Ian David Hickson

Ian David Hickson

Professor

Member of:


  1. 2024
  2. Published

    PICH deficiency limits the progression of MYC-induced B-cell lymphoma

    Castejón-Griñán, M., Albers, E., Simón-Carrasco, L., Aguilera, P., Sbroggio, M., Pladevall Morera, David, Ingham, Andreas, Lim, Ernest Wee Kiat, Guillen-Benitez, A., Pietrini, E., Lisby, Michael, Hickson, Ian David & Lopez-Contreras, Andres, 2024, In: Blood Cancer Journal. 14, 1, 15 p., 16.

    Research output: Contribution to journalJournal articlepeer-review

  3. 2023
  4. Published

    BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures

    Danino, Y. M., Molitor, L., Rosenbaum-Cohen, T., Kaiser, Sebastian, Cohen, Y., Porat, Z., Marmor-Kollet, H., Katina, C., Savidor, A., Rotkopf, R., Ben-Isaac, E., Golani, O., Levin, Y., Monchaud, D., Hickson, Ian David & Hornstein, E., 2023, In: Nucleic Acids Research. 51, 17, p. 9369-9384 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Completing genome replication outside of S phase

    Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2023, In: Molecular Cell. 83, 20, p. 3596-3607 12 p.

    Research output: Contribution to journalReviewpeer-review

  6. Published

    Cyclin E overexpression in the Drosophila accessory gland induces tissue dysplasia

    Molano-Fernández, M., Hickson, Ian David & Herranz, Hector, 2023, In: Frontiers in Cell and Developmental Biology. 10, 992253.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

    Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Viscoelastic Capillary Flow Cytometry

    Serhatlioglu, M., Jensen, E. A., Niora, M., Hansen, A. T., Nielsen, Christian Friberg, Jansman, M. M. T., Hosta-rigau, L., Dziegiel, Morten Hanefeld, Berg-sørensen, K., Hickson, Ian David & Kristensen, A., 2023, In: Advanced NanoBiomed Research. 3, 2, 2200137.

    Research output: Contribution to journalJournal articlepeer-review

  9. 2022
  10. Published

    Development of a fiber-based microfluidic flow cytometry platform using viscoelastic fluids for polydisperse particle suspensions

    Serhatlioglu, M., Jensen, E. A., Niora, M., Hansen, A. T., Nielsen, Christian Friberg, Theresia Jansman, M. M., Hosta-Rigau, L., Dziegiel, Morten Hanefeld, Berg-Sørensen, K., Hickson, Ian David & Kristensen, A., 2022, In: Proceedings of SPIE - The International Society for Optical Engineering. 12198, 9 p., 1219802.

    Research output: Contribution to journalConference articlepeer-review

  11. Published

    Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

    Bakx, J. A. M., Biebricher, A. S., King, G. A., Christodoulis, P., Sarlós, K., Bizard, A. H., Hickson, Ian David, Wuite, G. J. L. & Peterman, E. J. G., 2022, In: Nature Communications. 13, 1, 584.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation

    Vajen, B., Bhowmick, Rahul, Greiwe, L., Schäffer, V., Eilers, M., Reinkens, T., Stalke, A., Schmidt, G., Fiedler, J., Thum, T., Deluca, D. S., Hickson, Ian David, Schlegelberger, B., Illig, T. & Skawran, B., 2022, In: International Journal of Molecular Sciences. 23, 9, 5131.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Nonlinear mechanics of human mitotic chromosomes

    Meijering, A. E. C., Sarlós, K., Nielsen, Christian Friberg, Witt, H., Harju, J., Kerklingh, E., Haasnoot, G. H., Bizard, A. H., Heller, I., Broedersz, C. P., Liu, Ying, Peterman, E. J. G., Hickson, Ian David & Wuite, G. J. L., 2022, In: Nature. p. 545–550

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response

    Geng, X., Zhang, C., Li, M., Wang, J., Ji, F., Feng, H., Xing, M., Li, F., Zhang, L., Li, W., Chen, Z., Hickson, Ian David, Shen, H. & Ying, S., 2022, In: Advanced Science. 9, 7, 2103837.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    PICH acts as a force-dependent nucleosome remodeler

