Individualized Health

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  1. 2019
  2. Published

    Statin Treatment Decreases Mitochondrial Respiration But Muscle Coenzyme Q10 Levels Are Unaltered: The LIFESTAT Study

    Dohlmann, T. L., Morville, T., Kuhlman, A. B., Chrøis, K. M., Helge, Jørn Wulff, Dela, Flemming & Larsen, Steen, Jul 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 7, p. 2501–2508

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

    Hjerrild, J. N., Wobbe, A., Stausholm, M. B., Larsen, A. E., Josefsen, C. O., Malmgaard-Clausen, N. M., Dela, Flemming, Kjær, Michael, Magnusson, Stig Peter, Hansen, M., Svensson, R. B. & Couppé, C., 22 Jun 2019, In: Nutrients. 11, 6

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    GIP-induced vasodilation in human adipose tissue involves capillary recruitment

    Asmar, M., Asmar, A., Simonsen, L., Dela, Flemming, Holst, Jens Juul & Bulow, J., Jun 2019, In: Endocrine Connections. 8, 6, p. 806-813

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

    Graae, A-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A., Kiens, B. & 10 others, Wojtaszewski, Jørgen F P, Larsen, Steen, Apte, S. S., Häring, H., Vaag, A., Zethelius, B., Pedersen, Oluf Borbye, Treebak, Jonas Thue, Hansen, Torben & Holst, Birgitte, 2019, In: Diabetes. 68, 3, p. 502-514

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Aerobic Exercise Performance and Muscle Strength in Statin Users-The LIFESTAT Study

    Morville, T., Dohlmann, T. L., Kuhlman, A. B., Sahl, Ronni Eg, Kriegbaum, Margit, Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Medicine and Science in Sports and Exercise. 51, 7, p. 1429-1437 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle

    de Guia, R. M., Agerholm, M., Nielsen, Thomas Svava, Consitt, L. A., Sogaard, D., Helge, Jørn Wulff, Larsen, Steen, Brandauer, J., Houmard, J. A. & Treebak, Jonas Thue, 2019, In: Physiological Reports. 7, 12, 15 p., e14139.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Aging in high functioning elderly persons: study design and analyses of behavioral and psychological factors

    Finkenzeller, T., Poetzelsberger, B., Koesters, A., Wuerth, S., Amesberger, G., Dela, Flemming & Mueller, E., 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, p. 7-16

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Are skin senescence and immunosenescence linked within individuals?

    Waaijer, M. E. C., Goldeck, D., Gunn, D. A., van Heemst, D., Westendorp, Rudi GJ, Pawelec, G. & Maier, A. B., 2019, In: Aging Cell. 18, 4, 5 p., e12956.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Assessment of maximal fat oxidation during exercise: A systematic review

    Amaro-Gahete, F. J., Sanchez-Delgado, G., Jurado-Fasoli, L., De-la-O, A., Castillo, M. J., Helge, Jørn Wulff & Ruiz, J. R., 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, 7, p. 910-921

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

    Mooijaart, S. P., Du Puy, R. S., Stott, D. J., Kearney, P. M., Rodondi, N., Westendorp, R. G. J., den Elzen, W. P. J., Postmus, I., Poortvliet, R. K. E., van Heemst, D., van Munster, B. C., Peeters, R. P., Ford, I., Kean, S., Messow, C-M., Blum, M. R., Collet, T-H., Watt, T., Dekkers, O. M., Jukema, J. W. & 3 others, Smit, J. W. A., Langhorne, P. & Gussekloo, J., 2019, In: J A M A: The Journal of the American Medical Association. 322, 20, p. 1977-1986 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Cardiovascular, muscular, and skeletal adaptations to recreational team handball training: a randomized controlled trial with young adult untrained men

    Hornstrup, T., Løwenstein, F. T., Larsen, M. A., Helge, Eva Wulff, Póvoas, S., Helge, Jørn Wulff, Nielsen, Jens Jung, Fristrup, B., Andersen, J. L., Gliemann, Lasse, Nybo, Lars & Krustrup, P., 2019, In: European Journal of Applied Physiology. 119, 2, p. 561-573 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Clusters of Glycemic Response to Oral Glucose Tolerance Tests Explain Multivariate Metabolic and Anthropometric Outcomes of Bariatric Surgery in Obese Patients

