Damage and Repair

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  1. 2020
  2. Published

    Protecting the Aging Genome

    Petr, Michael Angelo, Tulika, T., Carmona Marin, Lina Maria & Scheibye-Knudsen, Morten, 2020, In: Trends in Cell Biology. 30, 2, p. 117-132 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts

    Yeung, C. C., Schoof, E. M., Tamáš, M., Mackey, Abigail & Kjær, Michael, 2020, In: Cell Communication and Signaling. 18, 1, 15 p., 177.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

    Wu, Wei, Bhowmick, Rahul, Vogel, Ivan, Özer, Ö., Ghisays, F., Thakur, R. S., Sanchez de Leon, E., Richter, P. H., Ren, L., Petrini, J. H., Hickson, Ian David & Liu, Ying, 2020, In: Nature Structural & Molecular Biology. 27, 5, p. 424-437 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Regional collagen turnover and composition of the human patellar tendon

    Zhang, C., Couppé, Christian, Scheijen, J. L. J. M., Schalkwijk, C. G., Kjær, Michael, Magnusson, Stig Peter & Svensson, R. B., 2020, In: Journal of Applied Physiology. 128, 4, p. 884-891

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Regional differences in turnover, composition, and mechanics of the porcine flexor tendon

    Zhang, C., Svensson, R. B., Couppé, Christian, Schjerling, P., Skovgaard, D., Kjær, Michael & Magnusson, Stig Peter, 2020, In: Connective Tissue Research. 61, 5, p. 475-484

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

    Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Ying, Hickson, Ian David, Shen, H. & Ying, S., 2020, In: Molecular Cell. 78, 4, p. 714-724.e5

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

    Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., Wong, H. S., Gibbs, E., Iyer, S. S., Basisty, N., Wu, Q., Kim, I. J., Silva, E., Vitangcol, K., Shin, K. O., Lee, Y. M. & 11 others, Riley, R., Ben-Sahra, I., Ott, M., Schilling, B., Scheibye-Knudsen, Morten, Ishihara, K., Quake, S. R., Newman, J., Brenner, C., Campisi, J. & Verdin, E., 2020, In: Nature Metabolism. 2, 11, p. 1265-1283 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

    Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Desler, Claus, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In: iScience. 23, 10, 42 p., 101556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Supraphysiological protection from replication stress does not extend mammalian lifespan

    Albers, E., Avram, Alexandra Ioana, Sbroggio, M., Fernandez-Capetillo, O. & Lopez-Contreras, Andres, 2020, In: Aging. 12, 7, p. 5612-5624 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    TIP60 in aging and neurodegeneration

    Li, Zhiquan & Rasmussen, Lene Juel, 2020, In: Ageing Research Reviews. 64, 101195.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In: Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

    Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Bagge, Keerthana Stine Viswalingam, Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Ellegaard, M., Bieler, T., Beyer, N., Kjær, Michael & Jørgensen, Niklas Rye, 2020, In: Translational Sports Medicine. 3, 1, p. 16-25

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Gylling, A. T., Eriksen, C. S., Garde, Ellen, Wimmelmann, Cathrine Lawaetz, Reislev, N. L., Bieler, T., Ziegler, A. K., Andersen, K. W., Bauer, C., Dideriksen, K., Bækgaard, M., Mertz, K. H., Bayer, M. L., Bloch-Ibenfeldt, M., Boraxbekk, CJ, Siebner, Hartwig Roman, Mortensen, Erik Lykke & Kjær, Michael, 2020, In: Experimental Gerontology. 136, 110939.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The many lives of type IA topoisomerases

    Bizard, A. H. & Hickson, Ian David, 2020, In: Journal of Biological Chemistry. 295, 20, p. 7138-7153 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

    Wu, Wei, Hickson, Ian David & Liu, Ying, 2020, In: Genome Instability & Disease. 1, 3, p. 114–128 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Tumour predisposition and cancer syndromes as models to study gene–environment interactions

    Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, Petrini, J. H., Schmidt, L. S. & Yang, H., 2020, In: Nature Reviews Cancer. 20, p. 533–549

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, In: Genetics in Medicine. 22, p. 847–856

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2019
  22. Published

    The influence of fibrillin‐1 and physical activity upon tendon tissue morphology and mechanical properties in mice