    Spakman, D., Clement, T. V. M., Biebricher, A. S., King, G. A., Singh, Manika Indrajit, Hickson, Ian David, Peterman, E. J. G. & Wuite, G. J. L., 2022, In: Nature Communications. 13, 7277.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    RAD51 protects human cells from transcription-replication conflicts

    Bhowmick, Rahul, Lerdrup, Mads, Gadi, Sampath Amitash, Rossetti, G. G., Singh, Manika Indrajit, Liu, Ying, Halazonetis, T. D. & Hickson, Ian David, 2022, In: Molecular Cell. 82, 18, p. 3366-3381.e9

    Research output: Contribution to journalJournal articlepeer-review

  17. 2020
  18. Published

    Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

    Garribba, L., Bjerregaard, V. A., Gonçalves Dinis, M. M., Özer, Ö., Wu, Wei, Sakellariou, D., Pena-Diaz, J., Hickson, Ian David & Liu, Ying, 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 28, p. 16527-16536 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

    Macheret, M., Bhowmick, Rahul, Sobkowiak, K., Padayachy, L., Mailler, J., Hickson, Ian David & Halazonetis, T. D., 2020, In: Cell Research. 30, p. 997–1008

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

    Venegas, A. B., Natsume, T., Kanemaki, M. & Hickson, Ian David, 2020, In: Cell Reports. 31, 3, 20 p., 107533.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

    Wu, Wei, Bhowmick, Rahul, Vogel, Ivan, Özer, Ö., Ghisays, F., Thakur, R. S., Sanchez de Leon, E., Richter, P. H., Ren, L., Petrini, J. H., Hickson, Ian David & Liu, Ying, 2020, In: Nature Structural & Molecular Biology. 27, 5, p. 424-437 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

    Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Ying, Hickson, Ian David, Shen, H. & Ying, S., 2020, In: Molecular Cell. 78, 4, p. 714-724.e5

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

    Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, Smaragda, Simonsen, Anne Katrine Wrist, Viswalingam, K. S., Gonzalez, L., Hickson, Ian David, Østergaard, Vibe Hallundbæk, Mankouri, H. W., Sung, P. & Lisby, Michael, 2020, In: Cell Reports. 32, 1, 25 p., 107849.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    The many lives of type IA topoisomerases

    Bizard, A. H. & Hickson, Ian David, 2020, In: Journal of Biological Chemistry. 295, 20, p. 7138-7153 16 p.

    Research output: Contribution to journalReviewpeer-review

  26. Published

    The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells

    Wu, Wei, Hickson, Ian David & Liu, Ying, 2020, In: Genome Instability & Disease. 1, 3, p. 114–128 15 p.

    Research output: Contribution to journalReviewpeer-review

  27. Published

    Tumour predisposition and cancer syndromes as models to study gene–environment interactions

    Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I. & 3 others, Petrini, J. H., Schmidt, L. S. & Yang, H., 2020, In: Nature Reviews Cancer. 20, p. 533–549

    Research output: Contribution to journalJournal articlepeer-review

  28. 2019
  29. Published

    Chromosome instability syndromes

    Taylor, A. M. R., Rothblum-Oviatt, C., Ellis, N. A., Hickson, Ian David, Meyer, S., Crawford, T. O., Smogorzewska, A., Pietrucha, B., Weemaes, C. & Stewart, G. S., 2019, In: Nature Reviews. Disease Primers. 5, 20 p., 64.