    Szczerbinski, L., Taylor, M. A., Citko, A., Gorska, M., Larsen, Steen, Hady, H. R. & Kretowski, A., 2019, In: Journal of Clinical Medicine. 8, 8, 16 p., 1091.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

    Lee, J., Demarest, T. G., Babbar, M., Kim, E. W., Okur, M. N., De, S., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 16, p. 8548-8562

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Coenzyme Q10 does not improve peripheral insulin sensitivity in statin-treated men and women: the LIFESTAT study

    Kuhlman, A. B., Morville, T., Dohlmann, T. L., Hansen, M., Kelly, B., Helge, Jørn Wulff & Dela, Flemming, 2019, In: Applied Physiology, Nutrition and Metabolism. 44, p. 485–492

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Copenhagen Consensus statement 2019: Physical activity and ageing

    Bangsbo, J., Blackwell, J., Boraxbekk, C-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjær, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., Skinner, T. & 6 others, Skovgaard, T., Troelsen, J., Tulle, E., Tully, M. A., van Uffelen, J. G. Z. & Viña, J., 2019, In: British Journal of Sports Medicine. 53, 14, p. 856-858 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Determination and validation of peak fat oxidation in endurance-trained men using an upper body graded exercise test

    Hansen, Mikkel Thunestvedt, Rømer, Tue, Frandsen, J., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, 11, p. 1677-1690

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

    Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2019, In: Nucleic Acids Research. 47, 8, p. 4086–4110

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Diurnal Variation of Maximal Fat-Oxidation Rate in Trained Male Athletes

    Amaro-Gahete, F. J., Jurado-Fasoli, L., Trivino, A. R., Sanchez-Delgado, G., De-la-O, A., Helge, Jørn Wulff & Ruiz, J. R., 2019, In: International Journal of Sports Physiology and Performance. 14, 8, p. 1140-1146

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Do psychosocial factors modify the negative association between disability and life satisfaction in old age?

    Puvill, T., Kusumastuti, S., Lund, Rikke, Mortensen, Erik Lykke, Slaets, J., Lindenberg, J. & Westendorp, Rudi GJ, 2019, In: P L o S One. 14, 10, 15 p., e0224421.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Effect of the mineralocorticoid receptor antagonist eplerenone on liver fat and metabolism in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial (MIRAD trial)

    Johansen, M. L., Schou, Morten, Rossignol, P., Holm, M. R., Rasmussen, J., Brandt, N., Frandsen, M., Chabanova, E., Dela, Flemming, Faber, Jens & Kistorp, Caroline Michaela Nervil, 2019, In: Diabetes, Obesity and Metabolism. 21, 10, p. 2305-2314 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

    Dela, Flemming, Ingersen, Arthur, Andersen, N. B., Nielsen, M. B., Petersen, H. H. H., Hansen, C. N., Larsen, Steen, Wojtaszewski, Jørgen F P & Helge, Jørn Wulff, 2019, In: Acta Physiologica (Print). 226, 2, 18 p., e13245.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Glucose metabolism dysregulation affects the transcriptome of skeletal muscle and responds to three-month exercise intervention in humans

    Szczerbinski, L., Niemira, M., Szczerbinski, K., Puchta, U., Taylor, M., Citko, A., Siewiec, E., Zapolska, J., Larsen, Steen, Gorska, M. & Kretowski, A., 2019, In: Diabetologia. 62, Supl. 1/SI, p. S66-S66 127.

    Research output: Contribution to journal › Conference abstract in journal › Research

  24. Published

    Impact of data analysis methods for maximal fat oxidation estimation during exercise in sedentary adults Data analysis maximal fat oxidation

    Amaro-Gahete, F. J., Sanchez-Delgado, G., Alcantara, J. M. A., Martinez-Tellez, B., Acosta, F. M., Helge, Jørn Wulff & Ruiz, J. R., 2019, In: European Journal of Sport Science. 19, 9, p. 1230-1239,