    Tran, P. H. T., Skrba, T., Wondimu, E., Galatioto, G., Svensson, R. B., Olesen, A. T., Mackey, Abigail, Magnusson, Stig Peter, Ramirez, F. & Kjær, Michael, 1 Nov 2019, In: Physiological Reports. 7, 21, 9 p., e14267 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Influence of Oral Contraceptive Use on Adaptations to Resistance Training

    Dalgaard, L. B., Dalgas, U., Andersen, J. L., Rossen, N. B., Moller, A. B., Stodkilde-Jorgensen, H., Jorgensen, J. O., Kovanen, V., Couppe, C., Langberg, Henning, Kjær, Michael & Hansen, M., Jul 2019, In: Frontiers in Physiology. 10, 14 p., 824.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure

    Hjerrild, J. N., Wobbe, A., Stausholm, M. B., Larsen, A. E., Josefsen, C. O., Malmgaard-Clausen, N. M., Dela, Flemming, Kjær, Michael, Magnusson, Stig Peter, Hansen, M., Svensson, R. B. & Couppé, C., 22 Jun 2019, In: Nutrients. 11, 6

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Immobilization Decreases FOXO3a Phosphorylation and Increases Autophagy-Related Gene and Protein Expression in Human Skeletal Muscle

    Møller, A. B., Vendelbo, M. H., Schjerling, Peter, Couppé, Christian, Møller, N., Kjær, Michael, Hansen, M. & Jessen, N., 14 Jun 2019, In: Frontiers in Physiology. 10, 14 p., 736.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and non-myogenic cells derived from human skeletal muscle

    Bechshøft, C. J. L., Jensen, S. M., Schjerling, P., Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, Jun 2019, In: American Journal of Physiology: Cell Physiology. 316, 6, p. C898-C912

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Lactate-Mediated Protection of Retinal Ganglion Cells

    Vohra, Rupali, Aldana, Blanca, Bulli, G., Jensen, Dorte Skytt, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1878-1888 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with resistance training in 83-94-year-old men and women

    Karlsen, Anders, Bechshøft, R. L., Malmgaard-Clausen, N. M., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 3 Mar 2019, In: Acta Physiologica. 227, ja, e13271.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

    Vohra, Rupali, Aldana, Blanca, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 1 Mar 2019, In: Investigative Ophthalmology & Visual Science. 60, 4, p. 999-1008 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Behandling af akutte muskelskader

    Bayer, M. L., Mackey, Abigail, Magnusson, Stig Peter, Krogsgaard, Michael R. & Kjær, Michael, 18 Feb 2019, In: Ugeskrift for Laeger. 181, 8, 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Potential metabolic markers in glaucoma and their regulation in response to hypoxia

    Vohra, Rupali, Dalgaard, L. M., Vibaek, J., Langbøl, Mia Aggergaard, Bergersen, L. H., Olsen, N. V., Hassel, B., Chaudhry, F. A. & Kolko, Miriam, 28 Jan 2019, In: Acta Ophthalmologica. 97, 6, p. 567-576

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

    Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, L. H., 2019, In: Neurochemical Research. 44, 1, p. 22-37 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    A defined human aging phenome

    Andreassen, Søren Norge, Ben Ezra, Michael & Scheibye-Knudsen, Morten, 2019, In: Aging. 11, 15, p. 5786-5806 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, G., Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, L. J., Greenblatt, M. S. & 2 others, de Wind, N. & Tavtigian, S. V., 2019, In: Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Altered alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD)

    Medin, T., Jensen, V., Skare, O., Storm-Mathisen, J., Hvalby, O. & Bergersen, L. H., 2019, In: Behavioural Brain Research. 360, p. 209-215 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Ziegler, A. K., Damgaard, A., Mackey, Abigail, Schjerling, Peter, Magnusson, Stig Peter, Olesen, A. T., Kjær, Michael & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p., 12069.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Artificial intelligence for aging and longevity research: Recent advances and perspectives

    Zhavoronkov, A., Mamoshina, P., Vanhaelen, Q., Scheibye-Knudsen, Morten, Moskalev, A. & Aliper, A., 2019, In: Ageing Research Reviews. 49, p. 49-66 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  38. Published

    Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

    Mamoshina, P., Kochetov, K., Cortese, F., Kovalchuk, A., Aliper, A., Putin, E., Scheibye-Knudsen, Morten, Cantor, C. R., Skjodt, N. M., Kovalchuk, O. & Zhavoronkov, A., 2019, In: Scientific Reports. 9, 10 p., 142.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Brain Responses to Passive Sensory Stimulation Correlate With Intelligence

    Horwitz, A., Klemp, Marc Patrick Brag, Horwitz, Henrik, Thomsen, M. D., Rostrup, Egill, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin & Benedek, K., 2019, In: Frontiers in Aging Neuroscience. 11, 17 p., 201.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Chromosome instability syndromes

    Taylor, A. M. R., Rothblum-Oviatt, C., Ellis, N. A., Hickson, Ian David, Meyer, S., Crawford, T. O., Smogorzewska, A., Pietrucha, B., Weemaes, C. & Stewart, G. S., 2019, In: Nature Reviews. Disease Primers. 5, 20 p., 64.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Copenhagen Consensus statement 2019: Physical activity and ageing

    Bangsbo, J., Blackwell, J., Boraxbekk, C-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjær, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., Skinner, T. & 6 others, Skovgaard, T., Troelsen, J., Tulle, E., Tully, M. A., van Uffelen, J. G. Z. & Viña, J., 2019, In: British Journal of Sports Medicine. 53, 14, p. 856-858 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Corticosteroid injection is the best treatment in plantar fasciitis if combined with controlled training

    Johannsen, F. E., Herzog, R. B., Malmgaard-Clausen, N. M., Hoegberget-Kalisz, M., Magnusson, Stig Peter & Kjær, Michael, 2019, In: Knee Surgery, Sports Traumatology, Arthroscopy. 27, 1, p. 5-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    DNA replication stress and its impact on chromosome segregation and tumorigenesis

    Zhang, B. N., Bueno Venegas, A., Hickson, Ian David & Chu, W. K., 2019, In: Seminars in Cancer Biology. 55, p. 61-69

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Esc2 promotes telomere stability in response to DNA replication stress

    Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    From powerhouse to perpetrator—mitochondria in health and disease

    Fakouri, N. B., Hansen, T. L., Desler, Claus, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In: Biology. 8, 2, 15 p., 35.

    Research output: Contribution to journal › Review › Research › peer-review

  46. Published

    High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes

    Baekkerud, F. H., Salerno, S., Ceriotti, P., Morland, C., Storm-Mathisen, J., Bergersen, L. H., Hoydal, M. A., Catalucci, D. & Stolen, T. O., 2019, In: Cardiovascular Toxicology. 19, 5, p. 422-431 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

    Keijzers, G., Bakula, Daniela Janina, Petr, Michael Angelo, Madsen, N. G. K., Teklu, Amanuel Abraha, Mkrtchyan, Garik, Osborne, Brenna & Scheibye-Knudsen, Morten, 2019, In: International Journal of Molecular Sciences . 20, 1, 15 p., 74.

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Integrated method for quantitative morphometry and oxygen transport modeling in striated muscle

    Al-Shammari, A. A., Kissane, R. W. P., Holbek, S., Mackey, Abigail, Andersen, T. R., Gaffney, E. A., Kjær, Michael & Egginton, S., 2019, In: Journal of Applied Physiology. 126, 3, p. 544-557 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Latest advances in aging research and drug discovery

    Bakula, D., Ablasser, A., Aguzzi, A., Antebi, A., Barzilai, N., Bittner, M. I., Jensen, M. B., Calkhoven, C. F., Chen, D., de Grey, A. D. N. J., Feige, J. N., Georgievskaya, A., Gladyshev, V. N., Golato, T., Gudkov, A. V., Hoppe, T., Kaeberlein, M., Katajisto, P., Kennedy, B. K., Lal, U. & 10 others, Martin-Villalba, A., Moskalev, A. A., Ozerov, I., Petr, Michael Angelo, Reason, Rubinsztein, D. C., Tyshkovskiy, A., Vanhaelen, Q., Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2019, In: Aging. 11, 22, p. 9971-9981 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells

    Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Desler, Claus & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells

    Lauridsen, P. E., Rasmussen, Lene Juel & Desler, Claus, 2019, In: Mitochondrion. 47, p. 47-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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