    Research output: Contribution to journalReviewpeer-review

  30. Published

    DNA replication stress and its impact on chromosome segregation and tumorigenesis

    Zhang, B. N., Bueno Venegas, A., Hickson, Ian David & Chu, W. K., 2019, In: Seminars in Cancer Biology. 55, p. 61-69

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Esc2 promotes telomere stability in response to DNA replication stress

    Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    PICH and TOP3A cooperate to induce positive DNA supercoiling

    Bizard, A. H., Allemand, J. F., Hassenkam, Tue, Paramasivam, M., Sarlós, K., Singh, Manika Indrajit & Hickson, Ian David, 2019, In: Nature Structural and Molecular Biology. 26, 4, p. 267-274 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

    Achuthankutty, D., Thakur, R. S., Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, A. H., Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In: The Journal of Cell Biology. 218, 12, 11 p., 3943.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Sonneville, R., Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian David & Labib, K., 2019, In: eLife. 8, 19 p., e48686.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

    Bhowmick, Rahul, Thakur, R. S., Venegas, A. B., Liu, Ying, Nilsson, Jakob, Barisic, Marin & Hickson, Ian David, 2019, In: Current Biology. 29, 7, p. 1232-1242.e5

    Research output: Contribution to journalJournal articlepeer-review

  36. 2018
  37. Published

    Anaphase: a fortune-teller of genomic instability

    Bizard, A. H. & Hickson, Ian David, Jun 2018, In: Current Opinion in Cell Biology. 52, p. 112-119 8 p.

    Research output: Contribution to journalReviewpeer-review

  38. Published

    A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation

    Larsen, N. B., Hickson, Ian David & Mankouri, H. W., 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 295-309 15 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  39. Published

    Detection of Ultrafine Anaphase Bridges

    Bizard, A. H., Nielsen, Christian Friberg & Hickson, Ian David, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 495-508 14 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  40. Published

    Folate deficiency drives mitotic missegregation of the human FRAXA locus

    Bjerregaard, V. A., Garribba, L., McMurray, C. T., Hickson, Ian David & Liu, Ying, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. 13003-13008 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism

    Özer, Ö., Bhowmick, Rahul, Liu, Ying & Hickson, Ian David, 2018, In: OncoTarget. 9, 22, p. 15836-15846 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci

    Garribba, L., Wu, Wei, Özer, Ö., Bhowmick, Rahul, Hickson, Ian David & Liu, Ying, 2018, Methods in Enzymology: Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Spies, M. & Malkova, A. (eds.). Elsevier, Vol. 601. p. 45-58 14 p. (Methods in Enzymology; No. 601).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  43. Published

    Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality

    Albers, E., Sbroggiò, M., Pladevall Morera, David, Bizard, A. H., Avram, Alexandra Ioana, Gonzalez, P., Martin Gonzalez, Javier, Hickson, Ian David & Lopez-Contreras, Andres, 2018, In: Cell Reports. 24, 12, p. 3274-3284 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Mutations in TOP3A Cause a Bloom Syndrome-like Disorder

    GOSgene, G., 2018, In: American Journal of Human Genetics. 103, 2, p. 221-231 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Pathways for maintenance of telomeres and common fragile sites during DNA replication stress

    Özer, Ö. & Hickson, Ian David, 2018, In: Open Biology. 8, 4, 11 p., 180018.

    Research output: Contribution to journalReviewpeer-review

  46. Published

    Reconstitution of anaphase DNA bridge recognition and disjunction

    Sarlós, K., Biebricher, A. S., Bizard, A. H., Bakx, J. A. M., Ferreté-Bonastre, A. G., Modesti, M., Paramasivam, M., Yao, Q., Peterman, E. J. G., Wuite, G. J. L. & Hickson, Ian David, 2018, In: Nature Structural and Molecular Biology. 25, 9, p. 868-876 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    The Detection and Analysis of Chromosome Fragile Sites

    Bjerregaard, V. A., Özer, Ö., Hickson, Ian David & Liu, Ying, 2018, Genome Instability: Methods and Protocols. Springer, Vol. 1672. p. 471-482 12 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  48. 2017
  49. Published

    RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

    Di Marco, S., Hasanova, Z., Kanagaraj, R., Chappidi, N., Altmannova, V., Menon, S., Sedlackova, H., Langhoff, J., Surendranath, K., Hühn, D., Bhowmick, Rahul, Marini, V., Ferrari, S., Hickson, Ian David, Krejci, L. & Janscak, P., 1 Jun 2017, In: Molecular Cell. 66, 5, p. 658-671.e8

