Niklas Rye Jørgensen
Clinical Professor
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Epidemiology of forearm fractures in adults in Denmark: national age- and gender-specific incidence rates, ratio of forearm to hip fractures, and extent of surgical fracture repair in inpatients and outpatients
Abrahamsen, B., Jørgensen, Niklas Rye & Schwarz, Peter, Jan 2015, In: Osteoporosis international with other metabolic bone diseases. 26, 1, p. 67-76 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accelerated tumor progression in mice lacking the ATP receptor P2X7
Adinolfi, E., Capece, M., Franceschini, A., Falzoni, S., Giuliani, A. L., Rotondo, A., Sarti, A. C., Bonora, M., Syberg, S., Corigliano, D., Pinton, P., Jørgensen, Niklas Rye, Abelli, L., Emionite, L., Raffaghello, L., Pistoia, V. & Di Virgilio, F., 15 Feb 2015, In: Cancer Research. 75, 4, p. 635-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I
Aegidius, H. M., Kruse, L., Christensen, G. L., Lorentzen, M. P., Jørgensen, Niklas Rye, Moresco, M., Pizza, F., Plazzi, G., Jennum, Poul & Kornum, Birgitte Rahbek, 2021, In: Brain Communications. 3, 2, 13 p., 050.Research output: Contribution to journal › Journal article › Research › peer-review
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Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts
Agrawal, A., Kruse, L. S., Vangsted, Annette Juul, Gartland, A. & Jørgensen, Niklas Rye, 2020, In: Cells. 9, 11Research output: Contribution to journal › Journal article › Research › peer-review
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P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts
Agrawal, A., Henriksen, Z., Syberg, S., Petersen, S., Aslan, D., Solgaard, M., Nissen, N., Larsen, T. K., Schwarz, Peter, Steinberg, T. H. & Jørgensen, Niklas Rye, Feb 2017, In: Bone. 95, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular purines and bone homeostasis
Agrawal, A. & Jørgensen, Niklas Rye, 2021, In: Biochemical Pharmacology. 187, 8 p., 114425.Research output: Contribution to journal › Review › Research › peer-review
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Absence of P2Y2 Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss
Agrawal, A., Ellegaard, M., Haanes, Kristian Agmund, Wang, N., Gartland, A., Ding, M., Praetorius, H. & Jørgensen, Niklas Rye, 2022, In: Frontiers in Endocrinology. 13, 17 p., 850525.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired bone health as a co-morbidity of epilepsy
Andersen, N. B. & Jørgensen, Niklas Rye, 2022, In: Best Practice and Research: Clinical Rheumatology. 36, 3, 7 p., 101755.Research output: Contribution to journal › Review › Research › peer-review
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Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide
Andrikopoulos, P., Aron-Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S. K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira-Silva, S., Falony, G., Salem, J. E., Andreelli, F., Belda, E., Kieswich, J., Chechi, K., Puig-Castellvi, F., Chevalier, M., Le Chatelier, E., Olanipekun, M. T. & 83 others, , 2023, In: Nature Communications. 14, 18 p., 5843.Research output: Contribution to journal › Journal article › Research › peer-review
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Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury
Ashina, H., Al-Khazali, H. M., Iljazi, A., Ashina, Sait, Jørgensen, Niklas Rye, Amin, Faisal Mohammad, dlt446, dlt446 & Schytz, Henrik Winther, 2020, In: Cephalalgia. 40, 12, p. 1276-1282 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic bone disease in patients with epilepsy and the use of antiepileptic drugs – Insight from a Danish cross-sectional study
Baddoo, D. R., Mills, A. A., Kullab, R. B., Al-Mashat, H., Andersen, N. B., Jørgensen, Niklas Rye & Diemar, S. S., Mar 2021, In: Seizure. 86, p. 29-34 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mono- and co-activation of the GIP and GLP-1 receptors inhibits bone resorption
Bergmann, N. C., Lund, A., Heimburger, S. M., Gasbjerg, Lærke Smidt, Jørgensen, Niklas Rye, Jessen, L., Hartmann, Bolette, Holst, Jens Juul, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetologia. 61, S.1, p. S348-S348 717.Research output: Contribution to journal › Conference abstract in journal › Research
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Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
Bhattoa, H. P., Cavalier, E., Eastell, R., Heijboer, A. C., Jørgensen, Niklas Rye, Makris, K., Ulmer, C. Z., Kanis, J. A., Cooper, C., Silverman, S. L. & Vasikaran, S. D., 2021, In: Clinica Chimica Acta. 515, p. 16-20 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today?
