Sports-related concussion is difficult to diagnose due to the lack of objective biomarkers. Another difficult diagnosis is chronic traumatic encephalopathy (CTE), which is currently set by a neuropathological examination at autopsy. This review aims to give an overview of potential biomarkers in the acute and chronic phase. Biomarkers for the acute phase consist of both MRI and blood markers. Variable biomarkers are studied for CTE, and PET/CT imaging taupathy shows great potential. Further studies are required for validating literature on biomarkers.