Simon Holst Bekker-Jensen

Simon Holst Bekker-Jensen

Professor

Member of:

ORCID: 0000-0002-7308-4597

Publication year:
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1 - 25 out of 78Page size: 25
  1. 2024
  2. Published

    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

    Xi, J., Snieckute, Goda, Martínez Hernández, José Francisco, Arendrup, Frederic Schrøder, Asthana, A., Gaughan, C., Lund, Anders H., Bekker-Jensen, Simon Holst & Silverman, R. H., 2024, In: Cell Reports. 43, 4, 20 p., 113998.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases

    Mordente, Kelly Christine, Jordan, Laura Ryder & Bekker-Jensen, Simon Holst, 2024, In: Molecular Cell. 84, 1, p. 142-155 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

    Rozario, P., Pinilla, M., Gorse, L., Vind, Anna Constance, Robinson, K. S., Toh, G. A., Firdaus, M. J., Martínez Hernández, José Francisco, Kerk, S. K., Lin, Z., Chambers, J. C., Bekker-Jensen, Simon Holst, Meunier, E. & Zhong, F., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 2, 12 p., e2309579121.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2023
  6. Published

    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

    López, A. R., Jørgensen, M. H., Havelund, J. F., Arendrup, Frederic Schrøder, Kolapalli, S. P., Nielsen, T. M., Pais, E., Beese, C. J., Abdul-Al, A., Vind, Anna Constance, Bartek, J., Bekker-Jensen, Simon Holst, Montes, M., Galanos, P., Faergeman, N., Happonen, L. & Frankel, Lisa, 2023, In: Cell Reports. 42, 11, 24 p., 113381.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Computational and Functional Analysis of Structural Features in the ZAKα Kinase

    Johansen, Valdemar Brimnes Ingemann, Snieckute, Goda, Vind, Anna Constance, Blasius, Melanie & Bekker-Jensen, Simon Holst, 2023, In: Cells. 12, 6, 969.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Myofibrillar myopathy hallmarks associated with ZAK deficiency

    Stonadge, A., Genzor Garbayo, Aitana Victoria, Russell, A., Hamed, M. F., Romero, N., Evans, G., Pownall, B., Bekker-Jensen, Simon Holst & Blanco, G., 2023, In: Human Molecular Genetics. 32, 17, p. 2751-2770 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms

    Jordan, Laura Ryder, Arendrup, Frederic Schrøder, Martínez, J. F., Snieckute, Goda, Pecorari, C., Shah, Riyaz, Lund, Anders H., Blasius, Melanie & Bekker-Jensen, Simon Holst, 2023, In: Cell Death & Disease. 14, 7, 10 p., 467.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    PRMT5-mediated regulatory arginine methylation of RIPK3

    Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

    Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 others, Lund, Anders H., Treebak, Jonas Thue, Olsen, Jesper Velgaard, Poulsen, Steen Seier, Pownall, M. E., Jensen, Benjamin Anderschou Holbech, Clemmensen, Christoffer, Gerhart-Hines, Zach, Gatfield, D. & Bekker-Jensen, Simon Holst, 2023, In: Science (New York, N.Y.). 382, 6675, 14 p., eadf3208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)

    Zhou, Y., Yu, H., Vind, Anna Constance, Kong, L., Liu, Y., Song, X., Tu, Z., Yun, C., Smaill, J. B., Zhang, Q. W., Ding, K., Bekker-Jensen, Simon Holst & Lu, X., 2023, In: Journal of Medicinal Chemistry. 66, 11, p. 7405–7420

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Run, Ribosome, Run: From Compromised Translation to Human Health

    Vind, Anna Constance, Snieckute, Goda, Bekker-Jensen, Simon Holst & Blasius, Melanie, 2023, In: Antioxidants & Redox Signaling. 39, 4-6, p. 336-350 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. 2022
  15. Published