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis

    Nakajima, T., Yokota, T., Shingu, Y., Yamada, A., Iba, Y., Ujihira, K., Wakasa, S., Ooka, T., Takada, S., Shirakawa, R., Katayama, T., Furihata, T., Fukushima, A., Matsuoka, R., Nishihara, H., Dela, Flemming, Nakanishi, K., Matsui, Y. & Kinugawa, S., 2019, In: Scientific Reports. 9, 1, 3535.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

    Nielsen, B., Cejvanovic, V., Wortwein, G., Hansen, A. R., Marstal, K. K., Weimann, A., Bjerring, P. N., Dela, Flemming, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 2019, In: Neuroscience Letters. 690, p. 1-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Inflammatory biomarkers in patients in Simvastatin treatment: No effect of co-enzyme Q10 supplementation

    Hansen, M., Kuhlman, A. C. B., Sahl, Ronni Eg, Kelly, B., Morville, T., Dohlmann, T. L., Chrøis, K. M., Larsen, S., Helge, Jørn Wulff & Dela, Flemming, 2019, In: Cytokine. 113, p. 393-399 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans

    Larsen, Steen, Dandanell, S., Kristensen, K. B., Jorgensen, S. D., Dela, Flemming & Helge, Jørn Wulff, 2019, In: Applied Physiology, Nutrition and Metabolism. 44, 9, p. 958-964

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes

    Johansen, M. L., Schou, Morten, Rasmussen, J., Rossignol, P., Holm, M. R., Chabanova, E., Dela, Flemming, Faber, Jens & Kistorp, Caroline Michaela Nervil, 2019, In: Diabetes & Metabolism. 45, 5, p. 429-435

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, M., Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In: Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

    Dall, M., Trammell, Sam, Asping, M., Hassing, Anna Skab, Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, Steen & Treebak, Jonas Thue, 2019, In: The Journal of Biological Chemistry. 294, 36, p. 13304-13326 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

    Shirakawa, R., Yokota, T., Nakajima, T., Takada, S., Yamane, M., Furihata, T., Maekawa, S., Nambu, H., Katayama, T., Fukushima, A., Saito, A., Ishimori, N., Dela, Flemming, Kinugawa, S. & Anzai, T., 2019, In: Scientific Reports. 9, 8 p., 14709.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In: Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training

    Søgaard, D., Baranowski, M., Larsen, Steen, Taulo Lund, M., Munk Scheuer, C., Vestergaard Abildskov, C., Greve Dideriksen, S., Dela, Flemming & Helge, Jørn Wulff, 2019, In: International Journal of Molecular Sciences . 20, 5, 1240.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H-J., Kato, H., Kassahun, H., Lee, J-H., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L. & 9 others, Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In: Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

    Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Free Radical Biology and Medicine. 141, p. 47-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Night shift work, long working hours and dementia: a longitudinal study of the Danish Work Environment Cohort

    Nabe-Nielsen, Kirsten, Hansen, Åse Marie, Ishtiak-Ahmed, K., Brodsgaard Grynderup, M., Gyntelberg, F., Islamoska, S., Mortensen, Erik Lykke, Phung, T. K. T., Rod, Naja Hulvej, Waldemar, Gunhild, Westendorp, Rudi GJ & Garde, A. H., 2019, In: BMJ Open.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Optimizing Maximal Fat Oxidation Assessment by a Treadmill-Based Graded Exercise Protocol: When Should the Test End?

    Amaro-Gahete, F. J., Sanchez-Delgado, G., Helge, Jørn Wulff & Ruiz, J. R., 2019, In: Frontiers in Physiology. 10, 5 p., 909.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Plasma free fatty acid concentration is closely tied to whole-body peak fat oxidation rate during repeated exercise

    Frandsen, J., Vest, S. D., Ritz, C., Larsen, Steen, Dela, Flemming & Helge, Jørn Wulff, 2019, In: Journal of Applied Physiology. 126, 6, p. 1563-1571 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Pre-ischemic succinate dehydrogenase inhibition is protective against ischemia-reperfusion injury in rat and human myocardium with and without diabetes mellitus: [Meeting Abstract]

    Jespersen, N. R., Hjortbak, M. V., Lassen, T. R., Stoettrup, N. B., Johnsen, J., Tonnesen, P. T., Larsen, Steen, Kimose, H. H. & Boetker, H. E., 2019, In: European Heart Journal. 40, S.1, p. 2101-2101 P3487 .