Bjerg, L. N., Halgreen, J. R., Hansen, S. H., Morris, H. A. & Jørgensen, Niklas Rye, Jun 2019, In: Journal of Steroid Biochemistry and Molecular Biology. 190, p. 224-233Research output: Contribution to journal › Journal article › Research › peer-review
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Insulin resistance is associated with multiple chemical sensitivity in a danish population-based study—DanFunD
Bjerregaard, A. A., Petersen, M. W., Gormsen, L. K., Skovbjerg, S., Jørgensen, Niklas Rye, Linneberg, Allan René, Cedeño-Laurent, J. G., Jørgensen, T. & Dantoft, T. M., 2021, In: International Journal of Environmental Research and Public Health. 18, 23, 12654.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
Bjørnsbo, K. S., Brøns, C., Aadahl, M., Kampmann, F. B., Friis Bryde Nielsen, C., Lundbergh, B., Christensen, R. W., Kårhus, L. L., Madsen, A. L., Hansen, C. S., Nørgaard, K., Jørgensen, N. R., Suetta, C., Kjaer, M., Grarup, N., Kanters, J., Larsen, M., Køber, L., Kofoed, K. F., Loos, R. & 3 others, , 2024, In: BMJ Open. 14, 1, 10 p., e078501.Research output: Contribution to journal › Journal article › Research › peer-review
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Mineralocorticoid Receptor Antagonist Improves Cardiac Structure in Type 2 Diabetes: Data From the MIRAD Trial
Brandt-Jacobsen, N. H., Lav Madsen, P., Johansen, M. L., Rasmussen, J. J., Forman, Julie Lyng, Holm, M. R., Jørgensen, Niklas Rye, Faber, Jens, Rossignol, P., Schou, Morten & Kistorp, Caroline Michaela Nervil, 2021, In: JACC: Heart Failure. 9, 8, p. 550-558 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study
Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, Niklas Rye, drb459, drb459, Hansen, Torben, Hansen, T. H., Pedersen, Oluf Borbye & Nielsen, T., 2019, In: Diabetologia. 62, 6, p. 1024-1035Research output: Contribution to journal › Journal article › Research › peer-review
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Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study
Buch-Larsen, K., Jørgensen, Niklas Rye, Jensen, Lars Thorbjørn, Andersson, M. & Schwarz, Peter, 2021, In: Scandinavian Journal of Clinical and Laboratory Investigation. 81, 6, p. 425-431Research output: Contribution to journal › Journal article › Research › peer-review
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Baseline bone turnover marker levels can predict change in bone mineral density during antiresorptive treatment in osteoporotic patients: the Copenhagen bone turnover marker study
Bønløkke, S. E., Rand, M. S., Haddock, B., Arup, S., Smith, C. D., Jensen, Jens-Erik Beck, Schwarz, Peter, Hovind, P., Oturai, P. S., Jensen, Lars Thorbjørn, Møller, Søren, Eiken, P., Rubin, K. H., Hitz, Mette Friberg, Abrahamsen, B. & Jørgensen, Niklas Rye, 2022, In: Osteoporosis International. 33, p. 2155–2164Research output: Contribution to journal › Journal article › Research › peer-review
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European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates of β-isomerized C-terminal telopeptide of type I collagen (β-CTX), N-terminal propeptide of type I collagen (PINP), osteocalcin, intact fibroblast growth factor 23 and uncarboxylated-unphosphorylated matrix-Gla protein-a cooperation between the EFLM Working Group on Biological Variation and the International Osteoporosis Foundation-International Federation of Clinical Chemistry Committee on Bone Metabolism
Cavalier, E., Lukas, P., Bottani, M., Aarsand, A. K., Ceriotti, F., Coşkun, A., Díaz-Garzón, J., Fernàndez-Calle, P., Guerra, E., Locatelli, M., Sandberg, S., Carobene, A., European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation and IOF-IFCC Committee on Bone Metabolism, E. F. O. C. C. A. L. M. W. G. O. B. V. A. I. C. O. B. M., Åkesson, K., Bhattoa, H. P., Bruyère, O., Jørgensen, Niklas Rye, Makris, K., Ulmer, C. Z. & Vasikaran, S. D., 2020, In: Osteoporosis International. 31, 8, p. 1461-1470Research output: Contribution to journal › Journal article › Research › peer-review
