Damage and Repair

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  1. 2017
  2. Published

    Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

    Munk, S., Sigurðsson, J. O., Xiao, Z., Batth, Tanveer Singh, Franciosa, Giulia, von Stechow, L., Lopez-Contreras, Andres, Vertegaal, A. C. O. & Olsen, Jesper Velgaard, 2017, In: Cell Reports. 21, 2, p. 546-558 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Desler, Claus, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, L. H. & Rasmussen, Lene Juel, 2017, In: Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

    Eliasson, P., Svensson, R. B., Giannopoulos, A., Eismark, C., Kjær, Michael, Schjerling, P. & Heinemeier, K. M., 2017, In: PLOS ONE. 12, 3, 16 p., e0172797.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Stalled replication forks generate a distinct mutational signature in yeast

    Larsen, N. B., Liberti, S. E., Vogel, Ivan, Jorgensen, S. W., Hickson, Ian David & Mankouri, H. W., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. 9665-9670

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Sub-Clinical Cognitive Decline and Resting Cerebral Blood Flow in Middle Aged Men

    Henriksen, O. M., Hansen, N. L., Osler, Merete, Mortensen, Erik Lykke, Hallam, D. M., Pedersen, E. T., Chappell, M., Lauritzen, Martin & Rostrup, E., 2017, In: PLOS ONE. 12, 1, 15 p., e0169912.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The "enemies within": regions of the genome that are inherently difficult to replicate

    Bhowmick, Rahul & Hickson, Ian David, 2017, In: F1000Research. 6, 7 p., 666.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    The breaking and making of healthy adult human skeletal muscle in vivo

    Mackey, Abigail & Kjær, Michael, 2017, In: Skeletal Muscle. 7, 18 p., 24.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In: Scientific Reports. 7, 46208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Visual steady state in relation to age and cognitive function

    Horwitz, A., Dyhr Thomsen, M., Wiegand, I., Horwitz, H., Klemp, Marc Patrick Brag, Nikolic, M., Rask, L., Lauritzen, Martin & Benedek, Krisztina, 2017, In: PLOS ONE. 12, 2, 23 p., e0171859.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2016
  12. Published

    RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

    Bhowmick, Rahul, Minocherhomji, S. & Hickson, Ian David, 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1117-1126 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Cognitive Change during the Life Course and Leukocyte Telomere Length in Late Middle-Aged Men

    Rask, L., Bendix, L., Harbo, M., Fagerlund, Birgitte, Mortensen, Erik Lykke, Lauritzen, Martin & Osler, Merete, 9 Dec 2016, In: Frontiers in Aging Neuroscience. 8, 7 p., 300.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Effect of aging and exercise on the tendon

    Svensson, R. B., Heinemeier, K. M., Couppé, Christian, Kjær, Michael & Magnusson, Stig Peter, 1 Dec 2016, In: Journal of Applied Physiology. 121, 6, p. 1237-1246 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

    Marosi, K., Kim, S. W., Moehl, K., Scheibye-Knudsen, Morten, Cheng, A., Cutler, R., Camandola, S. & Mattson, M. P., Dec 2016, In: Journal of Neurochemistry. 139, 5, p. 769-781 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression

    Syed, S., Desler, Claus, Rasmussen, Lene Juel & Schmidt, K. H., Dec 2016, In: P L o S Genetics. 12, 12, 28 p., e1006451.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

    Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, L. H., Dec 2016, In: Neurobiology of Aging. 48, p. 34-47

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In: Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Isometric abdominal wall muscle strength assessment in individuals with incisional hernia: a prospective reliability study

    Jensen, K. K., Kjær, Michael & Jørgensen, Lars Nannestad, Dec 2016, In: Hernia. 20, 6, p. 831-837

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study)

