Andres Lopez-Contreras
Affiliate Associate Professor, Affiliated Associate Professor
Molecular Aging Program
Panum Instituttet, Blegdamsvej 3, 2200 København N
Member of:
Web: Center for Healthy Aging
Web Track 1: Modifiable pathways of damage and repair in aging
- 2024
- Published
PICH deficiency limits the progression of MYC-induced B-cell lymphoma
Castejón-Griñán, M., Albers, E., Simón-Carrasco, L., Aguilera, P., Sbroggio, M., Pladevall Morera, David, Ingham, Andreas, Lim, Ernest Wee Kiat, Guillen-Benitez, A., Pietrini, E., Lisby, Michael, Hickson, Ian David & Lopez-Contreras, Andres, 2024, In: Blood Cancer Journal. 14, 1, 15 p., 16.Research output: Contribution to journal › Journal article › peer-review
- 2022
- Published
ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
Pladevall Morera, David, Castejón-Griñán, M., Aguilera, P., Gaardahl, K., Ingham, Andreas, Brosnan-Cashman, J. A., Meeker, A. K. & Lopez-Contreras, Andres, 2022, In: Cancers. 14, 7, 1790.Research output: Contribution to journal › Journal article › peer-review
- 2021
- Published
Genetic insights into biological mechanisms governing human ovarian ageing
Ruth, K. S., Day, F. R., Hussain, J., Martinez-Marchal, A., Aiken, C. E., Azad, A., Thompson, D. J., Knoblochova, L., Abe, H., Tarry-Adkins, J. L., Gonzalez, J. M., Fontanillas, P., Claringbould, A., Bakker, O. B., Sulem, P., Walters, R. G., Terao, C., Turon, S., Horikoshi, M., Lin, K. & 36 others, , 2021, In: Nature. 596, p. 393-397Research output: Contribution to journal › Journal article › peer-review
- 2020
- Published
ATR expands embryonic stem cell fate potential in response to replication stress
Atashpaz, S., Samadi Shams, S., Martin Gonzalez, Javier, Sebestyén, E., Arghavanifard, N., Gnocchi, A., Albers, E., Minardi, S., Faga, G., Soffientini, P., Allievi, E., Cancila, V., Bachi, A., Fernández-Capetillo, Ó., Tripodo, C., Ferrari, F., Lopez-Contreras, Andres & Costanzo, V., 2020, In: eLife. 9, e54756.Research output: Contribution to journal › Journal article › peer-review
- Published
Supraphysiological protection from replication stress does not extend mammalian lifespan
Albers, E., Avram, Alexandra Ioana, Sbroggio, M., Fernandez-Capetillo, O. & Lopez-Contreras, Andres, 2020, In: Aging. 12, 7, p. 5612-5624 13 p.Research output: Contribution to journal › Journal article › peer-review
- 2019
- Published
TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress
Lafarga, V., Sung, H., Haneke, K., Roessig, L., Pauleau, A., Bruer, M., Rodriguez-Acebes, S., Lopez-Contreras, Andres, Gruss, O. J., Erhardt, S., Mendez, J., Fernandez-Capetillo, O. & Stoecklin, G., Jan 2019, In: EMBO Reports. 20, 1, e46224.Research output: Contribution to journal › Journal article › peer-review
- Published
Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability
Pladevall Morera, David, Munk, S., Ingham, Andreas, Garribba, L., Albers, E., Liu, Ying, Olsen, Jesper Velgaard & Lopez-Contreras, Andres, 2019, In: Nucleic Acids Research. 47, 15, p. 8004-8018 15 p.Research output: Contribution to journal › Journal article › peer-review
- 2018
The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase
Lambertos, A., Ramos-Molina, B., Cerezo, D., Lopez-Contreras, Andres & Peñafiel, R., Mar 2018, In: Biochimica et Biophysica Acta - General Subjects. 1862, 3, p. 365-376 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
Albers, E., Sbroggiò, M., Pladevall Morera, David, Bizard, A. H., Avram, Alexandra Ioana, Gonzalez, P., Martin Gonzalez, Javier, Hickson, Ian David & Lopez-Contreras, Andres, 2018, In: Cell Reports. 24, 12, p. 3274-3284 11 p.Research output: Contribution to journal › Journal article › peer-review