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A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen (ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM)
Cavalier, E., Eastell, R., Jørgensen, Niklas Rye, Makris, K., Tournis, S., Vasikaran, S., Kanis, J. A., Cooper, C., Pottel, H., Morris, H. A. & on behalf of the IFCC-IOF Committee for Bone Metabolism (C-BM), O. B. O. T. I. C. F. B. M. (., 2021, In: Calcified Tissue International. 108, p. 785–797Research output: Contribution to journal › Journal article › Research › peer-review
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Bone turnover markers are differentially affected by pre-analytical handling
Christensen, G. L., Halgreen, J. R., Milenkovski, M., Köse, A., Quardon, N. & Jørgensen, Niklas Rye, May 2019, In: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 30, 5, p. 1137-1141 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia
Christensen, Mikkel Bring, Lund, A., Calanna, S., Jørgensen, Niklas Rye, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jan 2018, In: The Journal of clinical endocrinology and metabolism. 103, 1, p. 288-294Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Reduces Bone Resorption in Patients With Type 2 Diabetes
Christensen, Mikkel Bring, Lund, A. B., Jørgensen, Niklas Rye, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Journal of the endocrine society. 4, 9, 9 p., 097.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes
Crusell, Mie Korslund Wiinblad, Hansen, T. H., Nielsen, T., Allin, K. H., Rühlemann, M. C., Damm, Peter, Vestergaard, H., Rørbye, Christina, Jørgensen, Niklas Rye, Christiansen, O. B., Heinsen, F. A., Franke, A., Hansen, Torben, Lauenborg, J. & Pedersen, Oluf Borbye, 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 14 p., 536282.Research output: Contribution to journal › Journal article › Research › peer-review
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Carriers in mesenchymal stem cell osteoblast mineralization-State-of-the-art
Dahl, M., Jørgensen, Niklas Rye, Hørberg, M. & Pinholt, E. M., Jan 2014, In: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 42, 1, p. 41-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adipose derived mesenchymal stem cells – Their osteogenicity and osteoblast in vitro mineralization on titanium granule carriers
Dahl, M., Syberg, S., Jørgensen, Niklas Rye & Pinholt, E. M., 13 Nov 2013, In: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 41, 2013, p. 213 -220 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Systematic Review of the Circadian Rhythm of Bone Markers in Blood
Diemar, S. S., Dahl, S. S., West, A. S., Simonsen, S. A., Iversen, Helle Klingenberg & Jørgensen, Niklas Rye, 2023, In: Calcified Tissue International. 112, 2, p. 126–147 22 p.Research output: Contribution to journal › Review › Research › peer-review
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Chronic hyponatremia - Why care? A case report
Diemar, S. S., Sejling, A., Jørgensen, Niklas Rye & Andersen, N. B., 2018, In: Seizure. 59, p. 123-125Research output: Contribution to journal › Journal article › Research › peer-review
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Reference intervals in Danish children and adolescents for bone turnover markers carboxy-terminal cross-linked telopeptide of type I collagen (β-CTX), pro-collagen type I N-terminal propeptide (PINP), osteocalcin (OC) and bone-specific alkaline phosphatase (bone ALP)
Diemar, S. S., Lylloff, L., Rønne, M. S., Møllehave, Line Tang, Heidemann, M., Thuesen, B. H., Johannesen, Jesper, Schou, A. J., Husby, S., Wedderkopp, N., Mølgaard, Christian & Jørgensen, Niklas Rye, 2021, In: Bone. 146, 9 p., 115879.Research output: Contribution to journal › Journal article › Research › peer-review
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An explorative literature review of the multifactorial causes of osteoporosis in epilepsy
