Damage and Repair

  1. 2015
  2. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well-treated rheumatoid arthritis patients

    Mikkelsen, U. R., Dideriksen, K., Andersen, M. B., Boesen, A., Malmgaard-Clausen, N. M., Sørensen, I. J., Schjerling, Peter, Kjær, Michael & Holm, L., 2015, In: Arthritis Research & Therapy (Print). 17, p. 271

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Replication stress activates DNA repair synthesis in mitosis

    Minocherhomji, S., Ying, S., Bjerregaard, Victoria Alexandra, Bursomanno, S., Aleliunaite, A., Wu, Wei, Mankouri, H. W., Shen, H., Liu, Ying & Hickson, Ian David, 10 Dec 2015, In: Nature. 528, 7581, p. 286-90 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  5. Published

    The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

    Morland, C., Lauritzen, K. H., Puchades, M., Holm-Hansen, S., Andersson, K., Gjedde, Albert, Attramadal, H., Storm-Mathisen, J. & Bergersen, L. H., Jul 2015, In: Journal of Neuroscience Research. 93, 7, p. 1045-1055 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

    Newman, J. A., Savitsky, P., Allerston, C. K., Bizard, A. H., Özer, Ö., Sarlós, K., Liu, Ying, Pardon, E., Steyaert, J., Hickson, Ian David & Gileadi, O., 2015, In: Nucleic Acids Research. 43, 10, p. 5221-35 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

    Nielsen, Christian Friberg, Huttner, D., Bizard, A. H., Hirano, S., Li, T., Palmai-Pallag, T., Bjerregaard, Victoria Alexandra, Liu, Ying, Nigg, E. A., Wang, L. H. & Hickson, Ian David, 2015, In: Nature Communications. 6, 15 p., 8962.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway

    Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In: E M B O Journal. 34, p. 1385-1398

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Astrocytes gate synaptic transmission from unmyelinated sensory afferents

    Perrier, Jean-Francois Marie, Christensen, R. K., Delgado-Lezama, R., Russo, R., Lind, Barbara Lykke, Alcocer, E. L., Fabbiani, G., Schmitt, Nicole, Lauritzen, Martin, Petersen, A. V. & Carlsen, E. M., Aug 2015, In: Glia. 63, S1, p. E241-E241 T08-22B .

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  10. Published

    Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells

    Ramos-Molina, B., Lopez-Contreras, Andres, Lambertos, A., Dardonville, C., Cremades, A. & Peñafiel, R., 2015, In: Amino Acids. 47, 5, p. 1025-34 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The challenges of human population ageing

    Sander, M., Oxlund, Bjarke, Jespersen, Astrid Pernille, Krasnik, Allan, Mortensen, Erik Lykke, Westendorp, Rudi GJ & Rasmussen, Lene Juel, Mar 2015, In: Age and Ageing. 44, 2, p. 185-7 3 p.

    Research output: Contribution to journalJournal articleCommunication

  12. Published

    A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development

    Specks, J., Lecona, E., Lopez-Contreras, Andres & Fernandez-Capetillo, O., Sep 2015, In: Molecular and Cellular Biology. 35, 17, p. 2910-2917 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Centriolar satellites: key mediators of centrosome functions

    Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

    Tollenaere, M. A. X., Villumsen, B. H., Blasius, M., Nielsen, J. C., Wagner, S. A., Bartek, J., Beli, P., Mailand, Niels & Bekker-Jensen, Simon Holst, 30 Nov 2015, In: Nature Communications. 6, p. 1-12 12 p., 10075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

    Xing, M., Wang, X., Palmai-Pallag, T., Shen, H., Helleday, T., Hickson, Ian David & Ying, S., 2015, In: OncoTarget. 6, 35, p. 37638-37646 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2014
  18. Published

    Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling

    Airik, R., Slaats, G. G., Guo, Z., Weiss, A., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R. H. & Hildebrandt, F., Nov 2014, In: Journal of the American Society of Nephrology:JASN. 25, 11, p. 2573-83 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, M., Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Desler, Claus, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In: DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Bengt Saltin (1935-2014)

