure and Institutionalization in Older People: Evidence from a Dutch Cohort of Older Health Insurance Clients
Rolden, H. J. A., Rohling, J. H. T., van Bodegom, D. & Westendorp, Rudi GJ, 16 Nov 2015, In: PLOS ONE. 10, 11, p. 1-14 15 p., e0143154.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
van der Spoel, E., Rozing, M. P., Houwing-Duistermaat, J. J., Slagboom, P. E., Beekman, M., de Craen, A. J. M., Westendorp, Rudi GJ & van Heemst, D., 12 Nov 2015, In: Aging. 7, 11, p. 956–963 8 p., PMC4694065.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline
Desler, Claus, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, G., Fagerlund, Birgitte, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In: Mitochondrion. 25, p. 34-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium
Bis, J. C., Sitlani, C., Irvin, R., Avery, C. L., Smith, A. V., Sun, F., Evans, D. S., Musani, S. K., Li, X., Trompet, S., Krijthe, B. P., Harris, T. B., Quibrera, P. M., Brody, J. A., Demissie, S., Davis, B. R., Wiggins, K. L., Tranah, G. J., Lange, L. A., Sotoodehnia, N. & 34 others, , 30 Oct 2015, In: PLOS ONE. 10, 10, p. 1-13 13 p., e0140496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resting heart rate, heart rate variability and functional decline in old age
Ogliari, G., Mahinrad, S., Stott, D. J., Jukema, J. W., Mooijaart, S. P., Macfarlane, P. W., Clark, E. N., Kearney, P. M., Westendorp, Rudi GJ, de Craen, A. J. M. & Sabayan, B., 20 Oct 2015, In: C M A J. 187, 15, p. E442-E449 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals
Akintola, A. A., Noordam, R., Jansen, S. W., de Craen, A. J., Ballieux, B. E., Cobbaert, C. M., Mooijaart, S. P., Pijl, H., Westendorp, Rudi GJ & van Heemst, D., 7 Oct 2015, In: PloS one. 10, 10, p. 1-13 13 p., e0139973.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood temperature and perfusion to exercising and non-exercising human limbs
González-Alonso, J., Calbet, J. A. L., Boushel, R., Helge, Jørn Wulff, Søndergaard, H., Munch-Andersen, T., van Hall, Gerrit, Mortensen, S. P. & Secher, Niels H., 1 Oct 2015, In: Experimental Physiology. 100, 10, p. 1118-1131 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB
Hansen, M., Lund, M. T., Gregers, E., Kraunsøe, R., van Hall, Gerrit, Helge, Jørn Wulff & Dela, Flemming, Oct 2015, In: Obesity. 23, 10, p. 2022-2229 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning-the DANTE Study Leiden: A Randomized Clinical Trial
Moonen, J. E. F., Foster-Dingley, J. C., de Ruijter, W., van der Grond, J., Bertens, A. S., van Buchem, M. A., Gussekloo, J., Middelkoop, H. A., Wermer, M. J. H., Westendorp, Rudi GJ, de Craen, A. J. M. & van der Mast, R. C., Oct 2015, In: J A M A Internal Medicine. 175, 10, p. 1622-1630 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship
Jansen, S. W., Roelfsema, F., van der Spoel, E., Akintola, A. A., Postmus, I., Ballieux, B. E., Slagboom, P. E., Cobbaert, C. M., van der Grond, J., Westendorp, Rudi GJ, Pijl, H. & van Heemst, D., Oct 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 10, p. 3806-3813 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Reduced Physical Activity and Retraining on Blood Lipids and Body Composition in Young and Older Adult Men
Nørregaard, J., Gram, M., Vigelsø , A., Wiuff, C., Kuhlman, A. B., Helge, Jørn Wulff & Dela, Flemming, Oct 2015, In: Journal of Aging and Physical Activity. 23, 4, p. 489-495 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function
Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Executive function, but not memory, associates with incident coronary heart disease and stroke
Rostamian, S., van Buchem, M. A., Westendorp, Rudi GJ, Jukema, J. W., Mooijaart, S. P., Sabayan, B. & de Craen, A. J. M., 1 Sep 2015, In: Neurology. 85, 9, p. 783-789 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skeletal muscle mitochondrial H2O2 emission increases with immobilization and decreases after aerobic training in young and older men
Gram, M., Vigelsø, A., Yokota, T., Helge, Jørn Wulff, Dela, Flemming & Hey-Mogensen, M., 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 4011-4027 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age- and Functional Status-Dependent Association Between Blood Pressure and Cognition: The Milan Geriatrics 75+ Cohort Study
Ogliari, G., Sabayan, B., Mari, D., Rossi, P. D., Lucchi, T. A., de Craen, A. J. M. & Westendorp, Rudi GJ, Sep 2015, In: Journal of the American Geriatrics Society. 63, 9, p. 1741-1748 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis
Akintola, A. A., Jansen, S. W., van Bodegom, D., van der Grond, J., Westendorp, Rudi GJ, de Craen, A. J. M. & van Heemst, D., 11 Aug 2015, In: Frontiers in Aging Neuroscience. 7, p. 1-11 11 p., 150.Research output: Contribution to journal › Review › Research › peer-review
- Published
Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells
Akbari, M., Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In: Scientific Reports. 5, 8 p., 12876 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics
Kristensen, M., Pötzelsberger, B., Scheiber, P., Bergdahl, A., Hansen, C. N., Andersen, J. L., Narici, M., Salvioli, S., Conte, M., Müller, E. & Dela, Flemming, Aug 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Supplement S2, p. 40-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Alpine Skiing With total knee ArthroPlasty (ASWAP): study design and intervention
Koesters, A., Poetzelsberger, B., Dela, Flemming, Dorn, U., Hofstaedter, T., Fink, C. & Mueller, E., Aug 2015, In: Scandinavian Journal of Medicine & Science in Sports. 25, Supplement S2, p. 3-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of moderate- versus high-intensity exercise on vascular function, biomarkers and quality of life in heart transplant recipients: A randomized, crossover trial
Dall, Christian Have, Gustafsson, F., Christensen, S. B., Dela, Flemming, Langberg, Henning & Prescott, Eva, Aug 2015, In: Journal of Heart and Lung Transplantation. 34, 8, p. 1033–1041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
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Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness
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