Diemar, S. S., Sejling, A. S., Eiken, P., Andersen, N. B. & Jørgensen, Niklas Rye, Nov 2019, In: Epilepsy and Behavior. 100, Part A, 10 p., 106511.Research output: Contribution to journal › Review › Research › peer-review
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The effect of normalization of sodium on bone turnover markers in patients with epilepsy. A randomized single-blinded placebo-controlled trial
Diemar, S. S., Jørgensen, Niklas Rye, Eiken, P., Suetta, Charlotte, Andersen, N. B. & Sejling, A., Sep 2020, In: Contemporary Clinical Trials Communications. 19, 8 p., 100587.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats
Diemar, S. S., Sejling, A. S., Eiken, P., Ellegaard, M., Ding, M., Andersen, N. B. & Jørgensen, Niklas Rye, 2020, In: Pharmacological Reports. 72, 5, p. 1323-1333 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of age and sex on osteocalcin and bone-specific alkaline phosphatase—reference intervals and confounders for two bone formation markers
Diemar, S. S., Møllehave, L. T., Quardon, N., Lylloff, L., Thuesen, B. H., Linneberg, Allan René & Jørgensen, Niklas Rye, Feb 2020, In: Archives of Osteoporosis. 15, 10 p., 26.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurement of amyloid-β 1-42 in cerebrospinal fluid: a comparison of the second generation Elecsys and INNOTEST
Dimopoulos, K., Simonsen, A. H., Gramkow, M. H., Schrøder, M., Jørgensen, Niklas Rye, Rode, L., Frikke-Schmidt, Ruth, Hilsted, Linda & Hasselbach, S. G., 2023, In: Clinical Chemistry and Laboratory Medicine. 61, 9, p. E182-E185 4 p.Research output: Contribution to journal › Comment/debate › Research
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New Emerging Biomarkers for Bone Disease: Sclerostin and Dickkopf-1 (DKK1)
Dincel, A. S., Jørgensen, Niklas Rye & on behalf of the IOF-IFCC Joint Committee on Bone Metabolism (C-BM), O. B. O. T. I. J. C. O. B. M. (., 2023, In: Calcified Tissue International. 112, p. 243–257Research output: Contribution to journal › Review › Research › peer-review
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Is sclerostin as bone marker ready for clinical use?
Dinçel, A. S. & Jørgensen, Niklas Rye, 2021, AACC Academy.Research output: Other contribution › Net publication - Internet publication › Research › peer-review
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Optimizing combination of vascular endothelial growth factor and mesenchymal stem cells on ectopic bone formation in SCID mice
Dreyer, C. H., Kjaergaard, K., Ditzel, N., Jørgensen, Niklas Rye, Overgaard, Søren & Ding, M., 2017, In: Journal of Biomedical Materials Research. Part A. 105, 12, p. 3326-3332Research output: Contribution to journal › Journal article › Research › peer-review
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Vascular Endothelial Growth Factor and Mesenchymal Stem Cells Revealed Similar Bone Formation to Allograft in a Sheep Model
Dreyer, C. H., Jørgensen, Niklas Rye, Overgaard, Søren, Qin, L. & Ding, M., 2021, In: BioMed Research International. 2021, 6676609.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypophosphatemic Hypovitaminosis D Induces Osteomalacia in the Adult Female Rat
Durup, D., Diaz-delCastillo, M., Morgenlykke, J., Jensen, Lars Thorbjørn, Frandsen, E., Abelson, Klas, Pedersen, L., Lykkesfeldt, Jens, Ding, M., Jørgensen, Niklas Rye, Syberg, S., Petersen, S. & Heegaard, Anne-Marie, 2020, In: Endocrinology. 161, 8, bqaa100.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors
Eickhoff, M. K., Dekkers, C. C. J., Kramers, B. J., Laverman, G. D., Frimodt-Møller, M., Jørgensen, Niklas Rye, Faber, Jens, Danser, A. H. J., Gansevoort, R. T., Rossing, Peter, Persson, F. & Heerspink, H. J. L., 31 May 2019, In: Journal of Clinical Medicine. 8, 6Research output: Contribution to journal › Journal article › Research › peer-review
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Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?
