Skeletal muscle aging in the Kjær Group
In our group, we work with human and in vitro models to understand how physical activity and mechanical loading can influence both molecular reactions as well as structural adaptation of the musculotendinous tissue. We aim to pertubate the tissue homeostasis in skeletal muscle, tendon and cartilage in order to describe the adaptive responses both in regards to signaling, cell-cell interaction and protein turnover. This is done both in healthy individuals and in chronically diseased individuals. The investigations are done in close interaction with clinically handling of musculo-skeletal injuries in our out-patient clinic.
“Our group has a fascinating mixture of clinicians and researchers often combined in the same person. The interplay between MDs and non-MDs provided a fruitful research outcome,” says Professor and Group Leader Michael Kjær.
Over the last years, our group has contributed to demonstrate a much more dynamic tissue turnover in connective tissues, and pin pointed the detrimental effect upon those tissues with inactivity. Further, the loss of skeletal muscle with aging is explained by the reduced stem cell function, the increased inflammatory status and altered cell-cell interplay. Finally, we have proven that the optimal treatment of tendon overuse injuries is heavy resistance training and that regeneration of skeletal muscle after injury is dependent upon fast onset of rehabilitation.
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrityBasse, A. L., Agerholm, M., Farup, J., Dalbram, Emilie, Nielsen, J., Ørtenblad, N., Altıntaş, Ali, Ehrlich, Amy M, Krag, T., Bruzzone, S., Dall, Morten, de Guia, R. M., Jensen, J. B., Møller, A. B., Karlsen, A., Kjær, Michael, Barrès, Romain, Vissing, John, Larsen, Steen, Jessen, N. & Treebak, Jonas Thue, 2021, In: Molecular Metabolism. 53, 101271.
Chronic Sequelae After Muscle Strain Injuries: Influence of Heavy Resistance Training on Functional and Structural Characteristics in a Randomized Controlled TrialBayer, M. L., Hoegberget-Kalisz, M., Svensson, R. B., Hjortshoej, M. H., Olesen, J. L., Nybing, J. D., Boesen, Mikael Ploug, Magnusson, Stig Peter & Kjær, Michael, 2021, In: American Journal of Sports Medicine. 49, 10, p. 2783-2794 12 p.
Chronic hyperglycemia, hypercholesterolemia, and metabolic syndrome are associated with risk of tendon injurySkovgaard, D., Siersma, Volkert Dirk, Klausen, S. B., Visnes, H., Haukenes, I., Bang, Christine Winther, Bager, P., Gravare Silbernagel, K., Gaida, J., Magnusson, Stig Peter, Kjær, Michael & Couppé, Christian, 2021, In: Scandinavian Journal of Medicine & Science in Sports. 31, 9, p. 1822-1831 11 p.
Ongoing projects focus on:
1. Cellular interplay in the regeneration of muscle tissue in aging individuals
2. The hierarchical pathogenesis in tendon tissue with overloading
3. Healing of tendon tissue after rupture and cartilage dynamics in diseased joints
4. Influence of long-term physical training upon overall muscle and brain function with aging.