XLAB – University of Copenhagen

Projects in XLAB

LIFESTAT

More than 600,000 Danes currently take statins as a preventive treatment for cardiovascular disease (CVD). Statins are widely prescribed throughout the developed world to lower blood cholesterol and reduce CVD events and are generally well tolerated.

However, through incompletely understood mechanisms, statins are reported to cause muscle pain (myalgia) in 20-30% of users, and predominantly in people who are physically active. This is counterproductive for health, because it reduces patient compliance in achieving target levels of daily physical activity.

In the present project we aim to determine the biochemical and physiological phenotypes of statin users with and without myalgia. Furthermore we aim to identify and characterize biochemical, physiological, lipidomic and metabolomic markers of statin-induced myalgia.

Ubberup

Today the only successful long term treatment of obesity is surgical and in Denmark the Gastric Bypass operation is favoured. It is well known that intensive lifestyle modification leads to weight loss, but over time the success rate in maintaining weight loss is at best moderate.

Today, there is a number of studies that have investigated the long term effect of weight loss treatments, but there is a lack of studies that focus on factors, that may be decisive for the ability to maintain a changed lifestyle and weight loss after intensive lifestyle modification and there is very limited knowledge about what characterises the few individuals, who are indeed successful in maintaining weight loss.

In this study we aimed to investigate, if there were physiological characteristics that enabled individuals to better maintain lifestyle changes and weight loss in the time after an intensive lifestyle modification.

Resistance Training Intervention

Inactivity independently contributes to the development of cardiovascular disease and type 2 diabetes. Physical activity decreases with increasing age and one of four adults is never physically active. To motivate elderly people to start exercising, new training modalities that increase metabolic health are warranted.

The present project investigates the effect of 6 months of resistance training on insulin sensitivity and secretion in elderly men and women. The aim of the project is to provide evidence, that resistance training can increase metabolic health in the elderly population.

HIT OLD

In the population around 50 % of the older population does not meet the daily physical activity recommendations. Many factors influence this and one is available time. In the latter years high intensity training has proven to be an effective training form and comparable to traditional endurance training. However, it is not clear if this type of training can be performed and tolerated in older individuals and if the training has similar effects as in young people. Therefore, the aim of this study was to do 6 weeks High Intensity training in older and young subjects of both sexes.

DIMITOS

There is some evidence that type 2 diabetes patients does not achieve the same benefits from training when compared to age matched healthy controls. Several mechanism may explain this and one of these is that production of free radicals and control of this process and its effects is attenuated in type 2 diabetes patients. The present study aim to investigate if glutathione supplementation (an antioxidant) in patients with type 2 diabetes and matched controls will enable a better response to acute exercise in type II diabetes patients.

PALERMO

The exercise habits are changing and there are some people that do “Extreme Exercise”, such as triathlons, ultrarunning, repetitive marathons etc. In this study we focus on the effect of 15 days excessive (> 7 hrs per day) repeated exercise in old and young very trained cyclist. The primary aim is to understand the control of energy-balance and the overall capacity to tolerate this excessive amount of exercise, eg. the adaptability of the heart, the muscle, the adipose tissue and low grade inflammation in blood.