Simon Holst Bekker-Jensen

Simon Holst Bekker-Jensen

Professor

Member of:

ORCID: 0000-0002-7308-4597

Publication year:
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1 - 78 out of 78Page size: 100
  1. 2024
  2. Published

    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

    Xi, J., Snieckute, Goda, Martínez Hernández, José Francisco, Arendrup, Frederic Schrøder, Asthana, A., Gaughan, C., Lund, Anders H., Bekker-Jensen, Simon Holst & Silverman, R. H., 2024, In: Cell Reports. 43, 4, 20 p., 113998.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases

    Mordente, Kelly Christine, Jordan, Laura Ryder & Bekker-Jensen, Simon Holst, 2024, In: Molecular Cell. 84, 1, p. 142-155 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

    Rozario, P., Pinilla, M., Gorse, L., Vind, Anna Constance, Robinson, K. S., Toh, G. A., Firdaus, M. J., Martínez Hernández, José Francisco, Kerk, S. K., Lin, Z., Chambers, J. C., Bekker-Jensen, Simon Holst, Meunier, E. & Zhong, F., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 2, 12 p., e2309579121.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2023
  6. Published

    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

    López, A. R., Jørgensen, M. H., Havelund, J. F., Arendrup, Frederic Schrøder, Kolapalli, S. P., Nielsen, T. M., Pais, E., Beese, C. J., Abdul-Al, A., Vind, Anna Constance, Bartek, J., Bekker-Jensen, Simon Holst, Montes, M., Galanos, P., Faergeman, N., Happonen, L. & Frankel, Lisa, 2023, In: Cell Reports. 42, 11, 24 p., 113381.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Computational and Functional Analysis of Structural Features in the ZAKα Kinase

    Johansen, Valdemar Brimnes Ingemann, Snieckute, Goda, Vind, Anna Constance, Blasius, Melanie & Bekker-Jensen, Simon Holst, 2023, In: Cells. 12, 6, 969.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Myofibrillar myopathy hallmarks associated with ZAK deficiency

    Stonadge, A., Genzor Garbayo, Aitana Victoria, Russell, A., Hamed, M. F., Romero, N., Evans, G., Pownall, B., Bekker-Jensen, Simon Holst & Blanco, G., 2023, In: Human Molecular Genetics. 32, 17, p. 2751-2770 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms

    Jordan, Laura Ryder, Arendrup, Frederic Schrøder, Martínez, J. F., Snieckute, Goda, Pecorari, C., Shah, Riyaz, Lund, Anders H., Blasius, Melanie & Bekker-Jensen, Simon Holst, 2023, In: Cell Death & Disease. 14, 7, 10 p., 467.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    PRMT5-mediated regulatory arginine methylation of RIPK3

    Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

    Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 others, Lund, Anders H., Treebak, Jonas Thue, Olsen, Jesper Velgaard, Poulsen, Steen Seier, Pownall, M. E., Jensen, Benjamin Anderschou Holbech, Clemmensen, Christoffer, Gerhart-Hines, Zach, Gatfield, D. & Bekker-Jensen, Simon Holst, 2023, In: Science (New York, N.Y.). 382, 6675, 14 p., eadf3208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)

    Zhou, Y., Yu, H., Vind, Anna Constance, Kong, L., Liu, Y., Song, X., Tu, Z., Yun, C., Smaill, J. B., Zhang, Q. W., Ding, K., Bekker-Jensen, Simon Holst & Lu, X., 2023, In: Journal of Medicinal Chemistry. 66, 11, p. 7405–7420

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Run, Ribosome, Run: From Compromised Translation to Human Health

    Vind, Anna Constance, Snieckute, Goda, Bekker-Jensen, Simon Holst & Blasius, Melanie, 2023, In: Antioxidants & Redox Signaling. 39, 4-6, p. 336-350 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. 2022
  15. Published

    Meeting Report: Aging Research and Drug Discovery

    Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., Fortney, K. & 58 others, Freund, A., Georgievskaya, A., Gladyshev, V. N., Glass, D., Golato, T., Gorbunova, V., Hoejimakers, J., Houtkooper, R. H., Jager, S., Jaksch, F., Janssens, G., Jensen, M. B., Kaeberlein, M., Karsenty, G., de Keizer, P., Kennedy, B., Kirkland, J. L., Kjær, Michael, Kroemer, G., Lee, K. F., Lemaitre, J. M., Liaskos, D., Longo, V. D., Lu, Y. X., MacArthur, M. R., Maier, A. B., Manakanatas, C., Mitchell, S. J., Moskalev, A., Niedernhofer, L., Ozerov, I., Partridge, L., Passegué, E., Petr, Michael Angelo, Peyer, J., Radenkovic, D., Rando, T. A., Rattan, S., Riedel, C. G., Rudolph, L., Ai, R., Serrano, M., Schumacher, B., Sinclair, D. A., Smith, R., Suh, Y., Taub, P., Trapp, A., Trendelenburg, A. U., Valenzano, D. R., Verburgh, K., Verdin, E., Vijg, J., Westendorp, Rudi GJ, Zonari, A., Bakula, Daniela Janina, Zhavoronkov, A. & Scheibye-Knudsen, Morten, 2022, In: Aging. 14, 2, p. 530-543 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

