Niklas Rye Jørgensen

Niklas Rye Jørgensen

Clinical Professor

Member of:

  • Clinical Biochemistry


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  1. Published

    1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

    Sønderby, I. E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G. B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N. J., Bernard, M., Blackburn, N. B., Blangero, J., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Bülow, R., Bøen, R., Cahn, W. & 31 others, Calhoun, V. D., Caspers, S., Ching, C. R. K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J. E., Dale, A. M., Dalvie, S., Dazzan, P., de Geus, E. J. C., de Zubicaray, G. I., de Zwarte, S. M. C., Desrivieres, S., Doherty, J. L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S. E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Ge, T., Glahn, D. C., Jørgensen, Niklas Rye & ENIGMA-CNV working group, E. W. G., 2021, In: Translational Psychiatry. 11, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen (ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM)

    Cavalier, E., Eastell, R., Jørgensen, Niklas Rye, Makris, K., Tournis, S., Vasikaran, S., Kanis, J. A., Cooper, C., Pottel, H., Morris, H. A. & on behalf of the IFCC-IOF Committee for Bone Metabolism (C-BM), O. B. O. T. I. C. F. B. M. (., 2021, In: Calcified Tissue International. 108, p. 785–797

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A Systematic Review of the Circadian Rhythm of Bone Markers in Blood

    Diemar, S. S., Dahl, S. S., West, A. S., Simonsen, S. A., Iversen, Helle Klingenberg & Jørgensen, Niklas Rye, 2023, In: Calcified Tissue International. 112, 2, p. 126–147 22 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    A feasibility study of training in a local community aimed upon health promotion with special emphasis on musculoskeletal health effects

    Prawiradilaga, R. S., Bendtsen, M., Esrup, S., Jørgensen, Niklas Rye, Yulianto, F. A. & Helge, Eva Wulff, 2023, In: F1000Research. 11, 13 p., 51.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A review of sleep research in patients with spinal cord injury

    Hultén, V. D. T., Biering-Sørensen, Fin, Jørgensen, Niklas Rye & Jennum, Poul, 2020, In: The Journal of Spinal Cord Medicine. 43, 6, p. 775-796

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    Absence of P2Y2 Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss

    Agrawal, A., Ellegaard, M., Haanes, Kristian Agmund, Wang, N., Gartland, A., Ding, M., Praetorius, H. & Jørgensen, Niklas Rye, 2022, In: Frontiers in Endocrinology. 13, 17 p., 850525.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Accelerated tumor progression in mice lacking the ATP receptor P2X7

    Adinolfi, E., Capece, M., Franceschini, A., Falzoni, S., Giuliani, A. L., Rotondo, A., Sarti, A. C., Bonora, M., Syberg, S., Corigliano, D., Pinton, P., Jørgensen, Niklas Rye, Abelli, L., Emionite, L., Raffaghello, L., Pistoia, V. & Di Virgilio, F., 15 Feb 2015, In: Cancer Research. 75, 4, p. 635-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Adipose derived mesenchymal stem cells – Their osteogenicity and osteoblast in vitro mineralization on titanium granule carriers

    Dahl, M., Syberg, S., Jørgensen, Niklas Rye & Pinholt, E. M., 13 Nov 2013, In: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 41, 2013, p. 213 -220 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

    Jakobsen, L. M. A., He, W., Ditzel, N., Danielsen, M., Dalsgaard, T. K., Jørgensen, Niklas Rye, Bollen, Peter & Bertram, H. C., 2022, In: Food and Function. 13, 8, p. 4691-4698

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Adrenal suppression in patients with chronic obstructive pulmonary disease treated with glucocorticoids: Role of specific glucocorticoid receptor polymorphisms

    Sivapalan, P., Borresen, S. W., Ekloef, J., Klose, M., Holm, F. S., Feldt-Rasmussen, Ulla, Rossing, M., Jørgensen, Niklas Rye, Marvig, R. L., Saeed, M. I., Wilcke, T., Seersholm, N., Mathioudakis, A. G., Vestbo, J. & Jensen , Jens-Ulrik Stæhr , 4 Feb 2022, In: PLoS ONE. 17, 2, 14 p., 0262898.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Adults with pathogenic MC4R mutations have increased final height and thereby increased bone mass

    Iepsen, E. W., Zhang, J., Hollensted, M., Madsbad, Sten, Hansen, Torben, Holst, Jens Juul, Jørgensen, Niklas Rye, Holm, Jens-Christian & Torekov, Signe Sørensen, 2020, In: Journal of Bone and Mineral Metabolism. 38, 1, p. 117-125 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis