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    A novel TPR-BEN domain interaction mediates PICH-BEND3 association

    Pitchai, G. P., Kaulich, M., Bizard, A. H., Mesa, Pablo, Yao, Q., Sarlos, K., Streicher, W. W., Nigg, E. A., Montoya, Guillermo & Hickson, Ian David, 2017, In: Nucleic Acids Research. 19, 2, p. 11413–11424

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis

    Natsume, T., Nishimura, K., Minocherhomji, S., Bhowmick, Rahul, Hickson, Ian David & Kanemaki, M. T., 2017, In: Genes & Development. 31, 8, p. 816-829 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells

    Kessler, B. M., Bursomanno, S., McGouran, J. F., Hickson, Ian David & Liu, Ying, 2017, Activity-Based Proteomics: Methods and Protocols. Overkleeft, H. S. & Florea, B. I. (eds.). Humana Press, Vol. 1491. p. 131-144 14 p. (Methods in Molecular Biology, Vol. 1491).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  53. Published

    Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase

    Sarlós, K., Biebricher, A., Petermann, E. J. G., Wuite, G. J. L. & Hickson, Ian David, 2017, In: Cold Spring Harbor Laboratory. Symposia on Quantitative Biology. 82, p. 187-195

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Potential biomarkers of DNA replication stress in cancer

    Ren, L., Chen, L., Wu, Wei, Garribba, L., Tian, H., Liu, Z., Vogel, Ivan, Li, C., Hickson, Ian David & Liu, Ying, 2017, In: OncoTarget. 8, 23, p. 36996-37008 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Stalled replication forks generate a distinct mutational signature in yeast

    Larsen, N. B., Liberti, S. E., Vogel, Ivan, Jorgensen, S. W., Hickson, Ian David & Mankouri, H. W., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. 9665-9670

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    The "enemies within": regions of the genome that are inherently difficult to replicate

    Bhowmick, Rahul & Hickson, Ian David, 2017, In: F1000Research. 6, 7 p., 666.

    Research output: Contribution to journalReviewpeer-review

  57. 2016
  58. Published

    RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

    Bhowmick, Rahul, Minocherhomji, S. & Hickson, Ian David, 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1117-1126 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction

    Nielsen, Christian Friberg & Hickson, Ian David, 17 Oct 2016, In: Cell Cycle. 15, 20, p. 2704-2711 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

    Ghamrasni, S. E., Cardoso, R., Li, L., Guturi, K. K. N., Bjerregaard, V. A., Liu, Ying, Venkatesan, S., Hande, M. P., Henderson, J. T., Sanchez, O., Hickson, Ian David, Hakem, A. & Hakem, R., 15 Sep 2016, In: Oncogene. 35, 37, p. 4836-4845 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Published

    Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

    Pitchai, G. P., Hickson, Ian David, Streicher, W., Montoya, Guillermo & Mesa, Pablo, Aug 2016, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 72, 8, p. 646-651 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

    Ahuja, A. K., Jodkowska, K., Teloni, F., Bizard, A. H., Zellweger, R., Herrador, R., Ortega, S., Hickson, Ian David, Altmeyer, M., Mendez, J. & Lopes, M., Feb 2016, In: Nature Communications. 7, 11 p., 10660.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published
  64. 2015
  65. Published

    Replication stress activates DNA repair synthesis in mitosis

    Minocherhomji, S., Ying, S., Bjerregaard, V. A., Bursomanno, S., Aleliunaite, A., Wu, Wei, Mankouri, H. W., Shen, H., Liu, Ying & Hickson, Ian David, 10 Dec 2015, In: Nature. 528, 7581, p. 286-90 5 p.