    Silva, J., Alkan, F., Ramalho, S., Snieckute, Goda, Prekovic, S., Garcia, A. K., Hernández-Pérez, S., van der Kammen, R., Barnum, D., Hoekman, L., Altelaar, M., Zwart, W., Suijkerbuijk, S. J. E., Bekker-Jensen, Simon Holst & Faller, W. J., 2022, In: Nature Communications. 13, 1, 4492.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

    Snieckute, Goda, Genzor Garbayo, Aitana Victoria, Vind, Anna Constance, Jordan, Laura Ryder, Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, Frederike, Blasius, Melanie, López, A. R., Brynjólfsdóttir, S. H., Andersen, Kasper Langebjerg, Willis, A. E., Frankel, Lisa, Poulsen, Steen Seier, Gatfield, D., Gerhart-Hines, Zach, Clemmensen, Christoffer & Bekker-Jensen, Simon Holst, 2022, In: Cell Metabolism. 34, 12, p. 2036-2046.e8 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

    Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, Mallein-Gerin, F., Andersen, J. L., Pennisi, C. P., Clemmensen, Christoffer, Kassem, Moustapha Saad El-Deen, Jafari Kermani, Abbas, Brummelkamp, T., Li, V. S., Wickström, S. A., Olsen, Jesper Velgaard, Blanco, G. & Bekker-Jensen, Simon Holst, 2022, In: E M B O Journal. 41, 17, 19 p., e111650.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2021
  20. Published

    Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution

    Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2 Feb 2021, bioRxiv, p. 1-34, 34 p.

    Research output: Working paper › Preprint › Research

  21. Published

    Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses

    Nordgaard, C., Tollenaere, M. A. X., Martinez Del Val, Ana, Bekker-Jensen, D. B., Blasius, Melanie, Olsen, Jesper Velgaard & Bekker-Jensen, Simon Holst, 2021, In: International Journal of Molecular Sciences. 22, 17, 23 p., 9595.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution

    Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Koenig, Claire, Østergaard, Ole, Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2021, In: Nature Communications. 12, 1, 17 p., 7113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2020
  24. Published

    Ribosomal stress-surveillance: three pathways is a magic number

    Vind, Anna Constance, Genzor Garbayo, Aitana Victoria & Bekker-Jensen, Simon Holst, 2020, In: Nucleic Acids Research. 48, 19, p. 10648-10661 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains

    Vind, Anna Constance, Snieckute, Goda, Blasius, Melanie, Tiedje, C., Krogh, Nicolai, Bekker-Jensen, D. B., Andersen, Kasper Langebjerg, Nordgaard, C., Tollenaere, M. A. X., Lund, Anders H., Olsen, Jesper Velgaard, Nielsen, Henrik & Bekker-Jensen, Simon Holst, 2020, In: Molecular Cell. 78, 4, p. 700-713.E7

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2019
  27. Published

    Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

    Trulley, P., Snieckute, Goda, Bekker-Jensen, D., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2019, In: Cell Reports. 27, 10, p. 2859-2870.e6 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

    Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In: Cell Reports. 26, 13, p. 3511-3521.e4 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation

    Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

    Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M. & 8 others, Andersen, J. S., Bekker-Jensen, Simon Holst, Lund, Anders H., Rogov, V. V., Papaleo, E., Lanzetti, L., De Zio, D. & Cecconi, F., 2019, In: Nature Communications. 10, 1, p. 1-19 19 p., 4176.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

    Ronkina, N., Shushakova, N., Tiedje, C., Yakovleva, T., Tollenaere, M. A. X., Scott, A., Batth, Tanveer Singh, Olsen, Jesper Velgaard, Helmke, A., Bekker-Jensen, Simon Holst, Clark, A. R., Kotlyarov, A. & Gaestel, M., 2019, In: Journal of immunology (Baltimore, Md. : 1950). 203, 8, p. 2291-2300 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2018
  33. Published

    p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

    Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

    Trulley, P., Snieckute, Goda, Bekker-Jensen, D. B., Menon, M. B., Freund, R., Kotlyarov, A., Olsen, Jesper Velgaard, Diaz-Muñoz, M. D., Turner, M., Bekker-Jensen, Simon Holst, Gaestel, M. & Tiedje, C., 2018, bioRxiv, 46 p. (bioRxiv).