    Lorentzon, M., Branco, J., Brandi, M. L., Bruyère, O., Chapurlat, R., Cooper, C., Cortet, B., Diez-Perez, A., Ferrari, S., Gasparik, A., Herrmann, M., Jorgensen, N. R., Kanis, J., Kaufman, J-M., Laslop, A., Locquet, M., Matijevic, R., McCloskey, E., Minisola, S., Pikner, R. & 5 others, Reginster, J., Rizzoli, R., Szulc, P., Vlaskovska, M. & Cavalier, E., Oct 2019, In: Advances in Therapy. 36, 10, p. 2811-2824 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis

    Skals, M., Jørgensen, Niklas Rye, Leipziger, J. & Praetorius, H. A., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 10, p. 4030-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Amylin analog pramlintide induces migraine-like attacks in patients

    Ghanizada, H., Al-Karagholi, M. A., Walker, C. S., Arngrim, N., Rees, T., Petersen, J., Siow, A., Mørch-Rasmussen, M., Tan, S., O'Carroll, S. J., Harris, P., Skovgaard, Lene Theil, Jørgensen, Niklas Rye, Brimble, M., Waite, J. S., Rea, B. J., Sowers, L. P., Russo, A. F., Hay, D. L. & dlt446, dlt446, 2021, In: Annals of Neurology. 89, 6, p. 1157-1171 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today?

    Bjerg, L. N., Halgreen, J. R., Hansen, S. H., Morris, H. A. & Jørgensen, Niklas Rye, Jun 2019, In: Journal of Steroid Biochemistry and Molecular Biology. 190, p. 224-233

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    An explorative literature review of the multifactorial causes of osteoporosis in epilepsy

    Diemar, S. S., Sejling, A. S., Eiken, P., Andersen, N. B. & Jørgensen, Niklas Rye, Nov 2019, In: Epilepsy and Behavior. 100, Part A, 10 p., 106511.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

    Bhattoa, H. P., Cavalier, E., Eastell, R., Heijboer, A. C., Jørgensen, Niklas Rye, Makris, K., Ulmer, C. Z., Kanis, J. A., Cooper, C., Silverman, S. L. & Vasikaran, S. D., 2021, In: Clinica Chimica Acta. 515, p. 16-20 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population

    Priskorn, L., Bang, A. K., Nordkap, L., Krause, M., Mendiola, J., Jensen, T. K., Juul, Anders, Skakkebæk, Niels Erik, Swan, S. H. & Jørgensen, Niklas Rye, 1 Jan 2019, In: Human reproduction (Oxford, England). 34, 1, p. 12-24 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Application of high resolution synchrotron micro-CT radiation in dental implant osseointegration

    Neldam, C. A., Lauridsen, T., Rack, A., Lefolii, T. T., Jørgensen, Niklas Rye, Feidenhans'l, Robert Krarup & Pinholt, E. M., 1 Jun 2015, In: Journal of Cranio-Maxillofacial Surgery. 43, 5, p. 682-687 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Assessment of acute bone loading in humans using [18F]NaF PET/MRI

    Haddock, B., Fan, A. P., Uhlrich, S. D., Jørgensen, Niklas Rye, Suetta, Charlotte, Gold, G. E. & Kogan, F., Nov 2019, In: European Journal of Nuclear Medicine and Molecular Imaging. 46, 12, p. 2452-2463 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

    Wesselius, A., Bours, M. J. L., Henriksen, Z., Syberg, S., Petersen, S., Schwarz, Peter, Jørgensen, Niklas Rye, van Helden, S. & Dagnelie, P. C., 2013, In: Osteoporosis International. 24, 4, p. 1235-1246 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Association of P2Y(2) receptor SNPs with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

    Wesselius, A., Bours, M. J. L., Henriksen, Z., Syberg, S., Petersen, S., Schwarz, Peter, Jørgensen, Niklas Rye, van Helden, S. & Dagnelie, P. C., 2013, In: Purinergic Signalling. 9, 1, p. 41-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Associations between inflammatory markers, body composition, and physical function: the Copenhagen Sarcopenia Study

    Kamper, R. S., Alcazar, J., Andersen, L. L., Haddock, B., Jørgensen, Niklas Rye, Hovind, P. & Suetta, Charlotte, 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12, 6, p. 1641-1652