    Research output: Contribution to journal › Conference abstract in journal › Research

  42. Published

    Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies

    Wildisen, L., Moutzouri, E., Beglinger, S., Syrogiannouli, L., Cappola, A. R., Åsvold, B. O., Bakker, S. J. L., Ceresini, G., Dullaart, R., Ferrucci, L., Grabe, H., Jukema, J. W., Nauck, M., Trompet, S., Voelzke, H., Westendorp, R. G. J., Gussekloo, J., Peeters, R. P., Kloeppel, S., Aujesky, D. & 4 others, Bauer, D. C., Rodondi, N., Del Giovane, C. & Feller, M., 2019, In: BMJ Open. 9, 7, 4 p., 029716.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    The influence of age and cardiorespiratory fitness on bioactive lipids in muscle

    Søgaard, D., Baranowski, M., Dela, Flemming & Helge, Jørn Wulff, 2019, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 6, p. 778-786

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The rise of statins in Denmark: Making the case for a localized approach to the routinization of pharmaceutical prevention of cardiovascular disease

    Lau, Sofie Rosenlund, Andersen, John Sahl, Dela, Flemming & Oxlund, Bjarke, 2019, In: BioSocieties. 14, 2, p. 228-250 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Trajectories of cardio-metabolic health in successful aging

    Dela, Flemming, Finkenzeller, T., Ingersen, Arthur, Poetzelsberger, B. & Mueller, E., 2019, In: Scandinavian Journal of Medicine & Science in Sports. 29, p. 44-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2018
  47. Published

    Obesity leads to impairments in the morphology and organization of human skeletal muscle lipid droplets and mitochondrial networks, which are resolved with gastric bypass surgery-induced improvements in insulin sensitivity

    Kristensen, M. D., Petersen, S. M., Møller, Kristina, Lund, Morten Asp Vonsild, Hansen, M., Hansen, C. N., Courraud, J., Helge, Jørn Wulff, Dela, Flemming & Prats Gavalda, Clara, Dec 2018, In: Acta Physiologica (Print). 224, 4, 15 p., e13100 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The combination of cardiorespiratory fitness and muscle strength, and mortality risk

    Kim, Y., White, T., Wijndaele, K., Westgate, K., Sharp, S. J., Helge, Jørn Wulff, Wareham, N. J. & Brage, S., 1 Oct 2018, In: European Journal of Epidemiology. 33, 10, p. 953-964 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle

    Dohlmann, T. L., Hindsø, M., Dela, Flemming, Helge, Jørn Wulff & Larsen, S., 1 Sep 2018, In: Physiological Reports. 6, 18, p. 1-11 e13857.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Variation in mitochondrial respiratory capacity and myosin heavy chain composition in repeated muscle biopsies

    Sahl, Ronni Eg, Morville, T., Kraunsøe, R., Dela, Flemming, Helge, Jørn Wulff & Larsen, Steen, 1 Sep 2018, In: Analytical Biochemistry. 556, p. 119-124 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery

    Lund, M. T., Larsen, Steen, Hansen, M., Courraud, J., Floyd, A. K., Støckel, M., Helge, Jørn Wulff & Dela, Flemming, 1 May 2018, In: Acta Physiologica. 223, 1, p. 1-9 e13032.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    High-intensity interval training improves insulin sensitivity in older individuals

    Søgaard, D., Lund, M. T., Scheuer, C. M., Dehlbaek, M. S., Dideriksen, S. G., Abildskov, C. V., Christensen, K. K., Dohlmann, T. L., Larsen, Steen, Vigelsø, A. H., Dela, Flemming & Helge, Jørn Wulff, Apr 2018, In: Acta Physiologica (Print). 222, 4, e13009.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Effects of 6-month aerobic interval training on skeletal muscle metabolism in middle-aged metabolic syndrome patients

    Guadalupe-Grau, A., Fernández-Elías, V. E., Ortega, J. F., Dela, Flemming, Helge, Jørn Wulff & Mora-Rodriguez, R., Feb 2018, In: Scandinavian Journal of Medicine & Science in Sports. 28, 2, p. 585-595 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