    Research output: Contribution to journalLetterpeer-review

  66. Published

    Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

    Kliszczak, M., Sedlackova, H., Pitchai, G. P., Streicher, W. W., Krejci, L. & Hickson, Ian David, 1 Dec 2015, In: OncoTarget. 6, 38, p. 40464-79 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    FBH1 Catalyzes Regression of Stalled Replication Forks

    Fugger, K., Mistrik, M., Neelsen, K. J., Yao, Q., Zellweger, R., Kousholt, A. N., Haahr, Peter Thorlund, Chu, W. K., Bartek, J., Lopes, M., Hickson, Ian David & Sørensen, Claus Storgaard, 10 Mar 2015, In: Cell Reports.

    Research output: Contribution to journalJournal articlepeer-review

  68. Published

    Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

    Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

    Xing, M., Wang, X., Palmai-Pallag, T., Shen, H., Helleday, T., Hickson, Ian David & Ying, S., 2015, In: OncoTarget. 6, 35, p. 37638-37646 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

    Newman, J. A., Savitsky, P., Allerston, C. K., Bizard, A. H., Özer, Ö., Sarlós, K., Liu, Ying, Pardon, E., Steyaert, J., Hickson, Ian David & Gileadi, O., 2015, In: Nucleic Acids Research. 43, 10, p. 5221-35 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51

    Chu, W. K., Payne, M. J., Beli, P., Hanada, K., Choudhary, C. & Hickson, Ian David, 2015, In: Nature Communications. 6, 7 p., 5931.

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

    Nielsen, Christian Friberg, Huttner, D., Bizard, A. H., Hirano, S., Li, T., Palmai-Pallag, T., Bjerregaard, V. A., Liu, Ying, Nigg, E. A., Wang, L. H. & Hickson, Ian David, 2015, In: Nature Communications. 6, 15 p., 8962.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Regulation of SUMO2 Target Proteins by the Proteasome in Human Cells Exposed to Replication Stress

    Bursomanno, S., McGouran, J. F., Kessler, B. M., Hickson, Ian David & Liu, Ying, 2015, In: Journal of Proteome Research. 14, 4, p. 1687-99 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. 2014
  75. Published

    Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

    Chatterjee, S., Zagelbaum, J., Savitsky, P., Sturzenegger, A., Huttner, D., Janscak, P., Hickson, Ian David, Gileadi, O. & Rothenberg, E., 24 Nov 2014, In: Nature Communications. 5, p. 1-12 12 p., 5556.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes

    Larsen, N. B., Hickson, Ian David & Mankouri, H. W., 1 Oct 2014, In: Cell Cycle. 13, 19, p. 2994-8 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

    Nguyen, G. H., Tang, W., Robles, A. I., Beyer, R. P., Gray, L. T., Welsh, J. A., Schetter, A. J., Kumamoto, K., Wang, X. W., Hickson, Ian David, Maizels, N., Monnat, R. J. & Harris, C. C., 8 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9905-10 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    The Dissolution of Double Holliday Junctions

    Bizard, A. H. & Hickson, Ian David, 1 Jul 2014, In: Cold Spring Harbor perspectives in biology. 6, p. 1-16 16 p., a016477.

    Research output: Contribution to journalReviewpeer-review

  79. Published

    Structure-specific endonucleases: guardians of fragile site stability

    Minocherhomji, S. & Hickson, Ian David, May 2014, In: Trends in Cell Biology. 24, 5, p. 321-327 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    The origins and processing of ultra fine anaphase DNA bridges

    Liu, Ying, Nielsen, Christian Friberg, Yao, Q. & Hickson, Ian David, 30 Apr 2014, In: Current Opinion in Genetics & Development. 26C, p. 1-5 5 p.

    Research output: Contribution to journalReviewpeer-review

  81. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, M., Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Desler, Claus, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In: DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1

    Bocquet, N., Bizard, A. H., Abdulrahman, W., Larsen, N. B., Faty, M., Cavadini, S., Bunker, R. D., Kowalczykowski, S. C., Cejka, P., Hickson, Ian David & Thomä, N. H., Mar 2014, In: Nature Structural and Molecular Biology. 21, 3, p. 261-8 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast

    Larsen, N. B., Sass, E., Suski, C., Mankouri, H. W. & Hickson, Ian David, 2014, In: Nature Communications. 5, p. 1-10 10 p., 3574.