    Bangsbo, Jens, Kjær, Michael & Hellsten, Ylva, 2014, In: Journal of Physiology. 592, 23, p. 5149-5151 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype

    Bayer, M. L., Schjerling, Peter, Herchenhan, A., Zeltz, C., Heinemeier, K. M., Christensen, L., Krogsgaard, Michael R., Gullberg, D. & Kjær, Michael, 2014, In: PLOS ONE. 9, 1, p. 1-16 16 p., e86078.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Dissolution of Double Holliday Junctions

    Bizard, A. H. & Hickson, Ian David, 1 Jul 2014, In: Cold Spring Harbor perspectives in biology. 6, p. 1-16 16 p., a016477.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1

    Bocquet, N., Bizard, A. H., Abdulrahman, W., Larsen, N. B., Faty, M., Cavadini, S., Bunker, R. D., Kowalczykowski, S. C., Cejka, P., Hickson, Ian David & Thomä, N. H., Mar 2014, In: Nature Structural and Molecular Biology. 21, 3, p. 261-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Effect of growth hormone on aging connective tissue in muscle and tendon - gene expression, morphology and function following immobilization and rehabilitation

    Boesen, A. P., Dideriksen, K. J., Couppé, Christian, Magnusson, Stig Peter, Schjerling, Peter, Boesen, M., Aagaard, P., Kjær, Michael & Langberg, Henning, 2014, In: Journal of Applied Physiology. 116, p. 192-203 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Multiscale vision model for event detection and reconstruction in two-photon imaging data

    Brazhe, A., Mathiesen, C., Lind, Barbara Lykke, Rubin, A. & Lauritzen, Martin, Jul 2014, In: Neurophotonics. 1, 1, 011012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

    Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, Ian David, Gileadi, O. & Rothenberg, E., 24 Nov 2014, In: Nature Communications. 5, p. 1-12 12 p., 5556.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Accuracy of MRI technique in measuring tendon cross-sectional area

    Couppé, Christian, Svensson, R. B., Elbrønd (Bibs), Vibeke Sødring, Hansen, P., Kjær, Michael & Magnusson, Stig Peter, 2014, In: Clinical Physiology and Functional Imaging. 34, 3, p. 237-241 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue

    Couppé, Christian, Svensson, R. B., Grosset, J., Kovanen, V., Nielsen, R. H., Olsen, M. R., Larsen, J. O., Praet, S. F. E., Skovgaard, D., Hansen, M., Aagaard, P., Kjær, Michael & Magnusson, Stig Peter, Aug 2014, In: Age (Dordrecht, Netherlands). 36, 4, p. 1-19 19 p., 9665.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In: Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Capillary pericytes regulate cerebral blood flow in health and disease

    Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O'Farrell, F. M., Buchan, A. M., Lauritzen, Martin & Attwell, D., Apr 2014, In: Nature. 508, 7494, p. 55-60 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Basic Components of Connective Tissues and Extracellular Matrix: Elastin, Fibrillin, Fibulins, Fibrinogen, Fibronectin, Laminin, Tenascins and Thrombospondins

    Halper, J. & Kjær, Michael, 2014, Progress in Heritable Soft Connective Tissue Diseases. Vol. 802. p. 31-47 17 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  33. Published

    Influence of Sex and Estrogen on Musculotendinous Protein Turnover at Rest and After Exercise

    Hansen, M. & Kjær, Michael, 2014, In: Exercise and Sport Sciences Reviews. 42, 4, p. 183–192 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Subclinical cognitive decline in middle-age is associated with reduced task-induced deactivation of the brain's default mode network

    Hansen, N. L., Lauritzen, Martin, Mortensen, Erik Lykke, Osler, Merete, Avlund, K., Fagerlund, Birgitte & Rostrup, E., Sep 2014, In: Human Brain Mapping. 35, 9, p. 4488-98 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracer

    Holm, L., Reitelseder, S., Dideriksen, K., Nielsen, R. H., Bülow, J. & Kjær, Michael, 23 Apr 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 11, p. E1330-39 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Aging impairs the recovery in mechanical muscle function following 4 days of disuse