    Gasbjerg, Lærke Smidt, Christensen, Mikkel Bring, Hartmann, Bolette, Lanng, A. R., wbf943, wbf943, Gabe, M. B. N., Dela, Flemming, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette & Knop, Filip Krag, Feb 2018, In: Diabetologia. 61, 2, p. 413-423

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Associations between vitamin D status and atherosclerosis among Inuit in Greenland

    Gjødesen, C. U., Jørgensen, M. E., Bjerregaard, P., Dahl-Petersen, I. K., Larsen, C. V. L., Noël, M., Melbye, M., Cohen, A. S., Lundqvist, M., Hougaard, D. M., Helge, Jørn Wulff & Nielsen, N. O., Jan 2018, In: Atherosclerosis. 268, p. 145-151 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Social Relations at Work and Incident Dementia: 29-Years' Follow-Up of the Copenhagen Male Study

    Ishtiak-Ahmed, K., Hansen, Åse Marie, Garde, A. H., Mortensen, Erik Lykke, Gyntelberg, F., Phung, T. K. T., Lund, Rikke, Rod, Naja Hulvej, Prescott, Eva, Waldemar, Gunhild, Westendorp, Rudi GJ & Nabe-Nielsen, Kirsten, Jan 2018, In: Journal of Occupational and Environmental Medicine. 60, 1, p. 12–18 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

    Morville, T., Rosenkilde, M., Mattsson, N., Dela, Flemming, Helge, Jørn Wulff & Rasmusen, Hanne K., 2018, In: Physician and Sportsmedicine. 46, 3, p. 263-268 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Bone mineral density in lifelong trained male football players compared with young and elderly untrained men

    Hagman, M., Helge, Eva Wulff, Hornstrup, T., Fristrup, B., Nielsen, Jens Jung, Jørgensen, N. R., Andersen, J. L., Helge, Jørn Wulff & Krustrup, P., 2018, In: Journal of Sport and Health Science. 7, 2, p. 159-168 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans

    Morville, T., Sahl, Ronni Eg, Trammell, Sam, Svenningsen, J. S., Gillum, M. P., Helge, Jørn Wulff & Clemmensen, Christoffer, 2018, In: JCI Insight. 3, 15, p. 1-13 e122737.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis

    Lundby, A. M., Jacobs, R. A., Gehrig, S., de Leur, J., Hauser, M., Bonne, T. C., Flück, D., Dandanell, S., Kirk, N., Kaech, A., Ziegler, U., Larsen, Steen & Lundby, C., 2018, In: Acta Physiologica (Print). 222, 1, 14 p., e12905.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Fitness and health benefits of team handball training for young untrained women - A cross-disciplinary RCT on physiological adaptations and motivational aspects

    Hornstrup, T., Wikman, J. M., Fristrup, B., Póvoas, S., Helge, Eva Wulff, Nielsen, S. H., Helge, Jørn Wulff, Andersen, J. L., Nybo, Lars & Krustrup, P., 2018, In: Journal of Sport and Health Science. 7, 2, p. 139-148 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Football training over 5 years is associated with preserved femoral bone mineral density in men with prostate cancer

    Uth, J., Fristrup, B., Haahr, R. D., Brasso, K., Helge, Jørn Wulff, Rørth, M. R., Midtgaard, Julie, Helge, Eva Wulff & Krustrup, P., 2018, In: Scandinavian Journal of Medicine & Science in Sports. 28, Suppl. 1, p. 61-73 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males

    Larsen, Steen, Lundby, A. M., Dandanell, S., Oberholzer, L., Keiser, S., Andersen, A. B., Haider, T. & Lundby, C., 2018, In: Physiological Reports. 6, 18, 9 p., e13793.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Hypertension treatment for older people-navigating between Scylla and Charybdis

    Conroy, S. P., Westendorp, Rudi GJ & Witham, M. D., 2018, In: Age and Ageing. 47, 4, p. 505-508 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

    Blum, M. R., Gencer, B., Adam, L., Feller, M., Collet, T., da Costa, B. R., Moutzouri, E., Dopheide, J., Depairon, M., Sykiotis, G. P., Kearney, P., Gussekloo, J., Westendorp, Rudi GJ, Stott, D. J., Bauer, D. C. & Rodondi, N., 2018, In: The Journal of clinical endocrinology and metabolism. 103, 8, p. 2988-2997 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Impact of Thyroid Hormone Therapy on Bone Health in Older Adults with Subclinical Hypothyroidism: a Randomized Clinical Trial

