Institute of Sports Medicine, Copenhagen – University of Copenhagen

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Projects in Institute of Sports Medicine, Copenhagen

Institute of Sports Medicine (ISMC) is a part of the Department of Orthopedic Surgery at Bispebjerg-Frederiksberg Hospital.

The institute hosts both basic and clinical research within matrix biology and skeletal muscle in relation to elderly individuals. The research focuses on tendon and skeletal muscle and its adaptation to mechanical loading – basic mechanisms and clinical relevance for tissue injury, tendon overloading and age-related muscle loss. It hosts clinicians, basic researchers, integrative and clinical researchers.

Our approach includes: 1) basic molecular and biomechanical investigations, 2) cellular studies on protein expression, 3) synthesis and turnover of collagen and non-collagen matrix proteins , 4) cellular mobility and interaction , 5) physiological studies that determine in vivo measures of tissue turnover and material mechanical properties, 6) long term intervention studies with physical training in elderly individuals that are healthy or have a chronic disease.

Investigation of connective tissue properties have revealed that accumulation of non-reversible advanced glycation end products is reduced in individuals performing life-long endurance sports, and that the connective tissue in tendons becomes loose during inactivity, but acquires its normal characteristics during re-mobilization. Long term training can counteract some of the age-related loss in elasticity of tendon.

The inactivity-related change in mechanical properties can be counteracted by administration of growth hormone and subsequent release of insulin-like growth factor I, particularly in young individuals. We have shown that muscle mass is inversely correlated with level of inflammatory circulating markers. Inactivity-induced muscle loss in the elderly was counteracted somewhat when individuals received anti-inflammatory medication, and in very old patients high levels of inflammatory markers in the circulation inhibited the outcome of strength training.

In 2015 ISMC was part of the Danish group that was announced one of 10 Int Olympic Committee Research Centers around the world. We participate in larger international research efforts (EU), and are part of one of the first 4 announced Clinical Academic Groups under Copenhagen Health Science Partners.

IMSC has 2 Professors, 2 Ass Prof, 4 post docs, 10 phd students and 3 technicians, and houses facilities for human invasive experiments, determination of muscle force/oxygen uptake and cell cultures. Technologies mastered include immunohistochem, fluorescence micr, stable and radioactive tracer studies, protein chemistry, qRT-PCR, atomic force micr, and US mechanical tissue characteristics. The ISMC has intern collab with research groups and exchange of post docs and PhD students.