    Eriksen, C. S., Garde, Ellen, Reislev, N. L., Wimmelmann, Cathrine Lawaetz, Bieler, T., Ziegler, A. K., Gylling, A. T., Dideriksen, K. J., Siebner, Hartwig Roman, Mortensen, Erik Lykke & Kjær, Michael, Dec 2016, In: B M J Open. 6, 12, p. 1-13 13 p., e012951.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

    Herrtwich, L., Nanda, I., Evangelou, K., Nikolova, T., Horn, V., Sagar, Erny, D., Stefanowski, J., Rogell, L., Klein, C., Gharun, K., Follo, M., Seidl, M., Kremer, B., Muenke, N., Senges, J., Fliegauf, M., Aschman, T., Pfeifer, D., Sarrazin, S. & 18 others, Sieweke, M. H., Wagner, D., Dierks, C., Haaf, T., Ness, T., Zaiss, M. M., Voll, R. E., Deshmukh, S. D., Prinz, M., Goldmann, T., Hoelscher, C., Hauser, A. E., Lopez-Contreras, Andres, Gruen, D., Gorgoulis, V., Diefenbach, A., Henneke, P. & Triantafyllopoulou, A., 17 Nov 2016, In: Cell. 167, 5, p. 1264–1280.e18

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

    Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N. & 1 others, Bekker-Jensen, Simon Holst, 7 Nov 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366

    Research output: Contribution to journal › Letter › Research › peer-review

  23. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

    Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J. & 2 others, Gorospe, M. & Bohr, Vilhelm, 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Activation of the ATR kinase by the RPA-binding protein ETAA1

    Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Neurodegeneration in Accelerated Aging

    Scheibye-Knudsen, Morten, Nov 2016, In: Danish Medical Journal. 63, 11, 21 p., B5308.

    Research output: Contribution to journal › Review › Research › peer-review

  26. Published

    PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction

    Nielsen, Christian Friberg & Hickson, Ian David, 17 Oct 2016, In: Cell Cycle. 15, 20, p. 2704-2711 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P. & 2 others, Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In: Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

    Ghamrasni, S. E., Cardoso, R., Li, L., Guturi, K. K. N., Bjerregaard, Victoria Alexandra, Liu, Ying, Venkatesan, S., Hande, M. P., Henderson, J. T., Sanchez, O., Hickson, Ian David, Hakem, A. & Hakem, R., 15 Sep 2016, In: Oncogene. 35, 37, p. 4836-4845 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    In response: Gamma oscillations or spikes?

    Benedek, Krisztina & Lauritzen, Martin, Sep 2016, In: Epilepsia. 57, 9, p. 1524–1525 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  30. Published

    Ruptured human Achilles tendon has elevated metabolic activity up to 1 year after repair

    Eliasson, P., Couppé, C., Lonsdale, M., Svensson, R. B., Neergaard, C., Kjær, Michael, Friberg, L. & Magnusson, Stig Peter, Sep 2016, In: European Journal of Nuclear Medicine and Molecular Imaging. 43, 10, p. 1868-77 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication

    Dideriksen, K., Boesen, A. P., Kristiansen, J. F., Magnusson, Stig Peter, Schjerling, Peter, Holm, L. & Kjær, Michael, Sep 2016, In: Experimental Gerontology. 82, p. 8-18 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Efficacy of ATR inhibitors as single agents in Ewing sarcoma

    Nieto-Soler, M., Morgado-Palacin, I., Lafarga, V., Lecona, E., Murga, M., Callen, E., Azorin, D., Alonso, J., Lopez-Contreras, Andres, Nussenzweig, A. & Fernandez-Capetillo, O., 26 Aug 2016, In: OncoTarget. 7, 37, p. 58759-58767

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Exonuclease 1 and its versatile roles in DNA repair

    Keijzers, G., Liu, D. & Rasmussen, Lene Juel, 5 Aug 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 440–451 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Activity-Dependent Calcium, Oxygen, and Vascular Responses in a Mouse Model of Familial Hemiplegic Migraine Type 1