    Rodriguez, E. G., Lowe, A. L., Del Giovane, C., Feller, M., Kearney, P., Gussekloo, J., Mooijaart, S. P., Westendorp, Rudi GJ, Stott, D. J., Aeberli, D., Bauer, D., Hans, D. & Rodondi, N., 2018, In: Journal of Bone and Mineral Research. 33, p. 317-318 2 p., 1223.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  67. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Peak Fat Oxidation is Not Independently Related to Ironman Performance in Women

    Vest, S. D., Frandsen, J., Larsen, S., Dela, Flemming & Helge, Jørn Wulff, 2018, In: International Journal of Sports Medicine. 39, 12, p. 916-923

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Perturbations of NAD+ salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

    Andersen, M. A., Dall, M., Jensen, Benjamin Anderschou Holbech, Prats Gavalda, Clara, Madsen, S., Basse, A. L., Graae, A., Risis, S., Goldenbaum, J., Quistorff, B., Larsen, Steen, Vienberg, S. G. & Treebak, Jonas Thue, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 4, p. E377-E395 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Sarcopenia, Aging and Prospective Interventional Strategies

    Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In: Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  71. Published

    Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study

    Larsen, S., Vigelsø, A., Dandanell, S., Prats Gavalda, Clara, Dela, Flemming & Helge, Jørn Wulff, 2018, In: Journal of Diabetes Research. 2018, 7 p., 9257874 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    The added value of health indicators to mortality predictions in old age: A systematic review

    Kusumastuti, S., Rozing, Maarten Pieter, Lund, Rikke, Mortensen, Erik Lykke & Westendorp, Rudi GJ, 2018, In: European Journal of Internal Medicine. 57, p. 7-18 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  73. Published

    The dynamic life of the glycogen granule

    Prats Gavalda, Clara, Graham, T. E. & Shearer, J., 2018, In: Journal of Biological Chemistry. 293, 19, p. 7089-7098

    Research output: Contribution to journal › Review › Research › peer-review

  74. Published

    Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study

    van Vliet, N. A., Noordam, R., van Klinken, J. B., Westendorp, Rudi GJ, Bassett, J. D., Williams, G. R. & van Heemst, D., 2018, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 33, 7, p. 1318-1325 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. 2017
  76. Published

    When subclinical hypothyroidism becomes clinically diagnosed

    Nixon, M. & Westendorp, Rudi GJ, Dec 2017, In: European Journal of Internal Medicine. 46, p. e34-e35 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  77. Published

    Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

    Kristensen, M. D., Lund, M. T., Hansen, M., Poulsen, Steen Seier, Ploug, Thorkil, Dela, Flemming, Helge, Jørn Wulff & Prats Gavalda, Clara, Nov 2017, In: Obesity. 25, 11, p. 1921-1931 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  78. Published

    Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion

    van Opstal, A. M., Akintola, A. A., Elst, M. V. D., Westendorp, Rudi GJ, Pijl, H., van Heemst, D. & van der Grond, J., 17 Oct 2017, In: Scientific Reports. 7, p. 1-7 7 p., 13327.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

    Halling, Jens Frey, Jørgensen, Stine Ringholm, Olesen, J., Prats Gavalda, Clara & Pilegaard, Henriette, 1 Oct 2017, In: Experimental Gerontology. 96, p. 1-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Leydig cell dysfunction, systemic inflammation and metabolic syndrome in long-term testicular cancer survivors

    Bandak, M., Jørgensen, N., Juul, A., Lauritsen, J., Oturai, P. S., Mortensen, Jann, Hojman, P., Helge, Jørn Wulff & Daugaard, G., Oct 2017, In: European Journal of Cancer. 84, p. 9-17 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Thyroid status and mortality in nonagenarians from long-lived families and the general population

    van Vliet, N. A., van der Spoel, E., Beekman, M., Slagboom, P. E., Blauw, G. J., Gussekloo, J., Westendorp, Rudi GJ & van Heemst, D., Oct 2017, In: Aging. 9, 10, p. 2223—2234 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Bedside manners: How to deal with delirium