Ellegaard, M., Hegner, T., Ding, M., Ulmann, L. & Jørgensen, Niklas Rye, 2021, In: Purinergic Signalling. 17, p. 241–246Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients
Ellegaard, M., Bieler, T., Beyer, N., Kjær, Michael & Jørgensen, Niklas Rye, 2020, In: Translational Sports Medicine. 3, 1, p. 16-25Research output: Contribution to journal › Journal article › Research › peer-review
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Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor
Ellegaard, M., Agca, C., Petersen, S., Agrawal, A., Kruse, L. S., Wang, N., Gartland, A., Jensen, J. B., Jørgensen, Niklas Rye & Agca, Y., 2017, In: Purinergic Signalling. 13, 4, p. 545-557Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperglycaemia, diabetes and risk of fragility fractures: observational and Mendelian randomisation studies
Emanuelsson, F., Afzal, Shoaib, Jørgensen, Niklas Rye, Nordestgaard, Børge & Benn, Marianne, 2024, In: Diabetologia. 67, 2, p. 301-311 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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O12.4. EFFECTS OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST EXENATIDE ON BONE STATUS IN OBESE, NON-DIABETIC, ANTIPSYCHOTIC-TREATED SCHIZOPHRENIA SPECTRUM PATIENTS
Eriksson, R., Broberg, B. V., Ishoy, P. L., Bak, N., Andersen, U. B., Jørgensen, Niklas Rye, Knop, Filip Krag & Ebdrup, Bjørn, 2019, In: Schizophrenia Bulletin. 45, Suppl. 2, p. S198-S199 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study
Faurholt-Jepsen, M., Frøkjær, Vibe Gedsø, Nasser, A., Jørgensen, Niklas Rye, Kessing, Lars Vedel & Vinberg, Maj, Dec 2021, In: International Journal of Bipolar Disorders. 9, 1, 10 p., 8.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone Geometry, Density, and Microarchitecture in the Distal Radius and Tibia in Adults With Marfan Syndrome Assessed by HR-pQCT
Folkestad, L., Groth, K. A., Shanbhogue, V., Hove, H., Kyhl, K., Østergaard, J. R., Jørgensen, Niklas Rye, Andersen, N. H. & Gravholt, C. H., 2020, In: Journal of Bone and Mineral Research. 35, 12, p. 2335-2344Research output: Contribution to journal › Journal article › Research › peer-review
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Combinatorial, additive and dose-dependent drug–microbiome associations
Forslund, S. K., Chakaroun, R., Zimmermann-Kogadeeva, M., Markó, L., Aron-Wisnewsky, J., Nielsen, T., Moitinho-Silva, L., Schmidt, T. S. B., Falony, G., Vieira-Silva, S., Adriouch, S., Alves, R. J., Assmann, K., Bastard, J. P., Birkner, T., Caesar, R., Chilloux, J., Coelho, L. P., Fezeu, L., Galleron, N. & 23 others, , 2021, In: Nature. 600, p. 500-517 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 985846
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Characterization of pectin nanocoatings at polystyrene and titanium surfaces
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Kinetic [18F]-Fluoride of the Knee in Normal Volunteers
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The combined effect of Parathyroid hormone (1-34) and whole-body Vibration exercise in the treatment of postmenopausal OSteoporosis (PaVOS study): a randomized controlled trial
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