Damage and Repair

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  1. 2021
  2. Published

    Longevity medicine: upskilling the physicians of tomorrow

    Bischof, E., Scheibye-Knudsen, Morten, Siow, R. & Moskalev, A., 2021, In: The Lancet Healthy Longevity. 2, 4, p. e187-e188

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  3. Published

    Habitual side-specific loading leads to structural, mechanical, and compositional changes in the patellar tendon of young and senior lifelong male athletes

    Couppé, Christian, Svensson, R. B., Skovlund, S. V., Jensen, Jacob Kildevang, Eriksen, C. S., Malmgaard-Clausen, N. M., Nybing, J. D., Kjær, Michael & Magnusson, Stig Peter, 2021, In: Journal of Applied Physiology. 131, 4, p. 1187-1199

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Right-left asymmetry in corticospinal tract microstructure and dexterity are uncoupled in late adulthood

    Demnitz, N., Madsen, K. S., Johnsen, L. K., Kjær, Michael, Boraxbekk, CJ & Siebner, Hartwig Roman, 2021, In: NeuroImage. 240, 118405.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration

    Durhuus, J. A., Rozing, Maarten Pieter, Nielsen, M. K., Molbech, C. R., Keijzers, G., Scheibye-Knudsen, Morten, Rasmussen, Lene Juel, Westendorp, Rudi GJ & Sørensen, Torben Lykke, 2021, In: Scientific Reports. 11, 1, 8226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis

    Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, Indra John, Scheibye-Knudsen, Morten, De, S., Sen, P., Abdelmohsen, K. & Gorospe, M., 2021, In: Nucleic Acids Research. 49, 13, p. 7389-7405 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

    Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    RNA-sequencing and immunofluorescence of the myotendinous junction of mature horses and humans

    Jakobsen, J. R., Schjerling, Peter, Svensson, R. B., Buhl, Rikke, Carstensen, Helena, Koch, M., Rindom Krogsgaard, M. R., Kjær, Michael & Mackey, Abigail, 2021, In: American journal of physiology. Cell physiology. 321, p. C453–C470

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Adipocytes are present at human and murine myotendinous junctions

    Jakobsen, J. R., Jakobsen, N. R., Mackey, Abigail, Knudsen, A. B., Hannibal, Jens, Koch, M., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Translational Sports Medicine. 4, 2, p. 223-230

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

    Lauritzen, K. H., Olsen, M. B., Ahmed, M. S., Yang, K., Rinholm, J. E., Bergersen, L. H., Esbensen, Q. Y., Sverkeli, L. J., Ziegler, M., Attramadal, H., Halvorsen, B., Aukrust, P. & Yndestad, A., 2021, In: eLife. 10, 23 p., 59828.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Musculoskeletal sports medicine injuries in special operations forces soldiers

    Lendal, M. S. & Kjær, Michael, 2021, In: Translational Sports Medicine. 4, 6, p. 872-881 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    mHealth applications to support caregiver needs and engagement during stroke recovery: A content review

    Lobo, E. H., Frølich, Anne, Kensing, Finn, Rasmussen, Lene Juel, Livingston, P. M., Grundy, J. & Abdelrazek, M., 2021, In: Research in Nursing and Health. 44, 1, p. 213-225

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Magnetic Resonance T-2* Is Increased in Patients With Early-Stage Achilles and Patellar Tendinopathy

    Malmgaard-Clausen, N. M., Tran, P., Svensson, R. B., Hansen, Philip, Nybing, J. D., Magnusson, Stig Peter & Kjær, Michael, 2021, In: Journal of Magnetic Resonance Imaging. 54, 3, p. 832-839

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Collagens in primary frozen shoulder: expression of collagen mRNA isoforms in the different phases of the disease

    Marker, L., Schjerling, P., Mackey, Abigail, Hansen, T., Jakobsen, J., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Rheumatology. 60, 8, p. 3879-3887

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Tendon blood flow, angiogenesis, and tendinopathy pathogenesis

    Merkel, M. F. R., Hellsten, Ylva, Magnusson, Stig Peter & Kjær, Michael, 2021, In: Translational Sports Medicine. 4, 6, p. 756-771 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running

    Olesen, A. T., Alchow-Moller, L., Bendixen, R. D., Kjær, Michael, Svensson, R. B., Andersen, J. L. & Magnusson, Stig Peter, 2021, In: Experimental Gerontology. 143, 111150.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

    Peeters, M. J. W., Aehnlich, P., Pizzella, A., Mølgaard, K., Seremet, T., Met, Özcan, Rasmussen, Lene Juel, thor Straten, P. & Desler, Claus, 2021, In: Frontiers in Immunology. 12, 718863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Petr, Michael Angelo, Alfaras, I., Krawcyzk, M., Bair, W. N., Mitchell, S. J., Morrell, C. H., Studenski, S. A., Price, N. L., Fishbein, K. W., Spencer, R. G., Scheibye-Knudsen, Morten, Lakatta, E. G., Ferrucci, L., Aon, M. A., Bernier, M. & de Cabo, R., 2021, In: eLife. 10, 25 p., e62952.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Genetic insights into biological mechanisms governing human ovarian ageing