    Westendorp, Rudi GJ, Sep 2017, In: Cleveland Clinic Journal of Medicine. 84, 9, p. 699-700 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  83. Published

    Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids

    Rasmussen, J. J., Schou, Morten, Selmer, C., Johansen, M. L., Gustafsson, Finn, Frystyk, J., Dela, Flemming, Faber, Jens & Kistorp, Caroline Michaela Nervil, Sep 2017, In: Clinical Endocrinology. 87, 3, p. 249-256 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Raman probing of lipids, proteins, and mitochondria in skeletal myocytes: a case study on obesity

    Brazhe, N. A., Nikelshparg, E. I., Prats Gavalda, Clara, Dela, Flemming & Sosnovtseva, Olga, Sep 2017, In: Journal of Raman Spectroscopy. 48, 9, p. 1158-1165 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

    Asmar, M., Asmar, A., Simonsen, L., Gasbjerg, Lærke Smidt, wbf943, wbf943, Rosenkilde, Mette, Hartmann, Bolette, Dela, Flemming, Holst, Jens Juul & Bülow, J., Sep 2017, In: Diabetes. 66, 9, p. 2363-2371 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Thyroid function tests in the reference range and fracture: Individual participant analysis of prospective cohorts

    Aubert, C. E., Floriani, C., Bauer, D. C., da Costa, B. R., Segna, D., Blum, M. R., Collet, T-H., Fink, H. A., Cappola, A. R., Syrogiannouli, L., Peeters, R. P., Åsvold, B. O., den Elzen, W. P. J., Luben, R. N., Bremner, A. P., Gogakos, A., Eastell, R., Kearney, P. M., Hoff, M., Le Blanc, E. & 14 others, Ceresini, G., Rivadeneira, F., Uitterlinden, A. G., Khaw, K., Langhammer, A., Stott, D. J., Westendorp, Rudi GJ, Ferrucci, L., Williams, G. R., Gussekloo, J., Walsh, J. P., Aujesky, D., Rodondi, N. & Thyroid Studies Collaboration, T. S. C., 1 Aug 2017, In: The Journal of clinical endocrinology and metabolism. 102, 8, p. 2719–2728 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    DNA polymerase beta participates in mitochondrial DNA repair

    Sykora, P., Kanno, S., Akbari, M., Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In: Molecular and Cellular Biology. 37, 16, e00237-17.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Effect of APOE ε4 allele on survival and fertility in an adverse environment

    van Exel, E., Koopman, J. J. E., Bodegom, D. V., Meij, J. J., Knijff, P. D., Ziem, J. B., Finch, C. E. & Westendorp, Rudi GJ, 6 Jul 2017, In: PLOS ONE. 12, 7, p. 1-13 13 p., e0179497.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    A randomized double-blind study of testosterone replacement therapy or placebo in testicular cancer survivors with mild Leydig cell insufficiency (Einstein-intervention)

    Bandak, M., Jørgensen, N., Juul, Anders, Lauritsen, J., Kreiberg, M., Oturai, P. S., Helge, Jørn Wulff & Daugaard, G., 3 Jul 2017, In: B M C Cancer. 17, 8 p., 461.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study

    Kusumastuti, S., Gerds, Thomas Alexander, Lund, Rikke, Mortensen, Erik Lykke & Westendorp, Rudi GJ, Jul 2017, In: European Journal of Internal Medicine. 42, p. 29-38 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Influence of maximal fat oxidation on long-term weight loss maintenance in humans

    Dandanell, S., Husted, Karina Louise Skov, Amdisen, S., Vigelso, A., Dela, Flemming, Larsen, Steen & Helge, Jørn Wulff, Jul 2017, In: Journal of Applied Physiology. 123, 1, p. 267-274 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers

    Bandak, M., Jorgensen, N., Juul, Anders, Lauritsen, J., Kier, M. G. G., Mortensen, M. S., Oturai, P. S., Mortensen, Jann, Hojman, P., Helge, Jørn Wulff & Daugaard, G., Jul 2017, In: Andrology. 5, 4, p. 718-724 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Is there evidence for a limit to human lifespan?