    Research output: Contribution to journalJournal articlepeer-review

  84. 2013
  85. Published

    FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells

    Simandlova, J., Zagelbaum, J., Payne, M. J., Chu, W. K., Shevelev, I., Hanada, K., Chatterjee, S., Reid, D. A., Liu, Ying, Janscak, P., Rothenberg, E. & Hickson, Ian David, 22 Nov 2013, In: The Journal of Biological Chemistry. 288, 47, p. 34168-80 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining.

    Grabarz, A., Guirouilh-Barbat, J., Barascu, A., Pennarun, G., Genet, D., Rass, E., Germann, S. M., Bertrand, P., Hickson, Ian David & Lopez, B. S., 17 Oct 2013, In: Cell Reports. 5, 1, p. 21-28 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    How unfinished business from S-phase affects mitosis and beyond

    Mankouri, H. W., Huttner, D. & Hickson, Ian David, 16 Oct 2013, In: EMBO Journal. 32, 20, p. 2661-71 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

    Rosenthal, A. S., Dexheimer, T. S., Gileadi, O., Nguyen, G. H., Chu, W. K., Hickson, Ian David, Jadhav, A., Simeonov, A. & Maloney, D. J., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 20, p. 5660-6 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. Published

    PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA

    Biebricher, A., Hirano, S., Enzlin, J., Wiechens, N., Streicher, W., Huttner, D., Wang, L., Nigg, E., Owen-Hughes, T., Liu, Ying, Peterman, E., Wuite, G. & Hickson, Ian David, 12 Sep 2013, In: Molecular Cell. 51, 5, p. 691-701 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  90. Published

    MUS81 promotes common fragile site expression

    Ying, S., Minocherhomji, S., Chan, K. L., Palmai-Pallag, T., Chu, W. K., Wass, T. A., Mankouri, H. W., Liu, Ying & Hickson, Ian David, Aug 2013, In: Nature Cell Biology. 15, 8, p. 1001-1007 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

    Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In: Chemistry & Biology. 20, 1, p. 55-62 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

    Fugger, K., Chu, W. K., Haahr, P., Kousholt, A. N., Beck, H., Payne, M. J., Hanada, K., Hickson, Ian David & Sørensen, Claus Storgaard, 2013, In: Nature Communications. 4, p. 1423

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    RecQ Helicases: Conserved Guardians of Genomic Integrity

    Larsen, N. B. & Hickson, Ian David, 2013, In: Advances in Experimental Medicine and Biology. 767, p. 161-84 24 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. 2012
  95. Published

    BLM and RMI1 Alleviate RPA Inhibition of TopoIIIa Decatenase Activity

    Yang, J., Bachrati, C. Z., Hickson, Ian David & Brown, G. W., Jul 2012, In: P L o S One. 7, 7, p. e41208

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    A novel antirecombinase gains PARIty

    Mankouri, H. W., Chu, W. K. & Hickson, Ian David, Jan 2012, In: Molecular Cell. 45, 1, p. 6-7 2 p.

    Research output: Contribution to journalReviewpeer-review

  97. 2011
  98. Published

    The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination

    Eppink, B., Tafel, A. A., Hanada, K., van Drunen, E., Hickson, Ian David, Essers, J. & Kanaar, R., Nov 2011, In: D N A Repair. 10, 11, p. 1095-105 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    New insights into the formation and resolution of ultra-fine anaphase bridges

    Chan, K. L. & Hickson, Ian David, Oct 2011, In: Seminars in Cell and Developmental Biology. 22, 8, p. 906-12 7 p.

    Research output: Contribution to journalReviewpeer-review

  100. Published

    Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes

    Hickson, Ian David & Mankouri, H. W., Oct 2011, In: Cell Cycle. 10, 18, p. 3078-85 8 p.