    Research output: Working paper › Preprint › Research

  35. Published

    Osmotic Stress Blocks Mobility and Dynamic Regulation of Centriolar Satellites

    Nielsen, J. C., Nordgaard, C., Tollenaere, M. A. X. & Bekker-Jensen, Simon Holst, 2018, In: Cells. 7, 7, 20 p., 65.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2016
  37. Published

    SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

    Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N. & 1 others, Bekker-Jensen, Simon Holst, 7 Nov 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366

    Research output: Contribution to journal › Letter › Research › peer-review

  38. Published

    Activation of the ATR kinase by the RPA-binding protein ETAA1

    Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In: Nature. 534, 7609, p. 714-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO

    Diehl, C., Akke, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Streicher, W. & Wikström, M., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

    Schwertman, P., Bekker-Jensen, Simon Holst & Mailand, Niels, Jun 2016, In: Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

    Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling

    Airik, R., Schueler, M., Airik, M., Cho, J., Ulanowicz, K. A., Porath, J. D., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Andersen, J. S. & Hildebrandt, F., 2016, In: P L o S One. 11, 5, 19 p., e0156081.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. 2015
  45. Published

    p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

    Tollenaere, M. A. X., Villumsen, B. H., Blasius, M., Nielsen, J. C., Wagner, S. A., Bartek, J., Beli, P., Mailand, Niels & Bekker-Jensen, Simon Holst, 30 Nov 2015, In: Nature Communications. 6, p. 1-12 12 p., 10075.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In: Nature. 527, 7578, p. 389-93 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  47. Published

    RNF138 joins the HR team

    Bekker-Jensen, Simon Holst & Mailand, Niels, Oct 2015, In: Nature Cell Biology. 17, 11, p. 1375-7 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway

    Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In: E M B O Journal. 34, p. 1385-1398

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

    Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, Simon Holst, Mailand, Niels & Hutchison, C. J., Apr 2015, In: Aging Cell. 14, 2, p. 162-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Centriolar satellites: key mediators of centrosome functions

    Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In: Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  51. Published

    Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

    Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

    Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In: Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2014
  55. Published

    Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling

    Airik, R., Slaats, G. G., Guo, Z., Weiss, A., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R. H. & Hildebrandt, F., Nov 2014, In: Journal of the American Society of Nephrology:JASN. 25, 11, p. 2573-83 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

    Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chunaram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In: E M B O Reports. 15, 9, p. 956-964 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. 2013
  58. Published

    ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

    Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chunaram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In: E M B O Journal. 32, 23, p. 3029-3040

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

    Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

    Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

    Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chunaram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In: Journal of Cell Biology. 201, 6, p. 797-807 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Regulation of PCNA-protein interactions for genome stability

    Mailand, Niels, Gibbs-Seymour, I. & Bekker-Jensen, Simon Holst, May 2013, In: Nature Reviews. Molecular Cell Biology. 14, 5, p. 269-82 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

    Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. 2012
  66. Published

    Histone displacement during nucleotide excision repair

    Dinant, C., Bartek, J. & Bekker-Jensen, Simon Holst, 17 Oct 2012, In: International Journal of Molecular Sciences (Online). 13, 10, p. 13322-13337 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

    Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chunaram, Oct 2012, In: Nature Cell Biology. 14, 10, p. 1089-98 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Ubiquitin and the DNA damage response: a new handle on histones

    Bekker-Jensen, Simon Holst & Mailand, Niels, 1 Sep 2012, In: Cell Cycle. 11, 17, p. 3153 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  69. Published

    TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

    Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

    Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

    Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

    Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 189-99 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    ICLs: a chicken without an egg

    Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Reviews. Molecular Cell Biology. 13, 6, p. 342

    Research output: Contribution to journal › Review › Research › peer-review

  75. Published

    RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

    Østergaard, Vibe Hallundbæk, Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, Simon Holst, Mailand, Niels & Lisby, Michael, 2012, In: D N A Repair. 11, 11, p. 892–905 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. 2011
  78. Published

    The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

    Bekker-Jensen, Simon Holst & Mailand, Niels, 12 Jun 2011, In: FEBS Letters. 585, p. 2914-2919 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  79. Published

    53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

    Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

    Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. 2010
  82. Published

    Assembly and function of DNA double-strand break repair foci in mammalian cells

    Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

    Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12

    Research output: Contribution to journal › Letter › Research › peer-review

  84. 2009
  85. Published

    Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

    Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, Simon Holst, Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, Jiri & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

    Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

    Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In: Cell. 136, 3, p. 435-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

    Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. 2008

  90. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

    Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. 2007
  92. Published

    Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

    Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

    Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. 2006

  95. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

    Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

    Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 14470936