    Hvid, L. G., Suetta, Charlotte, Nielsen, J., Jensen, M. M., Frandsen, U., Ørtenblad, N., Kjær, Michael & Aagaard, P., Apr 2014, In: Experimental Gerontology. 52, p. 1-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Eccentric exercise: acute and chronic effects on healthy and diseased tendons

    Kjær, Michael & Heinemeier, K. M., 1 Jun 2014, In: Journal of Applied Physiology. 116, 11, p. 1435-1438 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast

    Larsen, N. B., Sass, E., Suski, C., Mankouri, H. W. & Hickson, Ian David, 2014, In: Nature Communications. 5, p. 1-10 10 p., 3574.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes

    Larsen, N. B., Hickson, Ian David & Mankouri, H. W., 1 Oct 2014, In: Cell Cycle. 13, 19, p. 2994-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Myopati som årsag til akut opstået tetraparese på en intensivafdeling

    Lindqvist, J. K., Lauritzen, Martin, Laursen, H. & Benedek, K., 28 Jul 2014, In: Ugeskrift for Laeger. 176, 31, p. 2-3 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The origins and processing of ultra fine anaphase DNA bridges

    Liu, Ying, Nielsen, Christian Friberg, Yao, Q. & Hickson, Ian David, 30 Apr 2014, In: Current Opinion in Genetics & Development. 26C, p. 1-5 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Differential satellite cell density of type I and II fibres with lifelong endurance running in old men

    Mackey, Abigail, Karlsen, Anders, Couppé, Christian, Mikkelsen, U. R., Nielsen, R. H., Magnusson, Stig Peter & Kjær, Michael, Mar 2014, In: Acta Physiologica (Print). 210, 3, p. 612-27 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Desler, Claus, Zambach, S., Suravajhala, P. & Rasmussen, Lene Juel, 2014, In: International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Mitochondria in biology and medicine--2012

    Desler, Claus & Rasmussen, Lene Juel, May 2014, In: Mitochondrion. 16, p. 2-6 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  46. Published

    Lactate transport and receptor actions in cerebral malaria

    Mariga, S. T., Kolko, Miriam, Gjedde, Albert & Bergersen, L. H., 2014, In: Frontiers in Neuroscience. 8, p. 1-6 6 p., 2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Integrated Measurements of Electrical Activity, Oxygen Tension, Blood Flow, and Ca2+ -Signaling in Rodents In Vivo

    Mathiesen, C., Thomsen, K. & Lauritzen, Martin, 2014, Brain Energy Metabolism. Hirrlinger, J. & Waagepetersen, H. S. (eds.). p. 243-264 22 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  48. Published

    Integrated measurements of electrical activity, Oxygen tension, Blood flow, And Ca2+-Signaling in rodents in vivo

    Mathiesen, C., Thomsen, Kirsten Joan & Lauritzen, Martin, 1 Jan 2014, Brain Energy Metabolism. Vol. 90. p. 243-264 22 p. (Neuromethods).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Structure-specific endonucleases: guardians of fragile site stability

    Minocherhomji, S. & Hickson, Ian David, May 2014, In: Trends in Cell Biology. 24, 5, p. 321-327 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Functional adaptation of tendon and skeletal muscle to resistance training in three patients with genetically verified classic Ehlers Danlos Syndrome

    Møller, M. B., Kjær, Michael, Svensson, R. B., Andersen, J. L., Magnusson, Stig Peter & Nielsen, R. H., 2014, In: M.L.T.J. Muscles, Ligaments and Tendons Journal. 4, 3, p. 315-323 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

    Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Gray, L. T., Welsh, J. A., Schetter, A. J., Kumamoto, K., Wang, X. W., Hickson, Ian David, Maizels, N., Monnat, R. J. & Harris, C. C., 8 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9905-10 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure

    Nielsen, R. H., Clausen, N. M., Schjerling, Peter, Larsen, J. O., Martinussen, Torben, List, E. O., Kopchick, J. J., Kjær, Michael & Heinemeier, K. M., Feb 2014, In: Matrix Biology. 34, p. 96-104 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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