Cellular stress signalling in the Bekker-Jensen Group

Our primary goal is to understand the contribution of cellular stress signalling pathways to a range of human diseases and aging processes. Our emphasis is on obtaining a deep mechanistic insight, while exploring opportunities for clinical translation of our findings.

Cellular stress signalling in the Bekker-Jensen Group

Research focus

The overarching aim for our group is to understand the molecular details of cellular stress responses and how they contribute to human diseases such as cancer and aging-related maladies. We are especially interested in understanding the mechanisms by which the MAP kinases p38 and JNK become activated in response to cellular stress insults such as ribosomal impairment, oxidative stress and high osmolarity, and how such signaling drives or protect against pathological cellular changes. Importantly, the same signaling pathways are crucial for inflammatory responses, adding to the relevance of our work for a range of human diseases.

“The physiological and pathological outcomes of cellular stress signalling remain under-appreciated. I believe there is still much to be learned, and that our work can lead to medical breakthroughs,“ says Professor and Group Leader, Simon Bekker-Jensen.