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study

    Faurholt-Jepsen, M., Frøkjær, Vibe Gedsø, Nasser, A., Jørgensen, Niklas Rye, Kessing, Lars Vedel & Vinberg, Maj, Dec 2021, In: International Journal of Bipolar Disorders. 9, 1, 10 p., 8.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Automated Interlaboratory Comparison of Therapeutic Drug Monitoring Data and Its Use for Evaluation of Published Therapeutic Reference Ranges

    Larsen, J. B., Hoffmann-Lücke, E., Aaslo, P. H., Jørgensen, Niklas Rye & Greibe, E., 2023, In: Pharmaceutics. 15, 2, 19 p., 673.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Baseline bone turnover marker levels can predict change in bone mineral density during antiresorptive treatment in osteoporotic patients: the Copenhagen bone turnover marker study

    Bønløkke, S. E., Rand, M. S., Haddock, B., Arup, S., Smith, C. D., Jensen, Jens-Erik Beck, Schwarz, Peter, Hovind, P., Oturai, P. S., Jensen, Lars Thorbjørn, Møller, Søren, Eiken, P., Rubin, K. H., Hitz, Mette Friberg, Abrahamsen, B. & Jørgensen, Niklas Rye, 2022, In: Osteoporosis International. 33, p. 2155–2164

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Biochemical and clinical manifestations in adults with hypophosphatasia: a national cross-sectional study

    Hepp, N., Frederiksen, A. L., Duno, M., Jørgensen, Niklas Rye & Jensen, Jens-Erik Beck, 2022, In: Osteoporosis International. 33, p. 2595–2605 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark

    Hepp, N., Frederiksen, A. L., Duno, M., Præst Holm, J., Jørgensen, Niklas Rye & Jensen, Jens-Erik Beck, 2021, In: Bone Reports. 15, 101101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT

    Folkestad, L., Groth, K. A., Shanbhogue, V., Hove, H., Kyhl, K., Østergaard, J. R., Jørgensen, Niklas Rye, Andersen, N. H. & Gravholt, C. H., 2020, In: Journal of Bone and Mineral Research. 35, 12, p. 2335-2344

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients With Type 1 Diabetes Mellitus

    Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, Niklas Rye, Hermann, A. P., Henriksen, J. E. & Brixen, K., Dec 2015, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30, 12, p. 2188-99 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Klinefelter Syndrome

    Shanbhogue, V. V., Hansen, S., Jørgensen, Niklas Rye, Brixen, K. & Gravholt, C. H., Nov 2014, In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 11, p. 2474–2482 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Bone Health in Patients with Type 2 Diabetes Treated by Roux-En-Y Gastric Bypass and the Role of Diabetes Remission

    Madsen, L. R., Espersen, R., Ornstrup, M. J., Jørgensen, Niklas Rye, Langdahl, B. L. & Richelsen, B., Jun 2019, In: Obesity Surgery. 29, 6, p. 1823-1831 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Bone Involvement in Patients with Spondyloarthropathies

    Lems, W., Miceli-Richard, C., Haschka, J., Giusti, A., Chistensen, G. L., Kocijan, R., Rosine, N., Jørgensen, Niklas Rye, Bianchi, G. & Roux, C., 2022, In: Calcified Tissue International. 110, 4, p. 393-420 28 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Bone mass development in childhood and its association with physical activity and vitamin D levels. The CHAMPS-Study DK

    Rønne, M. S., Heidemann, M., Lylloff, L., Schou, A. J., Tarp, J., Laursen, J. O., Jørgensen, Niklas Rye, Husby, S., Wedderkopp, N. & Mølgaard, Christian, 2019, In: Calcified Tissue International. 104, 1, p. 1-13 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Bone mass development is sensitive to insulin resistance in adolescent boys

    Rønne, M. S., Heidemann, M., Lylloff, L., Schou, A. J., Tarp, J., Bugge, A., Laursen, J. O., Jørgensen, Niklas Rye, Husby, S., Wedderkopp, N. & Mølgaard, Christian, 2019, In: Bone. 122, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?