New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility
Lambertos, A., Ramos-Molina, B., Lopez-Contreras, Andres, Cremades, A. & Peñafiel, R., 2018, In: PLoS ONE. 13, 12, 22 p., e0209202.Research output: Contribution to journal › Journal article › peer-review
- 2017
- Published
A simple DNA recombination screening method by RT-PCR as an alternative to Southern blot
Albers, E., Sbroggiò, M., Martin Gonzalez, Javier, Avram, Alexandra Ioana, Munk, S. & Lopez-Contreras, Andres, Jun 2017, In: Transgenic Research. 26, 3, p. 429-434 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress
Munk, S., Sigurðsson, J. O., Xiao, Z., Batth, Tanveer Singh, Franciosa, Giulia, von Stechow, L., Lopez-Contreras, Andres, Vertegaal, A. C. O. & Olsen, Jesper Velgaard, 2017, In: Cell Reports. 21, 2, p. 546-558 13 p.Research output: Contribution to journal › Journal article › peer-review
- 2016
- Published
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In: Mechanisms of Ageing and Development. 160, p. 69-92 24 p.Research output: Contribution to journal › Review › peer-review
- Published
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
Herrtwich, L., Nanda, I., Evangelou, K., Nikolova, T., Horn, V., Sagar, Erny, D., Stefanowski, J., Rogell, L., Klein, C., Gharun, K., Follo, M., Seidl, M., Kremer, B., Muenke, N., Senges, J., Fliegauf, M., Aschman, T., Pfeifer, D., Sarrazin, S. & 18 others, , 17 Nov 2016, In: Cell. 167, 5, p. 1264–1280.e18Research output: Contribution to journal › Journal article › peer-review
- Published
Efficacy of ATR inhibitors as single agents in Ewing sarcoma
Nieto-Soler, M., Morgado-Palacin, I., Lafarga, V., Lecona, E., Murga, M., Callen, E., Azorin, D., Alonso, J., Lopez-Contreras, Andres, Nussenzweig, A. & Fernandez-Capetillo, O., 26 Aug 2016, In: OncoTarget. 7, 37, p. 58759-58767Research output: Contribution to journal › Journal article › peer-review
- Published
USP7 is a SUMO deubiquitinase essential for DNA replication
Lecona, E., Rodriguez-Acebes, S., Specks, J., Lopez-Contreras, Andres, Ruppen, I., Murga, M., Muñoz, J., Mendez, J. & Fernandez-Capetillo, O., 23 Apr 2016, In: Nature Structural and Molecular Biology. 23, 4, p. 270-277 8 p.Research output: Contribution to journal › Journal article › peer-review
- 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
Alvarez, S., Díaz, M., Flach, J., Rodriguez-Acebes, S., Lopez-Contreras, Andres, Martínez, D., Cañamero, M., Fernández-Capetillo, O., Isern, J., Passegué, E. & Méndez, J., 12 Oct 2015, In: Nature Communications. 6, p. 8548Research output: Contribution to journal › Journal article › peer-review
- Published
A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development
Specks, J., Lecona, E., Lopez-Contreras, Andres & Fernandez-Capetillo, O., Sep 2015, In: Molecular and Cellular Biology. 35, 17, p. 2910-2917 8 p.Research output: Contribution to journal › Journal article › peer-review
Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells
Ruiz, S., Lopez-Contreras, Andres, Gabut, M., Marion, R. M., Gutierrez-Martinez, P., Bua, S., Ramirez, O., Olalde, I., Rodrigo-Perez, S., Li, H., Marques-Bonet, T., Serrano, M., Blasco, M. A., Batada, N. N. & Fernandez-Capetillo, O., 21 Aug 2015, In: Nature Communications. 6, p. 8036Research output: Contribution to journal › Journal article › peer-review
- Published
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