    Rozing, Maarten Pieter, Kirkwood, T. B. L. & Westendorp, Rudi GJ, 29 Jun 2017, In: Nature. 546, 7660, p. E11-E12 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  94. Published

    Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism

    Stott, D. J., Rodondi, N., Kearney, P. M., Ford, I., Westendorp, R. G. J., Mooijaart, S. P., Sattar, N., Aubert, C. E., Aujesky, D., Bauer, D. C., Baumgartner, C., Blum, M. R., Browne, J. P., Byrne, S. L., Collet, T-H., Dekkers, O. M., den Elzen, W. P. J., Du Puy, R. S., Ellis, G., Feller, M. & 27 others, Floriani, C., Hendry, K., Hurley, C., Jukema, J. W., Kean, S., Kelly, M., Krebs, D., Langhorne, P., McCarthy, G., McCarthy, V., McConnachie, A., McDade, M., Messow, M., O’Flynn, A., O’Riordan, D., Poortvliet, R. K. E., Quinn, T. J., Russell, A., Sinnott, C., Smit, J. W. A., Van Dorland, H. A., Walsh, K. A., Walsh, E. K., Watt, T., Wilson, R., Gussekloo, J. & the TRUST Study Group, T. T. S. G., 29 Jun 2017, In: New England Journal of Medicine. 376, 26, p. 2534-2544 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

    Sahl, Ronni Eg, Andersen, P. R., Gronbaek, K., Morville, T. H., Rosenkilde, M., Rasmusen, H. K., Poulsen, Steen Seier, Prats Gavalda, Clara, Dela, Flemming & Helge, Jørn Wulff, 22 Jun 2017, In: Frontiers in Physiology. 8, 6 p., 407.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study

    Asping, M., Stride, N., Sogaard, D., Dohlmann, T. L., Helge, Jørn Wulff, Dela, Flemming & Larsen, S., Jun 2017, In: European Journal of Clinical Pharmacology. 73, 6, p. 679-687

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    A high carbohydrate diet remains the evidence based choice for elite athletes to optimise performance

    Helge, Jørn Wulff, 1 May 2017, In: Journal of Physiology. 595, 9, p. 2775-2775

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  98. Published

    Is there plasticity in mitochondrial cristae density with endurance training?

    Larsen, Steen, Helge, Jørn Wulff & Dela, Flemming, 1 May 2017, In: Journal of Physiology. 595, 9, p. 2985-2985 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  99. Published

    How is Change in Physical Health Status Reflected by Reports of Nurses and Older People Themselves?

    Puvill, T., Lindenberg, J., Slaets, J. P. J., de Craen, A. J. M. & Westendorp, Rudi GJ, 1 Apr 2017, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 72, 4, p. 579–585 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Determination of the exercise intensity that elicits maximal fat oxidation in individuals with obesity

    Jørgensen, S. D., Præst, C. B., Søndergård, S. D., Skovborg, C., Dela, Flemming, Larsen, Steen & Helge, Jørn Wulff, Apr 2017, In: Applied Physiology, Nutrition and Metabolism. 42, 4, p. 405-412 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  101. Published

    Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

    Jørgensen, S. D., Skovborg, C., Præst, C. B., Kristensen, K. B., Nielsen, M. G., Lionett, S., Jørgensen, S. D., Vigelsø Hansen, A., Dela, Flemming & Helge, Jørn Wulff, Apr 2017, In: Obesity Research & Clinical Practice. 11, 4, p. 489-498 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. Published

    Effect of intranasally administered insulin on cerebral blood flow and perfusion: a randomized experiment in young and older adults

    Akintola, A. A., van Opstal, A. M., Westendorp, Rudi GJ, Postmus, I., van der Grond, J. & van Heemst, D., 14 Mar 2017, In: Aging. 9, 3, p. 790-802 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    Being Active, Engaged, and Healthy: Older Persons' Plans and Wishes to Age Successfully

    Huijg, J. M., van Delden, A. (. E. Q., van der Ouderaa, F. J. G., Westendorp, Rudi GJ, Slaets, J. P. J. & Lindenberg, J., 1 Mar 2017, In: Journals of Gerontology. Series B: Psychological Sciences & Social Sciences. 72, 2, p. 228-236 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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