    Khennouf, Lila, Gesslein, B., Lind, Barbara Lykke, van den Maagdenberg, A. M. J. M. & Lauritzen, Martin, Aug 2016, In: Annals of Neurology. 80, 2, p. 219-232

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

    Pitchai, G. P., Hickson, Ian David, Streicher, W., Montoya, Guillermo & Mesa, Pablo, Aug 2016, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 72, 8, p. 646-651 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Sex Hormones and Tendon

    Hansen, M. & Kjær, Michael, Aug 2016, Metabolic influences on risk for tendon disorders. Springer, Vol. 920. p. 139-149 11 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  37. Published

    Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage

    Heinemeier, K. M., Schjerling, P., Heinemeier, J., Møller, M. B., Krogsgaard, Michael R., Grum-Schwensen, T., Petersen, Michael Mørk & Kjær, Michael, 6 Jul 2016, In: Science Translational Medicine. 8, 346, 346ra90.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In: Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    No additional effect of different types of physical activity on 10-hour muscle protein synthesis in elderly men on a controlled energy- and protein-sufficient diet

    Bulow, J., Agergaard, J., Kjær, Michael, Holm, L. & Reitelseder, S., 15 Jun 2016, In: Experimental Gerontology. 79, p. 16-25

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

    Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., Gonzalez-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Buron, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C. & 27 others, Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & de Cabo, R., 14 Jun 2016, In: Cell Metabolism. 23, 6, p. 1093-1112

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO

    Diehl, C., Akke, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Streicher, W. & Wikström, M., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease

    Kolko, Miriam, Vosborg, F., Henriksen, J. U. L., Hasan-Olive, M. M., Diget, E. H., Vohra, Rupali, Gurubaran, I. S., Gjedde, Albert, Mariga, S. T., Jensen, Dorte Skytt, Utheim, T. P., Storm-Mathisen, J. & Bergersen, L. H., 1 Jun 2016, In: Neurochemical Research. 41, 6, p. 1229-1236

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    ATP induce intracellular calcium rises in cultures of primary brain pericytes

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  46. Published

    Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

    Schwertman, P., Bekker-Jensen, Simon Holst & Mailand, Niels, Jun 2016, In: Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression

    Heinemeier, K. M., Lorentzen, M. P., Kildevang Jensen, J., Schjerling, P., Sennes, O., Narici, M. & Kjær, Michael, 1 May 2016, In: Journal of Applied Physiology. 120, 9, p. 1000-1010 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Neocortical gamma oscillations in idiopathic generalized epilepsy

    Benedek, K., Berenyi, A., Gombkoto, P., Piilgaard, H. & Lauritzen, Martin, May 2016, In: Epilepsia. 57, 5, p. 796-804 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation

    Toft-Kehler, A. K., Gurubaran, I. S., Desler, Claus, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In: Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    USP7 is a SUMO deubiquitinase essential for DNA replication

    Lecona, E., Rodriguez-Acebes, S., Specks, J., Lopez-Contreras, Andres, Ruppen, I., Murga, M., Muñoz, J., Mendez, J. & Fernandez-Capetillo, O., 23 Apr 2016, In: Nature Structural and Molecular Biology. 23, 4, p. 270-277 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication

    Mackey, Abigail, Rasmussen, L. K., Kadi, F., Schjerling, Peter, Helmark, I. C., Ponsot, E., Aagaard, P., Durigan, J. L. Q. & Kjær, Michael, 2 Mar 2016, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30, 6, p. 2266-2281

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1: High fat diet in schizophrenia mouse model

    Holm-hansen, S., Low, J. K., Zieba, J., Gjedde, Albert, Bergersen, L. H. & Karl, T., 1 Mar 2016, In: Genes, Brain and Behavior. 15, 3, p. 295-304

    Research output: Contribution to journal › Journal article › Research › peer-review

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