    Research output: Contribution to journalReviewpeer-review

  101. Published

    Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae

    Ashton, T. M., Mankouri, H. W., Heidenblut, A., McHugh, P. J. & Hickson, Ian David, 1 May 2011, In: Molecular and Cellular Biology. 31, 9, p. 1921-33 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. Published

    Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis

    Ying, S. & Hickson, Ian David, 1 Apr 2011, In: U H O D. 93, 4, p. 440-5 6 p.

    Research output: Contribution to journalReviewpeer-review

  103. Published

    Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage

    Mankouri, H. W., Ashton, T. M. & Hickson, Ian David, 22 Mar 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 12, p. 4944-9 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Published

    53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

    Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  105. Published

    Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

    Suhasini, A. N., Rawtani, N. A., Wu, Y., Sommers, J. A., Sharma, S., Mosedale, G., North, P. S., Cantor, S. B., Hickson, Ian David & Brosh, R. M., 16 Feb 2011, In: E M B O Journal. 30, 4, p. 692-705 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

    Mohammed, M. Z., Vyjayanti, V. N., Laughton, C. A., Dekker, L. V., Fischer, P. M., Wilson, D. M., Abbotts, R., Shah, S., Patel, P. M., Hickson, Ian David & Madhusudan, S., 15 Feb 2011, In: British Journal of Cancer Management. 104, 4, p. 653-63 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. 2010
  108. Published

    Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3

    Cejka, P., Plank, J. L., Bachrati, C. Z., Hickson, Ian David & Kowalczykowski, S. C., 1 Nov 2010, In: Nature Structural & Molecular Biology. 17, 11, p. 1377-82 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha

    Mönnich, M., Hess, I., Wiest, W., Bachrati, C., Hickson, Ian David, Schorpp, M. & Boehm, T., Sep 2010, In: European Journal of Immunology. 40, 9, p. 2379-84 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  110. Published

    BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells

    Chu, W. K., Hanada, K., Kanaar, R. & Hickson, Ian David, 19 Aug 2010, In: Oncogene. 29, 33, p. 4705-14 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  111. Published

    A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown

    Higgins, G. S., Prevo, R., Lee, Y., Helleday, T., Muschel, R. J., Taylor, S., Yoshimura, M., Hickson, Ian David, Bernhard, E. J. & McKenna, W. G., Apr 2010, In: Cancer Research. 70, 7, p. 2984-93 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  112. Published

    Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1

    Yang, J., Bachrati, C. Z., Ou, J., Hickson, Ian David & Brown, G. W., 2010, In: Journal of Biological Chemistry. 285, 28, p. 21426-36 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  113. Published

    Yeast as a model system to study RecQ helicase function

    Ashton, T. M. & Hickson, Ian David, 2010, In: DNA Repair. 9, 3, p. 303-14 11 p.

    Research output: Contribution to journalReviewpeer-review

  114. 2009
  115. Published

    Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae

    Mankouri, H. W., Ngo, H. & Hickson, Ian David, 1 Mar 2009, In: Molecular Biology of the Cell. 20, 6, p. 1683-94 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  116. Published

    RecQ helicases: multifunctional genome caretakers

    Chu, W. K. & Hickson, Ian David, 2009, In: Nature Reviews. Cancer. 9, p. 644-654 11 p.

    Research output: Contribution to journalReviewpeer-review

  117. 2007
  118. Published

    The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'?

    Mankouri, H. W. & Hickson, Ian David, 1 Dec 2007, In: Trends in Biochemical Sciences. 32, 12, p. 538-46 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  119. Published

    Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3

    Mankouri, H. W., Ngo, H. & Hickson, Ian David, 1 Oct 2007, In: Molecular Biology of the Cell. 18, 10, p. 4062-73 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  120. 2006
  121. Published

    Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage

    Mankouri, H. W. & Hickson, Ian David, 1 Oct 2006, In: Molecular Biology of the Cell. 17, 10, p. 4473-83 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  122. 2005
  123. Published

    A role for the fission yeast Rqh1 helicase in chromosome segregation

    Win, T. Z., Mankouri, H. W., Hickson, Ian David & Wang, S., 15 Dec 2005, In: Journal of Cell Science. 118, Pt 24, p. 5777-84 8 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 17446319