DNA repair and mitochondrial homeostasis in the Bohr Group

The primary goals of the Bohr group include the characterization of the biochemical mechanisms that connect DNA damage and mitochondrial dysfunction to normal aging process and in age-related disorders. The group is also conducting intervention studies to increase healthy aging and to delay and reverse age-related diseases especially Alzheimer disease.

DNA repair and mitochondiral homeostasis in the Bohr Group

Research focus

The main focus of the Bohr Group includes the processes of mitochondrial and nuclear DNA damage and repair, mitochondrial biology and energy metabolism, and how these processes interact and are implicated in the aging process and age-associated diseases, especially neurodegenerative disorders. The group is highly motivated to build a bridge between basic and translational research to improve the health of the general elderly population and also to slow down and reverse the pace of disease in individuals who are affected by age-related diseases.

In line with this strategic plan, the group is building a platform for translational research in collaboration with our partners at the University Hospital to use NAD+ supplementation in an intervention study in Alzheimer disease.

Combining a long time scientific research experience and a network of collaborations with internationally recognized researchers we will attempt to successfully implement these plans in the coming years.

Main findings

  • DNA repair deficiency, altered mitochondrial morphology, and impaired process of the elimination of damaged mitochondria by mitophagy, constitute central elements of the aging process and some neurodegenerative disorders.

  • Reduced level of cellular nicotinamide adenine dinucleotide (NAD+) is a key component that links DNA damage to mitochondrial dysfunction.

  • NAD+ supplementation increases lifespan and expands health span in model animals the nematode C. elegans and mice.