    Ruth, K. S., Day, F. R., Hussain, J., Martinez-Marchal, A., Aiken, C. E., Azad, A., Thompson, D. J., Knoblochova, L., Abe, H., Tarry-Adkins, J. L., Gonzalez, J. M., Fontanillas, P., Claringbould, A., Bakker, O. B., Sulem, P., Walters, R. G., Terao, C., Turon, S., Horikoshi, M., Lin, K. & 36 others, Onland-Moret, N. C., Sankar, A., Hertz, Emil Peter Thrane, Timshel, P. N., Shukla, V., Borup, R., Olsen, K. W., Aguilera, P., Ferrer-Roda, M., Huang, Y., Stankovic, S., Timmers, P. R. H. J., Ahearn, T. U., Alizadeh, B. Z., Naderi, E., Andrulis, I. L., Arnold, A. M., Aronson, K. J., Augustinsson, A., Bojesen, Stig Egil, Hoffding, M. K., Shrikhande, A., Pers, Tune H, Grøndahl, M. L., tcg964, tcg964, Lopez-Contreras, Andres, Daniel, J. A., Hoffmann, Eva, Biobank-based Integrative Omics St, B. I. O. S., eQTLGen Consortium, E. C., BioBank Japan Project, B. J. P., China Kadoorie Biobank Collaborati, C. K. B. C., kConFab Investigators, K. I., LifeLines Cohort Study, L. C. S., InterAct Consortium, I. C. & 23 Me Res Team, 2. M. R. T., 2021, In: Nature. 596, p. 393-397

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Resting in bed - how quickly does the muscle lose its nerve?

    Soendenbroe, C., Mackey, Abigail & Kjær, Michael, 2021, In: The Journal of Physiology. 599, 12, p. 2995-2996

    Research output: Contribution to journal › Editorial › Research

  21. Published

    Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes

    Subramanian, V., Rodemoyer, B., Shastri, V., Rasmussen, Lene Juel, Desler, Claus & Schmidt, K. H., 2021, In: Scientific Reports. 11, 2157.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Mechanical properties of human patellar tendon collagen fibrils. An exploratory study of aging and sex

    Svensson, R. B., Eriksen, C. S., Tran, P. H. T., Kjær, Michael & Magnusson, Stig Peter, 2021, In: Journal of the Mechanical Behavior of Biomedical Materials. 124, 104864.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Mutual stimulatory signaling between human myogenic cells and rat cerebellar neurons

    Tamáš, M., Pankratova, Stanislava, Schjerling, Peter, Soendenbroe, C., Yeung, C. C., Pennisi, C. P., Jakobsen, J. R., Krogsgaard, Michael R., Kjær, Michael & Mackey, Abigail, 2021, In: Physiological Reports. 9, 21, e15077.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

    The International Mismatch Repair Consortium, T. I. M. R. C., Jul 2021, In: The Lancet Oncology. 22, 7, p. 1014-1022 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2020
  26. Published

    Supraphysiological protection from replication stress does not extend mammalian lifespan

    Albers, E., Avram, Alexandra Ioana, Sbroggio, M., Fernandez-Capetillo, O. & Lopez-Contreras, Andres, 2020, In: Aging. 12, 7, p. 5612-5624 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In: Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    ATR expands embryonic stem cell fate potential in response to replication stress

    Atashpaz, S., Samadi Shams, S., Martin Gonzalez, Javier, Sebestyén, E., Arghavanifard, N., Gnocchi, A., Albers, E., Minardi, S., Faga, G., Soffientini, P., Allievi, E., Cancila, V., Bachi, A., Fernández-Capetillo, Ó., Tripodo, C., Ferrari, F., Lopez-Contreras, Andres & Costanzo, V., 2020, In: eLife. 9, e54756.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    MitophAging: Mitophagy in Aging and Disease

    Bakula, Daniela Janina & Scheibye-Knudsen, Morten, 2020, In: Frontiers in Cell and Developmental Biology. 8, 16 p., 239.

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon

    Bayer, M. L., Svensson, R. B., Schjerling, P., Williams, A. S., Wasserman, D. H. & Kjær, Michael, 2020, In: Cell and Tissue Research. 381, 1, p. 177-187

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The many lives of type IA topoisomerases

    Bizard, A. H. & Hickson, Ian David, 2020, In: Journal of Biological Chemistry. 295, 20, p. 7138-7153 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, Victoria Alexandra, Schönewolf-Greulich, B., Rasmussen, Lene Juel, Desler, Claus & Tümer, Asuman Zeynep, 2020, In: Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

    Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Bagge, Keerthana Stine Viswalingam, Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Tumour predisposition and cancer syndromes as models to study gene–environment interactions

    Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, Petrini, J. H., Schmidt, L. S. & Yang, H., 2020, In: Nature Reviews Cancer. 20, p. 533–549