Lopez-Contreras, Andres, Specks, J., Barlow, J. H., Ambrogio, C., Desler, Claus, Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, Lene Juel, Murga, M., Nussenzweig, A. & Fernandez-Capetillo, O., 1 Apr 2015, In: Genes & Development. 29, 7, p. 690-5 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells
Ramos-Molina, B., Lopez-Contreras, Andres, Lambertos, A., Dardonville, C., Cremades, A. & Peñafiel, R., 2015, In: Amino Acids. 47, 5, p. 1025-34 10 p.Research output: Contribution to journal › Journal article › peer-review
Modeling the study of DNA damage responses in mice
Specks, J., Nieto-Soler, M., Lopez-Contreras, Andres & Fernandez-Capetillo, O., 2015, »Mouse Models of Cancer : Methods and Protocols. Eferl, R. & Casanova, E. (eds.). New York: Springer Science+Business Media, Vol. 1267. p. 413-37 25 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors
Farrés, J., Llacuna, L., Martin-Caballero, J., Martínez, C., Lozano, J. J., Ampurdanés, C., Lopez-Contreras, Andres, Florensa, L., Navarro, J., Ottina, E., Dantzer, F., Schreiber, V., Villunger, A., Fernández-Capetillo, O. & Yélamos, J., 2015, In: Cell Death and Differentiation. 22, p. 1144-157 14 p.Research output: Contribution to journal › Journal article › peer-review
- 2014
A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens
Eguren, M., Álvarez-Fernández, M., García, F., Lopez-Contreras, Andres, Fujimitsu, K., Yaguchi, H., Luque-García, J. L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. & Malumbres, M., 27 Feb 2014, In: Cell Reports. 6, 4, p. 670-83 14 p.Research output: Contribution to journal › Journal article › peer-review
Fos-dependent induction of Chk1 protects osteoblasts from replication stress
Schulze, J., Lopez-Contreras, Andres, Uluçkan, Ö., Graña-Castro, O., Fernandez-Capetillo, O. & Wagner, E. F., 2014, In: Cell Cycle. 13, 12, p. 1980-6 7 p.Research output: Contribution to journal › Journal article › peer-review
Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2
Ramos-Molina, B., Lambertos, A., Lopez-Contreras, Andres, Kasprzak, J. M., Czerwoniec, A., Bujnicki, J. M., Cremades, A. & Peñafiel, R., 2014, In: FEBS Open Bio. 4, p. 510-21 12 p.Research output: Contribution to journal › Journal article › peer-review
- 2013
Mutational analysis of the antizyme-binding element reveals critical residues for the function of ornithine decarboxylase
Ramos-Molina, B., Lambertos, A., Lopez-Contreras, Andres & Peñafiel, R., Nov 2013, In: B B A - Reviews on Cancer. 1830, 11, p. 5157-65 9 p.Research output: Contribution to journal › Journal article › peer-review
The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2
Lopez-Contreras, Andres, de la Morena, M. E., Ramos-Molina, B., Lambertos, A., Cremades, A. & Peñafiel, R., Sep 2013, In: Journal of Cellular Biochemistry. Supplement. 114, 9, p. 1978-86 9 p.Research output: Contribution to journal › Journal article › peer-review
INK4a/ARF limits the expansion of cells suffering from replication stress
Monasor, A., Murga, M., Lopez-Contreras, Andres, Navas, C., Gomez, G., Pisano, D. G. & Fernandez-Capetillo, O., 15 Jun 2013, In: Cell Cycle. 12, 12, p. 1948-54 7 p.Research output: Contribution to journal › Journal article › peer-review
A proteomic characterization of factors enriched at nascent DNA molecules
Lopez-Contreras, Andres, Ruppen, I., Nieto-Soler, M., Murga, M., Rodriguez-Acebes, S., Remeseiro, S., Rodrigo-Perez, S., Rojas, A. M., Mendez, J., Muñoz, J. & Fernandez-Capetillo, O., 25 Apr 2013, In: Cell Reports. 3, 4, p. 1105-16 12 p.Research output: Contribution to journal › Journal article › peer-review
Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression
Marqués-Torrejón, M. Á., Porlan, E., Banito, A., Gómez-Ibarlucea, E., Lopez-Contreras, Andres, Fernández-Capetillo, O., Vidal, A., Gil, J., Torres, J. & Fariñas, I., 3 Jan 2013, In: Cell Stem Cell. 12, 1, p. 88-100 13 p.Research output: Contribution to journal › Journal article › peer-review
Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes
López-Garcia, C., Ramos-Molina, B., Lambertos, A., Lopez-Contreras, Andres, Cremades, A. & Peñafiel, R., 2013, In: PLOS ONE. 8, 7, p. e69188Research output: Contribution to journal › Journal article › peer-review
- 2012
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Bunting, S. F., Callén, E., Kozak, M. L., Kim, J. M., Wong, N., Lopez-Contreras, Andres, Ludwig, T., Baer, R., Faryabi, R. B., Malhowski, A., Chen, H., Fernandez-Capetillo, O., D'Andrea, A. & Nussenzweig, A., 27 Apr 2012, In: Molecular Cell. 46, 2, p. 125-35 11 p.Research output: Contribution to journal › Journal article › peer-review
An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
Lopez-Contreras, Andres, Gutierrez-Martinez, P., Specks, J., Rodrigo-Perez, S. & Fernandez-Capetillo, O., 12 Mar 2012, In: The Journal of Experimental Medicine. 209, 3, p. 455-61 7 p.Research output: Contribution to journal › Journal article › peer-review
Differential expression of ornithine decarboxylase antizyme inhibitors and antizymes in rodent tissues and human cell lines
Ramos-Molina, B., Lopez-Contreras, Andres, Cremades, A. & Peñafiel, R., Feb 2012, In: Amino Acids. 42, 2-3, p. 539-47 9 p.Research output: Contribution to journal › Journal article › peer-review
- 2011
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
Murga, M., Campaner, S., Lopez-Contreras, Andres, Toledo, L. I., Soria, R., Montaña, M. F., D'Artista, L., Schleker, T., Guerra, C., Garcia, E., Barbacid, M., Hidalgo, M., Amati, B. & Fernandez-Capetillo, O., Dec 2011, In: Nature Structural and Molecular Biology. 18, 12, p. 1331-5 5 p.Research output: Contribution to journal › Journal article › peer-review
- 2010
The ATR barrier to replication-born DNA damage
Lopez-Contreras, Andres & Fernandez-Capetillo, O., 10 Dec 2010, In: DNA Repair. 9, 12, p. 1249-55 7 p.Research output: Contribution to journal › Journal article › peer-review
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8
Santos, M. A., Huen, M. S. Y., Jankovic, M., Chen, H., Lopez-Contreras, Andres, Klein, I. A., Wong, N., Barbancho, J. L. R., Fernandez-Capetillo, O., Nussenzweig, M. C., Chen, J. & Nussenzweig, A., 2010, In: The Journal of Experimental Medicine. 207, 5, p. 973-81 9 p.Research output: Contribution to journal › Journal article › peer-review
Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding
Vogler, C., Huber, C., Waldmann, T., Ettig, R., Braun, L., Izzo, A., Daujat, S., Chassignet, I., Lopez-Contreras, Andres, Fernandez-Capetillo, O., Dundr, M., Rippe, K., Längst, G. & Schneider, R., 2010, In: P L o S Genetics. 6, 12, p. e1001234Research output: Contribution to journal › Journal article › peer-review
ID: 122743856
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381
downloads
Interventions for age-related diseases: Shifting the paradigm
Research output: Contribution to journal › Review › peer-review
Published -
239
downloads
Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress
Research output: Contribution to journal › Journal article › peer-review
Published -
209
downloads
Efficacy of ATR inhibitors as single agents in Ewing sarcoma
Research output: Contribution to journal › Journal article › peer-review
Published