Leucocyte Telomere Length and Risk of Cardiovascular Disease in a Cohort of 1,397 Danish Men and Women
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Leucocyte Telomere Length and Risk of Cardiovascular Disease in a Cohort of 1,397 Danish Men and Women. / Ellehoj, Hanne; Bendix, Laila; Osler, Merete.
In: Cardiology, Vol. 133, No. 3, 02.2016, p. 173-177.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Leucocyte Telomere Length and Risk of Cardiovascular Disease in a Cohort of 1,397 Danish Men and Women
AU - Ellehoj, Hanne
AU - Bendix, Laila
AU - Osler, Merete
N1 - © 2015 S. Karger AG, Basel.
PY - 2016/2
Y1 - 2016/2
N2 - OBJECTIVES: Short leucocyte telomere length (LTL) might be a risk factor for cardiovascular diseases (CVD). The present study examines the relation between LTL and incident fatal or non-fatal CVD, ischaemic heart disease (IHD) and stroke in a Danish cohort followed for 29 years.METHODS: In total, 1,397 men and women who participated in health examinations with blood sampling in 1981-1984 were followed for CVD outcomes until the end of 2012 by linkage to national registers. Cox proportional hazard regression models were used to analyse the relation between LTL and CVD adjusting for potential confounding CVD risk factors.RESULTS: During the follow-up, 603 participants experienced an incident fatal or non-fatal CVD. The survival analysis showed that baseline LTL was not associated with CVD outcomes. In the subanalysis with IHD as outcome, those with middle and short LTL had an increased hazard rate ratio of 1.97 (95% CI 1.31-2.93) and 1.55 (95% CI 1.02-2.35), respectively, which was attenuated when confounding factors were adjusted for. For stroke, the pattern of associations was similar but less precisely estimated.CONCLUSIONS: In this study short, LTL was not associated with an increased risk of CVD, but modestly associated with an increased risk of IHD.
AB - OBJECTIVES: Short leucocyte telomere length (LTL) might be a risk factor for cardiovascular diseases (CVD). The present study examines the relation between LTL and incident fatal or non-fatal CVD, ischaemic heart disease (IHD) and stroke in a Danish cohort followed for 29 years.METHODS: In total, 1,397 men and women who participated in health examinations with blood sampling in 1981-1984 were followed for CVD outcomes until the end of 2012 by linkage to national registers. Cox proportional hazard regression models were used to analyse the relation between LTL and CVD adjusting for potential confounding CVD risk factors.RESULTS: During the follow-up, 603 participants experienced an incident fatal or non-fatal CVD. The survival analysis showed that baseline LTL was not associated with CVD outcomes. In the subanalysis with IHD as outcome, those with middle and short LTL had an increased hazard rate ratio of 1.97 (95% CI 1.31-2.93) and 1.55 (95% CI 1.02-2.35), respectively, which was attenuated when confounding factors were adjusted for. For stroke, the pattern of associations was similar but less precisely estimated.CONCLUSIONS: In this study short, LTL was not associated with an increased risk of CVD, but modestly associated with an increased risk of IHD.
KW - Adult
KW - Aged
KW - Cardiovascular Diseases
KW - Cohort Studies
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Leukocytes
KW - Male
KW - Medical Record Linkage
KW - Middle Aged
KW - Myocardial Ischemia
KW - Proportional Hazards Models
KW - Registries
KW - Risk Factors
KW - Stroke
KW - Surveys and Questionnaires
KW - Telomere Homeostasis
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1159/000441819
DO - 10.1159/000441819
M3 - Journal article
C2 - 26666879
VL - 133
SP - 173
EP - 177
JO - Cardiologia
JF - Cardiologia
SN - 0008-6312
IS - 3
ER -
ID: 167754874