    Meeting Report: Aging Research and Drug Discovery

    Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., Fortney, K. & 58 others, Freund, A., Georgievskaya, A., Gladyshev, V. N., Glass, D., Golato, T., Gorbunova, V., Hoejimakers, J., Houtkooper, R. H., Jager, S., Jaksch, F., Janssens, G., Jensen, M. B., Kaeberlein, M., Karsenty, G., de Keizer, P., Kennedy, B., Kirkland, J. L., Kjær, Michael, Kroemer, G., Lee, K. F., Lemaitre, J. M., Liaskos, D., Longo, V. D., Lu, Y. X., MacArthur, M. R., Maier, A. B., Manakanatas, C., Mitchell, S. J., Moskalev, A., Niedernhofer, L., Ozerov, I., Partridge, L., Passegué, E., Petr, Michael Angelo, Peyer, J., Radenkovic, D., Rando, T. A., Rattan, S., Riedel, C. G., Rudolph, L., Ai, R., Serrano, M., Schumacher, B., Sinclair, D. A., Smith, R., Suh, Y., Taub, P., Trapp, A., Trendelenburg, A. U., Valenzano, D. R., Verburgh, K., Verdin, E., Vijg, J., Westendorp, Rudi GJ, Zonari, A., Bakula, Daniela Janina, Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2022, In: Aging. 14, 2, p. 530-543 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

    Silva, J., Alkan, F., Ramalho, S., Snieckute, Goda, Prekovic, S., Garcia, A. K., Hernández-Pérez, S., van der Kammen, R., Barnum, D., Hoekman, L., Altelaar, M., Zwart, W., Suijkerbuijk, S. J. E., Bekker-Jensen, Simon Holst & Faller, W. J., 2022, In: Nature Communications. 13, 1, 4492.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

    Snieckute, Goda, Genzor Garbayo, Aitana Victoria, Vind, Anna Constance, Jordan, Laura Ryder, Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, Frederike, Blasius, Melanie, López, A. R., Brynjólfsdóttir, S. H., Andersen, Kasper Langebjerg, Willis, A. E., Frankel, Lisa, Poulsen, Steen Seier, Gatfield, D., Gerhart-Hines, Zach, Clemmensen, Christoffer & Bekker-Jensen, Simon Holst, 2022, In: Cell Metabolism. 34, 12, p. 2036-2046.e8 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

    Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, Mallein-Gerin, F., Andersen, J. L., Pennisi, C. P., Clemmensen, Christoffer, Kassem, Moustapha Saad El-Deen, Jafari Kermani, Abbas, Brummelkamp, T., Li, V. S., Wickström, S. A., Olsen, Jesper Velgaard, Blanco, G. & Bekker-Jensen, Simon Holst, 2022, In: E M B O Journal. 41, 17, 19 p., e111650.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2021
  20. Published

    Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution

    Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2 Feb 2021, bioRxiv, p. 1-34, 34 p.

    Research output: Working paper › Preprint › Research

  21. Published

    Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses

    Nordgaard, C., Tollenaere, M. A. X., Martinez Del Val, Ana, Bekker-Jensen, D. B., Blasius, Melanie, Olsen, Jesper Velgaard & Bekker-Jensen, Simon Holst, 2021, In: International Journal of Molecular Sciences. 22, 17, 23 p., 9595.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution

    Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Koenig, Claire, Østergaard, Ole, Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2021, In: Nature Communications. 12, 1, 17 p., 7113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2020
  24. Published

    Ribosomal stress-surveillance: three pathways is a magic number

    Vind, Anna Constance, Genzor Garbayo, Aitana Victoria & Bekker-Jensen, Simon Holst, 2020, In: Nucleic Acids Research. 48, 19, p. 10648-10661 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains

    Vind, Anna Constance, Snieckute, Goda, Blasius, Melanie, Tiedje, C., Krogh, Nicolai, Bekker-Jensen, D. B., Andersen, Kasper Langebjerg, Nordgaard, C., Tollenaere, M. A. X., Lund, Anders H., Olsen, Jesper Velgaard, Nielsen, Henrik & Bekker-Jensen, Simon Holst, 2020, In: Molecular Cell. 78, 4, p. 700-713.E7

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2019
  27. Published

    Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

    Trulley, P., Snieckute, Goda, Bekker-Jensen, D., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2019, In: Cell Reports. 27, 10, p. 2859-2870.e6 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

    Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation

    Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

    Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M. & 8 others, Andersen, J. S., Bekker-Jensen, Simon Holst, Lund, Anders H., Rogov, V. V., Papaleo, E., Lanzetti, L., De Zio, D. & Cecconi, F., 2019, In: Nature Communications. 10, 1, p. 1-19 19 p., 4176.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

    Ronkina, N., Shushakova, N., Tiedje, C., Yakovleva, T., Tollenaere, M. A. X., Scott, A., Batth, Tanveer Singh, Olsen, Jesper Velgaard, Helmke, A., Bekker-Jensen, Simon Holst, Clark, A. R., Kotlyarov, A. & Gaestel, M., 2019, In: Journal of immunology (Baltimore, Md. : 1950). 203, 8, p. 2291-2300 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 14470936