    Ellegaard, M., Hegner, T., Ding, M., Ulmann, L. & Jørgensen, Niklas Rye, 2021, In: Purinergic Signalling. 17, p. 241–246

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Bone resorption is unchanged by liraglutide in type 2 diabetes patients: A randomised controlled trial

    Hygum, K., Harsløf, T., Jørgensen, Niklas Rye, Rungby, Jørgen, Pedersen, S. B. & Langdahl, B. L., 2020, In: Bone. 132, 9 p., 115197.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study

    Shanbhogue, V. V., Støving, R. K., Frederiksen, K. H., Hanson, S., Brixen, K., Gram, J., Jørgensen, Niklas Rye & Hansen, S., 2017, In: European Journal of Endocrinology. 176, 6, p. 685-693

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: A substudy of the randomized controlled CORTICO-COP trial

    Sivapalan, P., Jørgensen, Niklas Rye, Mathioudakis, A. G., Eklöf, J., Lapperre, T., Ulrik, Charlotte Suppli, Andreassen, H. F., Armbruster, K., Sivapalan, P., Janner, J., Godtfredsen, Nina, Weinreich, U. M., Nielsen, T. L., Seersholm, N., Wilcke, T., Schuetz, P., Klausen, T. W., Marså, K., Vestbo, J. & Jensen , Jens-Ulrik Stæhr , 2020, In: Respiratory research. 21, 263.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor

    Ellegaard, M., Agca, C., Petersen, S., Agrawal, A., Kruse, L. S., Wang, N., Gartland, A., Jensen, J. B., Jørgensen, Niklas Rye & Agca, Y., 2017, In: Purinergic Signalling. 13, 4, p. 545-557

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Bone turnover markers are differentially affected by pre-analytical handling

    Christensen, G. L., Halgreen, J. R., Milenkovski, M., Köse, A., Quardon, N. & Jørgensen, Niklas Rye, May 2019, In: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 30, 5, p. 1137-1141 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  42. Published

    Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

    Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jensen, Andreas Kryger, Jørgensen, Niklas Rye, Olsen, B. S., Svensson, Jannet, Pociot, Flemming & Johannesen, Jesper, 2020, In: Pediatric Diabetes. 21, 2, p. 366-376 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Bone-microarchitecture and bone-strength in a sample of adults with hypophosphatasia and a matched reference population assessed by HR-pQCT and impact microindentation

    Hepp, N., Folkestad, L., Møllebæk, S., Frederiksen, A. L., Duno, M., Jørgensen, Niklas Rye, Hermann, A. P. & Jensen, Jens-Erik Beck, 2022, In: Bone. 160, 116420.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Calcitonin-gene related peptide and disease activity in cluster headache

    Snoer, A., Vollesen, A. L. H., Beske, R. P., Guo, S., Hoffmann, J., Fahrenkrug, J., Jørgensen, Niklas Rye, Martinussen, Torben, Jensen, Rigmor Højland & dlt446, dlt446, 2019, In: Cephalalgia. 39, 5, p. 575-584

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Carriers in mesenchymal stem cell osteoblast mineralization-State-of-the-art

    Dahl, M., Jørgensen, Niklas Rye, Hørberg, M. & Pinholt, E. M., Jan 2014, In: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 42, 1, p. 41-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Changes in RANKL and TRAcP 5b after discontinuation of denosumab suggest RANKL mediated formation of osteoclasts results in the increased bone resorption

    Solling, A. S., Harslof, T., Jørgensen, Niklas Rye & Langdahl, B., 2023, In: Osteoporosis International. 34, p. 599–605 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Characterization of pectin nanocoatings at polystyrene and titanium surfaces

    Gurzawska, K. A., Dirscherl, K., Yihua, Y., Chrestensen, I. B., Jørgensen, Bodil, Svava, R., Nielsen, M. W., Jørgensen, Niklas Rye & Gotfredsen, Klaus, 2013, In: Journal of Surface Engineered Materials and Advanced Technology. 3, p. 20-28 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Chronic hyponatremia - Why care? A case report

    Diemar, S. S., Sejling, A., Jørgensen, Niklas Rye & Andersen, N. B., 2018, In: Seizure. 59, p. 123-125

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

    Hansen, Ditte, Bressendorff, I., Nordholm, A., Jacobsen, A. A., Klausen, T. W. & Jørgensen, Niklas Rye, 2022, In: Bone Reports. 16, 7 p., 101593.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Clinical usefulness of bone turnover marker concentrations in osteoporosis

    IFCC-IOF Working Group for Standardisation of Bone Marker Assays (WG-BMA), I. W. G. F. S. O. B. M. A. (., 2017, In: Clinica Chimica Acta. 467, p. 34-41

    Research output: Contribution to journal › Review › Research › peer-review

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