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

    Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., Wong, H. S., Gibbs, E., Iyer, S. S., Basisty, N., Wu, Q., Kim, I. J., Silva, E., Vitangcol, K., Shin, K. O., Lee, Y. M. & 11 others, Riley, R., Ben-Sahra, I., Ott, M., Schilling, B., Scheibye-Knudsen, Morten, Ishihara, K., Quake, S. R., Newman, J., Brenner, C., Campisi, J. & Verdin, E., 2020, In: Nature Metabolism. 2, 11, p. 1265-1283 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Dahlqvist, M. K., Thomsen, Kirsten Joan, Postnov, D. D. & Lauritzen, Martin, 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40, 10, p. 2010-2025 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, In: Genetics in Medicine. 22, p. 847–856

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Ellegaard, M., Bieler, T., Beyer, N., Kjær, Michael & Jørgensen, Niklas Rye, 2020, In: Translational Sports Medicine. 3, 1, p. 16-25

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

    Garribba, L., Bjerregaard, Victoria Alexandra, Gonçalves Dinis, M. M., Özer, Ö., Wu, Wei, Sakellariou, D., Pena-Diaz, J., Hickson, Ian David & Liu, Ying, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 28, p. 16527-16536 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Maintenance of muscle strength following a one-year resistance training program in older adults

    Gylling, A. T., Bloch-Ibenfeldt, M., Eriksen, C. S., Ziegler, A. K., Wimmelmann, Cathrine Lawaetz, Bækgaard, M., Boraxbekk, CJ, Siebner, Hartwig Roman, Mortensen, Erik Lykke & Kjær, Michael, 2020, In: Experimental Gerontology. 139, 111049.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Gylling, A. T., Eriksen, C. S., Garde, Ellen, Wimmelmann, Cathrine Lawaetz, Reislev, N. L., Bieler, T., Ziegler, A. K., Andersen, K. W., Bauer, C., Dideriksen, K., Bækgaard, M., Mertz, K. H., Bayer, M. L., Bloch-Ibenfeldt, M., Boraxbekk, CJ, Siebner, Hartwig Roman, Mortensen, Erik Lykke & Kjær, Michael, 2020, In: Experimental Gerontology. 136, 110939.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

    Harpelunde Poulsen, K., Nielsen, J. E., Grønkær Toft, B., Joensen, Ulla Nordström, Rasmussen, Lene Juel, Blomberg Jensen, M., Mitchell, R. T., Juul, Anders, Rajpert-De Meyts, E. & Jørgensen, Anders, 2020, In: BMC Cancer. 20, 1, 14 p., 349.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Early Growth Response Genes Increases Rapidly After Mechanical Overloading and Unloading in Tendon Constructs

    Herchenhan, A., Dietrich-Zagonel, F., Schjerling, P., Kjær, Michael & Eliasson, P., 2020, In: Journal of Orthopaedic Research. 38, 1, p. 173-181

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Histology and Function of the Rectus Abdominis Muscle in Patients With Incisional Hernia

    Jensen, K. K., Oma, E., Kjær, Michael, Jørgensen, Lars Nannestad & Andersen, J. L., 2020, In: Journal of Surgical Research. 253, p. 245-251 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Macrophage Subpopulations and the Acute Inflammatory Response of Elderly Human Skeletal Muscle to Physiological Resistance Exercise

    Jensen, S. M., Bechshøft, C. J. L., Heisterberg, M. F., Schjerling, P., Andersen, J. L., Kjær, Michael & Mackey, Abigail, 2020, In: Frontiers in Physiology. 11, 15 p., 811.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

    Karlsen, Anders, Soendenbroe, C., Malmgaard‐clausen, N. M., Wagener, F., Moeller, C. E., Senhaji, Z., Damberg, K., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 2020, In: The FASEB Journal. 34, 5, p. 6418-6436

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    What is the impact of acute inflammation on muscle performance in geriatric patients?

    Karlsen, Anders, Mackey, Abigail, Suetta, Charlotte & Kjær, Michael, 1 Jun 2020, In: Experimental Gerontology. 138, 8 p., 111008.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Adrenergic Regulation of Energy Metabolism

    Kjær, Michael & Lange, Kai, 2020, Endocrinology of Physical Activity and Sport. Humana Press, p. 153-159 (Contemporary Endocrinology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  51. Published

    TIP60 in aging and neurodegeneration

    Li, Zhiquan & Rasmussen, Lene Juel, 2020, In: Ageing Research Reviews. 64, 101195.

    Research output: Contribution to journal › Review › Research › peer-review

  52. Published

    Mitophagy and Neuroprotection

    Lou, G., Palikaras, K., Lautrup, S., Scheibye-Knudsen, Morten, Tavernarakis, N. & Fang, E. F., 2020, In: Trends in Molecular Medicine. 26, 1, p. 8-20

    Research output: Contribution to journal › Review › Research › peer-review

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